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| 1 | Negundoside,an irridiod glycoside from leaves of Vitex negundo,protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride显示文摘AIM:To evaluate the protective effect of 2'-p-hydroxy benzoylmussaenosidic acid [negundoside(NG) ,against carbon tetrachloride(CCl4) -induced toxicity in HuH-7 cells. METHODS:CCl4 is a well characterized hepatotoxin,and inducer of cytochrome P450 2E1(CYP2E1) -mediated oxidative stress. In addition,lipid peroxidation and accumulation of intracellular calcium are important steps in the pathway involved in CCl4 toxicity. Liver cells(HuH-7) were treated with CCl4,and the mechanism of the cytoprotective effect of NG was assessed. Silymarin,a known hepatoprotective drug,was used as control. RESULTS:NG protected HuH-7 cells against CCl4 toxicity and loss of viability without modulating CYP2E1 activity. Prevention of CCl4 toxicity was associated with a reduction in oxidative damage as reflected by decreased generation of reactive oxygen species(ROS) ,a decrease in lipid peroxidation and accumulation of intracellular Ca2+ levels and maintenance of intracellular glutathione homeostasis. Decreased mitochondrial membranepotential(MMP) ,induction of caspases mediated DNA fragmentation and cell cycle arrest,as a result of CCl4 treatment,were also blocked by NG. The protection afforded by NG seemed to be mediated by activation of cyclic adenosine monophosphate(cAMP) synthesis and inhibition of phospholipases(cPLA2) . CONCLUSION:NG exerts a protective effect on CYP2E1-dependent CCl4 toxicity via inhibition of lipid peroxidation,followed by an improved intracellular calcium homeostasis and inhibition of Ca2+-dependent proteases. | Sheikh A Tasduq Peerzada J Kaiser Bishan D Gupta Vijay K Gupta Rakesh K Johri | 2008 | World Journal of Gastroenterology2008，14，23： | 2 |
| 2 | Estimating cell loss rates in high-speed networks with leaky bucket controlled sources显示文摘 | | 1995 | International Journal of Communication Systems1995，8，： | 1 |
| 3 | Effect of graded dietary levels of aflatoxin on total serum proteins,albumin and globulins in broilers显示文摘 | BAKSHI C S SIKDAR A JOHRI T S | 1997 | Indian Journal of Comparative Microbiology Immunology and Infectious Diseases1997，18，2： | 1 |
| 4 | Isolation of sodium chloride-tolerant plantlets of Kickxia ramosissima under in vitro conditions显示文摘 | Mathur A K Ganapathy P S Johri B M | 1980 | Z Pflanzenphysiol1980，99，： | 1 |
| 5 | Occurrence of salt, pH and temperature tolerant, phosphatic solu- bilizing bacteria in alkaline soils显示文摘 | Johri J K Surange S Nautiyal C S | 1999 | Current Microbi- ology1999，39，： | 1 |
| 6 | Induced systemic resistance(ISR) in plants: Mechanism of action 显示文摘 | Choudhary D K Prakash A Johri B N | 2007 | Indian Journal of Microbiology2007，47，8： | 1 |
| 7 | Work values and the quality of employment: A literature review显示文摘 | Johri R | 2004 | New Zealand Department of Labour2004，，14： | 1 |
| 8 | Effect of various levels of aflatoxin and combinations thereof on protein and energy utilization in broilers显示文摘 | Verma J Swain B K Johri T S | | 0，，： | 1 |
| 9 | Real-time three-dimensional transesophageal echocardiography in patients with secundum atrial septal defects:outcomes following transcatheter closure显示文摘 | JOHRI A M WITZKE C SOLIS J | 2011 | J Am Soc Echocardiogr2011，24，： | 1 |
| 10 | Group B Streptococcus: global incidence and vaccine development 显示文摘 | Johri AK Pao|etti LC Glaser P | 2006 | Nat Rev Microbiol2006，4，12： | 1 |
| 11 | Novel thermostable lipase from Bacillus circulans n B153:comparison with the mesostable homologue at sequence and structure level显示文摘 | Johri S Bhat A Sayed S | 2012 | World of Journal Microbiology and Biotechnology2012，28，1： | 1 |
| 12 | Group B Streptococcus : globa incidence and vaccine development显示文摘 | Johri A K Paoletfi L C Glaser P | 2006 | Nature Reviews Microbiology2006，4，12： | 1 |
| 13 | Vesicu- lar-arbuscular mycorrhizae in relation to plant disease 显示文摘 | SHARMA A K JOHRI B N GIANINAZZI S | 1992 | World Journal of Microbiology and Biotechnology1992，8，： | 1 |
| 14 | Effect of vari- ous levels of alfatoxin and ochratoixn A and combina- tions thereof on protein and energy utilization in broil- ers 显示文摘 | VERMA J SWAIN B K JOHRI T S | 2002 | Journal of the Science of Food and Agricul- ture2002，82，： | 1 |
| 15 | Economic burden and cost determinants of deep vein thrombosis during 2 years following diagnosis:a prospective evaluation显示文摘 | Guandla R Ducruet T Johri M et a1 | 2011 | J Thromb Haemost2011，9，12： | 1 |
| 16 | Heavy metal poisoning:the effects of cadmium on the kidney显示文摘 | Johri N Jacquillet G Unwin R | 2010 | Biometals2010，23，5： | 1 |
| 17 | Determination of N-nitrosodimethylamine in enveronmental aqueous samples by isotope-dilution GC/MS-SIM显示文摘 | RAKSIT A JOHRI S J | 2001 | J AOAC Int2001，84，5： | 1 |
| 18 | Effect of supplemental methionine, choline and their combinations on the performance and immune response of broilers显示文摘 | B. K. Swain T. S. Johri | 2000 | British Poultry Science2000，，1： | 1 |
| 19 | Epidemiology ofGroup B Streptococcus in developing countries显示文摘 | Johri AK Lata H Yadav P | 2013 | Vaccine2013，31，4： | 1 |
| 20 | Characterization and regulation of catabolic genes显示文摘 | Johri A K Dua M Singh A | 1999 | Critical Reviews in Microbiology1999，25，4： | 1 |
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