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| 1 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 2 | Early detection and identificatiion of dangerous states in chemical plants using neural networks显示文摘 | Joachim Neumann Gorge Deerberg Stefan Schluter | 1999 | J of Loss Prevention in the Process Industries1999，12，6： | 1 |
| 3 | Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome of Elective Coronary Stent Placement显示文摘 | Willibald Hochholzer Dietmar Trenk Hans-Peter Bestehorn Benjamin Fischer Christian M. Valina Miroslaw Ferenc Michael Gick Angelika Caputo Heinz Joachim Büttner Franz-Josef Neumann | 2006 | Journal of the American College of Cardiology2006，，9： | 1 |
| 4 | Ex vivo generation of human anti-melanoma autologous cytolytic T cells by dendritic cell?/melanoma cell hybridomas显示文摘 | Afsaneh Soruri Afshin Fayyazi Christine Neumann Thilo Schlott Thomas Jung Constanze Matthes Joerg Zwirner Joachim Riggert J. Hinrich Peters | 2001 | Cancer Immunology Immunotherapy2001，，6： | 1 |
| 5 | Time Dependence of Platelet Inhibition After a 600-mg Loading Dose of Clopidogrel in a Large, Unselected Cohort of Candidates for Percutaneous Coronary Intervention显示文摘 | Willibald Hochholzer Dietmar Trenk Devine Frundi Philipp Blanke Benjamin Fischer Katharina Andris Hans-Peter Bestehorn Heinz Joachim Büttner Franz-Josef Neumann | 2005 | Circulation2005，，： | 1 |
| 6 | l -Arginine-NO-cGMP signaling following acute liver injury in the rat显示文摘 | Evgeny A. Minin Igor B. Buchwalow Maren Wellner Daniel Palmes Hans-Ullrich Spiegel Joachim Neumann Werner Boecker Hermann Herbst | 2005 | Experimental and Toxicologic Pathology2005，，2： | 1 |
| 7 | 纸与光——Anke Neumann的跨文化研究显示文摘在传统的亚洲文化中,人们认为纸张是一种严肃的建筑材料,广泛地在人们的家中使用。在那里,人们发现纸张拥有诗意的效果。轻盈、柔和、弥漫甚至是稍纵即逝,正是所有的这些特质使纸张变得与众不同。当它与灯光结合的时候,几乎是半透明的。 | Anke Neumann Joachim Ritter Christoph Beer | 2014 | 照明设计2014，0，4： | 0 |
| 8 | 德意志联邦共和国的第一个带掩体的停车洞库显示文摘Wertheim城的地下停车场是德意志联邦共和国的第一个带民防掩体的停车洞库,它就位于与这座中世纪城市中心紧邻的城堡所在的山里。停车容量为300辆。20~30米厚的岩石覆层使得这个民防掩体可以容纳4400人。在斑驳的砂石层里的岩洞由光面爆破形成且用喷浆混凝土和岩锚作为支撑,它的马蹄形横切面分为二个停车层。 | Joachim Neumann 刘洁 | 1989 | 地下空间与工程学报1989，，1： | 0 |
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