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| 1 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Characterization of a small molecule PAI-1 inhibitor, ZK4044显示文摘 | Amy Liang Faye Wu Kathy Tran Steven W. Jones Gary Deng Bin Ye Zhuchun Zhao R. Michael Snider William P. Dole John Morser Qingyu Wu | 2004 | Thrombosis Research2004，，4： | 1 |
| 3 | Energy sorghum biomass harvest thresholds and tillageeffects on soil organic carbon and bulk density显示文摘 | Meki Manyowa N Snider John L Kiniry James R | 2013 | Indus-trial Crops and Products2013，43，： | 1 |
| 4 | Water deficit in field-grown Gossypium hirsutum primarily limits net photosynthesis by decreasing stomatal conductance, increasing photorespiration, and increasing the ratio of dark respiration to gross photosynthesis显示文摘 | Daryl R. Chastain John L. Snider Guy D. Collins Calvin D. Perry Jared Whitaker Seth A. Byrd | 2014 | Journal of Plant Physiology2014，，： | 1 |
| 5 | Physiological and yield responses of field-grown cotton to application of urea with the urease inhibitor NBPT and the nitrification inhibitor DCD显示文摘 | Eduardo M. Kawakami Derrick M. Oosterhuis John L. Snider Morteza Mozaffari | 2012 | European Journal of Agronomy2012，，： | 1 |
| 6 | Applying plant-based irrigation scheduling to assess water use efficiency of cotton following a high-biomass rye cover crop显示文摘Background:This study addressed the potential of combining a high biomass rye winter cover crop with predawn leaf water potential(ΨPD)irrigation thresholds to increase agricultural water use efficiency(WUE)in cotton.To this end,a study was conducted near Tifton,Georgia under a manually-controlled,variable-rate lateral irrigation system using a Scholander pressure chamber approach to measure leaf water potential and impose varying irrigation scheduling treatments during the growing season.ΨPDthresholds were-0.4 MPa(T1),-0.5 MPa(T2),and-0.7 MPa(T3).A winter rye cover crop or conventional tillage were utilized for T1-T3 as well.Results:Reductions in irrigation of up to 10%were noted in this study for the driest threshold(-0.7 MPa)with no reduction in lint yield relative to the-0.4 MPa and-0.5 MPa thresholds.Drier conditions during flowering(2014)limited plant growth and node production,hastened cutout,and decreased yield and WUE relative to 2015.Conclusions:We conclude thatΨPDirrigation thresholds between-0.5 MPa and-0.7 MPa appear to be viable for use in aΨPDscheduling system with adequate yield and WUE for cotton production in the southeastern U.S.Rye cover positively impacted water potential at certain points throughout the growing season but not yield or WUE indicating the potential for rye cover crops to improve water use efficiency should be tested under longer-term production scenarios. | MEEKS Calvin D SNIDER John L CULPEPPER Stanley HAWKINS Gary | 2020 | Journal of Cotton Research2020，3，2： | 0 |
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