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| 1 | Predisposing factors for positive D-Xylose breath test for evaluation of small intestinal bacterial overgrowth:A retrospective study of 932 patients显示文摘AIM: To investigate, in the largest cohort to date, patient characteristics and associated risk factors for developing small intestinal bacterial overgrowth(SIBO) using the D-Xylose breath test(XBT).METHODS: We performed a retrospective crosssectional study to analyze patient characteristics who underwent the XBT for evaluation of SIBO. Diagnostic testing with the XBT was performed based on a clinical suspicion for SIBO in patients with symptoms of bloating, abdominal pain, abdominal distension, weight loss, diarrhea, and/or constipation. Consecutive electronicmedical records of 932 patients who completed the XBT at the University of Florida between 2005 and 2009 were reviewed. A two-way Analysis of Variance(ANOVA) was used to test for several associations including age, gender, and body mass index(BMI) with a +XBT. A two-way ANOVA was also performed to control for the differences and interaction with age and between genders. A similar analysis was repeated for BMI. Associations between medical conditions and prior surgical histories were conducted using the Mantel-Haenszel method for 2 by 2 contingency tables, stratified for gender. Reported odds ratio estimates reflect the odds of the prevalence of a condition within the +XBT group to that of the-XBT group. P values of less than 0.05(two-sided) were considered statistically significant.RESULTS: In the 932 consecutive eligible subjects studied, 513 had a positive XBT. A positive association was found between female gender and a positive XBT(P = 0.0025), and females with a positive test were, on average, greater than 5 years older than those with a negative test(P = 0.024). The mean BMI of positive XBT subjects was normal(24.5) and significantly lower than the subjects with a negative XBT(29.5)(P = 0.0050). A positive XBT was associated with gastroesophageal reflux disease(GERD)(OR = 1.35; 95%CI: 1.02-1.80, P = 0.04), peptic ulcer disease(PUD)(OR = 2.61; 95%CI: 1.48-4.59, P < 0.01), gastroparesis(GP)(OR = 2.04; 95%CI: 1.21-3.41, P < 0.01) and steroid use(OR = 1.35; 95%CI: 1.02-1.80, P = 0.01). Irritable bowel syndrome, independent protonpump inhibitor(PPI) usage, or previous abdominal surgery was not significantly associated with a positive XBT. No single subdivision by gender or PPI use was associated with a significant difference in the odds ratios between any of the subsets. CONCLUSION: Female gender, lower BMI, steroid use, PUD, GERD(independent of PPI use), and GP were more prevalent in patients with SIBO, determined by a positive XBT. Increasing age was associated with SIBO in females, but not in males. | Richard A Schatz Qing Zhang Nilesh Lodhia Jonathan Shuster Phillip P Toskes Baharak Moshiree | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
| 2 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 3 | Hashash,Nonlinear Ground-Response Analysis of Turkey Flat Shallow Stiff-soil Site to Strong Ground Motion显示文摘 | Annie 0 L Kwok Jonathan P Stewart Youssef M A | 2008 | Bulletin ot' the Seis- mological Society of America February2008，98，： | 1 |
| 4 | AtERF14, a member of the ERF family of transcription factors, plays anonredundant role in plant defense 显示文摘 | Luis onate-Sanchez Jonathan P A Jodi Y | 2007 | Plant Physiology2007，143，1： | 1 |
| 5 | Global consequences of land use显示文摘 | Jonathan A Foley Ruth DeFiles Gregory P Asner | 2005 | Science2005，309，： | 1 |
| 6 | Global consequences oi land use显示文摘 | Jonathan A Foley Ruth DeFries Gregory P Asner etal | 2005 | Science2005，309，5734： | 1 |
| 7 | Sequence architecture within a low-accommodation setting : An example from the Permian of the Galilee and Bowen basins, Queensland, Australia 显示文摘 | Jonathan P A Christopher R F | 2007 | AAPG Bul- letin2007，91，11： | 1 |
| 8 | Iron release from corroded,unlined cast-iron pipe 显示文摘 | Sarin P Jonathan A Clement Vernon L Snoeyink | 2003 | American Water Works Association2003，95，11： | 1 |
| 9 | Global Consequences of Land Use显示文摘 | Jonathan A Foley Ruth Defrles Gregory P Asner | 2005 | Science2005，309，： | 1 |
| 10 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 11 | Plant defense responses: What have we learnt from Arabidopsis?显示文摘 | LOUISE F T Jonathan P A Karam B S | 2005 | Functional Plant Bi- ology2005，32，1： | 1 |
| 12 | Roots of the sec- ond green revolution显示文摘 | LYNCH J P LYNCH A F JONATHAN P | 2007 | Australian Journal of Botany2007，55，5： | 1 |
| 13 | Meta-Analysis of Calcium Supplementation for the Prevention of Postmenopausal Osteoporosis显示文摘 | Beverley S George W Ann C Nicole Z Vivian R Lauren G Zulma O Joan P Jonathan A Peter T Gordon G | 2002 | Endocrine Reviews2002，23，4： | 1 |
| 14 | AtERF14, a member of the ERF family of transcription factors, plays a nonre- dundant role in plant defense显示文摘 | ONATE-SANCHEZ L Jonathan P A Jodi Y | 2007 | Plant Physiology2007，143，1： | 1 |
| 15 | Development of high-rate,adaptive trailing edge control surface for the smart wing phase 2 wind tunnel model显示文摘 | BARTLEY-CHO JONATHAN D WANG DONNY P MARTIN CHRISTOPHER A | 2004 | Journal of Intelligent Material System and Structures2004，15，4： | 1 |
| 16 | Minireview class II transaetivator: mastering the art of major histocompatibility complex expression 显示文摘 | Jonathan A Harton Y Jenny P et ol | 2000 | Mol Cell Biol2000，20，17： | 1 |
| 17 | Mutational analysis of the complement receptor type 2 (CR2/CD21) C3d interaction reveals a putative charged SCR1 binding site for C3d显示文摘 | Jonathan P H Kendra A Y Joel M G | 2005 | J Mol Biol2005，346，： | 1 |
| 18 | Land-use choices: balancing human needs and ecosystem function显示文摘 | Ruth S DeFries Jonathan A Foley Gregory P Asner | 2004 | The Ecological Society of America2004，2，5： | 1 |
| 19 | Global consequences of land use 显示文摘 | Jonathan A F Ruth D Gregory P A | 2005 | Science2005，309，5734： | 1 |
| 20 | Global consequences of land use显示文摘 | JONATHAN A F RUTH D GREGORY P A | 2005 | Science2005，309，5734： | 1 |
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