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| 1 | 有症状的胃食管反流病中埃索美拉唑抑酸能力比奥美拉唑更强显示文摘 | Lind T Rydberg L Kyreback A Jonsson A Andersson T Hasselgren G Holmberg J Rohss K 钟捷 | 2002 | 中华消化杂志2002，22，9： | 6 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Extraction of dansylated amino acids using the supported liquid membrane technique 显示文摘 | WIECZOREKk P JONSSON J A MATHIASSON L | 1997 | Analytica Chimica Acta1997，337，2： | 1 |
| 5 | Electrocoagulation:Experimental intraarterial electrolysis显示文摘 | Samuelsson L Jonsson L Astadius T | 1982 | Acta Radiol Stockh1982，23，： | 1 |
| 6 | Simulation of nitrogen dynamics using the SOITN-model显示文摘 | BERGSTROM L JONSSON H TORSTENSSON G | 1991 | Fret Res1991，15，4： | 1 |
| 7 | Hereditary C2 deficiency in Sweden : frequent occurrence of invasive infection 显示文摘 | Jonsson G Tmedsson L Sturfeh G | 2005 | Medicine ( Baltimore )2005，84，1： | 1 |
| 8 | Circulating anti-elastase in systemic Iupus erytjematosus显示文摘 | Nssberger L Jonsson H Sjohom A G | 1989 | Lancet1989，8636，： | 1 |
| 9 | Improving the fermentability of enzymatic hydrolysates of lignocellulose through chemical in-situ detoxification with reducing agents显示文摘 | Alriksson B Cavka A Jonsson L J | 2011 | Bioresour Technol2011，102，2： | 1 |
| 10 | N-acetylcysteine does not prevent bronchopulmonary dysplasia in immature infants:a randomized controlled trial显示文摘 | Lapatto R Raivio KO Selander B Stigson L Jonsson B | 2003 | J Pediatr2003，143，6： | 1 |
| 11 | TIMESAT-a program for analyzing time-series of satellite sensor data显示文摘 | Jonsson P Eklundh L | 2004 | Computers & Geosciences2004，30，8： | 1 |
| 12 | Cytokinemapping of sera from women with preeclampsia and normalpregnancies显示文摘 | JONSSON Y RUBER M MATTHIESEN L | 2006 | J Reprod Immunol2006，70，： | 1 |
| 13 | Experimentally induced anhydrobiosis in the tardigrade Richtersius coronifer:phenotypic factors affecting survival显示文摘 | Jonsson KI & L Rebecchi | 2002 | J Exp Zool2002，293，： | 1 |
| 14 | Improving the limit of detection of nanoscale sensors by directed binding to high-sensitivity areas显示文摘 | FEUZ L JONSSON P JONSSON M P | 2010 | ACS Nano2010，4，4： | 1 |
| 15 | Viscosities of LF slags and their impact on ladle refining 显示文摘 | Jonsson P G Jonsson L Siehen D | 1997 | ISIJ International1997，37，5： | 1 |
| 16 | lmproved antihypertensive efficiency of the felodipine-metoprolol extended-release tablet compared with each drug alone 显示文摘 | DAHLOF B JONSSON L BORGHOLST O | 1993 | Blood Press1993，2，1： | 1 |
| 17 | Xylem - as well as phloem sustains severe damage clue to feeding by the Russian wheat aphid显示文摘 | Saheed S A Liu L Jonsson L | 2007 | South African Journal of Botany2007，73，4： | 1 |
| 18 | Evaluation of small wastewater treatment systems显示文摘 | Jonsson L | 2003 | Water Science and Technology2003，48，1112： | 1 |
| 19 | Properties and genetic control of four methyltransferases involved in methylation of anthocyanins in flowers of Petunia hybrida显示文摘 | Jonsson L M V Aarsman M E G Poulton J E | 1984 | Planta1984，160，2： | 1 |
| 20 | Influence of tungsten (W) on properties in high nitrogen stainless steels显示文摘 | Jonsson J Y Wegrelius L Heino S | 1999 | Mater Sci Forum1999，，： | 1 |
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