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| 1 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 2 | Analysis of roof and pillar failure associated with weak floor at a limestone mine显示文摘A limestone mine in Ohio has had instability problems that have led to massive roof falls extending to the surface. This study focuses on the role that weak, moisture-sensitive floor has in the instability issues.Previous NIOSH research related to this subject did not include analysis for weak floor or weak bands and recommended that when such issues arise they should be investigated further using a more advanced analysis. Therefore, to further investigate the observed instability occurring on a large scale at the Ohio mine, FLAC3 D numerical models were employed to demonstrate the effect that a weak floor has on roof and pillar stability. This case study will provide important information to limestone mine operators regarding the impact of weak floor causing the potential for roof collapse, pillar failure, and subsequent subsidence of the ground surface. | Murphy Michael M. Ellenberger John L. Esterhuizen Gabriel S. Miller Tim | 2016 | International Journal of Mining Science and Technology2016，26，3： | 5 |
| 3 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 4 | Determination of volumetric changes at an underground stone mine: a photogrammetry case study显示文摘Photogrammetry,as a tool for monitoring underground mine deformation,is an alternative to traditional point measurement devices,and may be capable of accurate measurements in situations where technologies such as laser scanning are unsuited,undesired,or cost-prohibitive. An underground limestone mine in Ohio is used as a test case for monitoring of structurally unstable pillars. Seven pillars were photographed over in a 63 day period,punctuated by four visits. Using photogrammetry,point clouds of the mine geometry were obtained and triangulation surfaces were generated to determine volumes of change over time. Pillar spalling in the range of 0.29–4.03 m^3 of rock on individual rib faces was detected.Isolated incidents of rock expansion prior to failure,and the isolated failure of a weak shale band were also observed. Much of the pillars remained unchanged during the monitoring period,which is indicative of proper alignment in the triangulated surfaces. The photographs of some ribs were of either too poor quality or had insufficient overlap,and were not included. However,photogrammetry was successfully applied to multiple ribs in quantifying the pillar geometry change over time. | Slaker Brent Westman Erik Ellenberger John Murphy Michael | 2016 | International Journal of Mining Science and Technology2016，26，1： | 2 |
| 5 | Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells显示文摘 | David M. Booth John A. Murphy Rajarshi Mukherjee Muhammad Awais John P. Neoptolemos Oleg V. Gerasimenko Alexei V. Tepikin Ole H. Petersen Robert Sutton David N. Criddle | 2011 | Gastroenterology2011，，7： | 2 |
| 6 | Role of dissolved organic nitrogen (DON) in soil N cycling in grassland soils显示文摘 | David L. Jones David Shannon Daniel V. Murphy John Farrar | 2004 | Soil Biology and Biochemistry2004，，5： | 2 |
| 7 | Number and Size of Lymph Nodes Recovered From Dukes B Rectal Cancers: Correlation with Prognosis and Histologic Antitumor Immune Response显示文摘 | John Murphy M.B. Marc Pocard M.D. Jeremy R. Jass M.D. F.R.C.Path. Gerald C. O'Sullivan M.Ch. F.R.C.S.I. Garry Lee M.B. F.R.C.Path. Ian C. Talbot M.D. F.R.C.Path | 2007 | Diseases of the Colon & Rectum2007，，10： | 1 |
| 8 | Plasticizers显示文摘 | John Murphy | 1999 | Plastics Additives & Compounding1999，10，2： | 1 |
| 9 | The Toxicology of Perfluorooctanoate显示文摘 | Gerald L. Kennedy John L. Butenhoff Geary W. Olsen John C. O’Connor Andrew M. Seacat Roger G. Perkins Lisa B. Biegel Sandra R. Murphy David G. Farrar | 2004 | Critical Reviews in Toxicology2004，，4： | 1 |
| 10 | Deficiency of ATP-Binding Cassette Transporters A1 and G1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice显示文摘 | Marit Westerterp Andrew J. Murphy Mi Wang Tamara A. Pagler Yuliya Vengrenyuk Mojdeh S. Kappus Darren J. Gorman Prabhakara R. Nagareddy Xuewei Zhu Sandra Abramowicz John S. Parks Carrie Welch Edward A. Fisher Nan Wang Laurent Yvan-Charvet Alan R. Tall | 2013 | Circulation Research2013，，11： | 1 |
| 11 | On-line plate mill process control computer replacement显示文摘 | Murphy T M Johns R L | 1993 | Iron and Steel Engineer1993，70，6： | 1 |
| 12 | On-line plate mill process control computer replacement显示文摘 | Murphy T M Johns R L | 1993 | Iron and Steel Engineer1993，70，6： | 1 |
| 13 | Salicylic acid-induced resistance to viruses and other pathogens: a parting of the ways?显示文摘 | Alex M Murphy Stephen Chivasa Davinder P Singh John P Carr | 1999 | Trends in Plant Science1999，，4： | 1 |
| 14 | Modified cold in-place asphalt recycling 显示文摘 | MURPHY DANIEL T EMERY JOHN J | 1996 | Transportation Research Record1996，，： | 1 |
| 15 | Aging of Precipitated Magnesium Hydroxide 显示文摘 | John w mullin John d Murphy Otakar s | 1989 | Ind Eng Chem Res1989，28，： | 1 |
| 16 | Combinatorial organic synthesis of highly functionized pryrrolidines: idenfication of a potent angiotensin converting enzyme inhibitor from a mercaptoncyl proline library显示文摘 | MARTIN M MURPHY JOHN R SCHULLEK | 1995 | J Am Chem Soc 19951995，，： | 1 |
| 17 | A new reliability growth model: its mathematical comparison to the duane model 显示文摘 | John Donovan Eamonn Murphy | 2000 | Microelectronics reliability2000，40，： | 1 |
| 18 | Direct Activation of Cytosolic Ca 2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells显示文摘 | John A. Murphy David N. Criddle Mark Sherwood Michael Chvanov Rajarshi Mukherjee Euan McLaughlin David Booth Julia V. Gerasimenko Michael G.T. Raraty Paula Ghaneh John P. Neoptolemos Oleg V. Gerasimenko Alexei V. Tepikin Gary M. Green Joseph R. Reeve Ole | 2008 | Gastroenterology2008，，2： | 1 |
| 19 | Risk Factors for Mortality in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy显示文摘 | Douglas A. Jabs Janet T. Holbrook Mark L. Van Natta Rebecca Clark Mark A. Jacobson John H. Kempen Robert L. Murphy | 2005 | Ophthalmology2005，，5： | 1 |
| 20 | Activated systemic inflammatory response at diagnosis reduces lymph node count in colonic carcinoma显示文摘AIM: To investigate a link between lymph node yield and systemic inflammatory response in colon cancer. METHODS: A prospectively maintained database was interrogated. All patients undergoing curative colonic resection were included. Neutrophil lymphocyte ratio(NLR) and albumin were used as markers of SIR. In keeping with previously studies, NLR ≥ 4, albumin < 35 was used as cut off points for SIR. Statistical analysis was performed using 2 sample t-test and χ~2 tests where appropriate.RESULTS: Three hundred and two patients were included for analysis. One hundred and ninety-five patients had NLR < 4 and 107 had NLR ≥ 4. There was no difference in age or sex between groups. Patients with NLR of ≥ 4 had lower mean lymph node yields than patients with NLR < 4 [17.6 ± 7.1 vs 19.2 ± 7.9(P = 0.036)]. More patients with an elevated NLR had node positive disease and an increased lymph node ratio(≥ 0.25, P = 0.044). CONCLUSION: Prognosis in colon cancer is intimately linked to the patient’s immune response. Assuming standardised surgical technique and sub specialty pathology, lymph node count is reduced when systemic inflammatory response is activated. | Rory P Kennelly Brenda Murphy John O Larkin Brian J Mehigan Paul H McCormick | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 1 |
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