|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergistic effects on cell motility显示文摘MicroRNAs (miRNAs ) ,小非编码的 RNA 的一个重要的班,在 post-transcriptional 水平调整基因表示。miRNAs 涉及大量生物过程并且在不同疾病含有,包括癌症。在这研究, miRNA 介绍和 qRT-PCR 确认揭示了那 miR-142-3p, miR-142-5p 是当疾病进行了,显著地,在 hepatocellular 癌(HCC ) 和他们的表示层次的 downregulated 减少了。miR-142 的宫外的表达式显著地减少了 HCC 房间移植和侵略。miR-142-3p 或 miR-142-5p 的 Overexpression 压制了 HCC 房间移植,并且两个的 overexpression synergistically 禁止了房间移植,它显示 miR-142-3p 和 miR-142-5p 可以合作地调整房间运动。因为他们的不同种子序列, miR-142-3p 和 miR-142-5p,是从先锋 miR-142 的 3' 海滨和 5'-strands 导出的成熟 miRNAs,指向基因的不同水池。小径丰富分析与几个房间显示出 miR-142-3p 和 miR-142-5p 的通常认为的基因目标的一个强壮的协会联系活动性的小径包括那些调整肌动朊细胞骨架, adherens 连接,和焦点的粘附。重要地,很多通常认为的基因目标也是显著地在人的 HCC 房间的 upregulated。而且, miR-142 的 overexpression 显著地在 HCC 房间废除了压力纤维形成并且导致了房间收缩。这研究证明成熟 miR-142 对联合地调整不同发信号的串联的不同部件因此影响 HCC 房间的活动性。 | Felice Ho-Ching Tsang Sandy Leung-Kuen Au Lai Wei Dorothy Ngo-Yin Fan Joyce Man-Fong Lee Carmen Chak-Lui Wong Irene Oi-Lin Ng Chun-Ming Wong | 2015 | Frontiers of Medicine2015，9，3： | 7 |
| 3 | Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis显示文摘 | Peng Gao Carmen Chak-Lui Wong Edmund Kwok-Kwan Tung Joyce Man-Fong Lee Chun-Ming Wong Irene Oi-Lin Ng | 2010 | Journal of Hepatology2010，，6： | 4 |
| 4 | Cost-of-illness studies of diabetes mellitus: A systematic review显示文摘 | Charmaine S. Ng Joyce Y.C. Lee Matthias PHS Toh Yu Ko | 2014 | Diabetes Research and Clinical Practice2014，，： | 1 |
| 5 | The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2显示文摘 | Carmen Chak–Lui Wong Chun–Ming Wong Edmund Kwok–Kwun Tung Sandy Leung–Kuen Au Joyce Man–Fong Lee Ronnie Tung–Ping Poon Kwan Man Irene Oi–Lin Ng | 2011 | Gastroenterology2011，，1： | 1 |
| 6 | C‐terminal truncated hepatitis B virus x protein is associated with metastasis and enhances invasiveness by c‐jun/matrix metalloproteinase protein 10 activation in hepatocellular carcinoma显示文摘 | Karen M.F. Sze Glanice K.Y. Chu Joyce M.F. Lee Irene O.L. Ng | 2013 | Hepatology2013，，1： | 1 |
| 7 | Suppression of cell cycle progression by a fungal lectin:activation of cyclin-dependent kinase inhibitors显示文摘 | Liu Wing-keung Ho Joyce C K Ng Tze-bun | 2001 | Biochemical Pharmacology2001，61，： | 1 |
| 8 | Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles显示文摘 | Joyce Chai Kai-Fai Lee Ernest H.Y. Ng William S.B. Yeung Pak-Chung Ho | 2011 | Fertility and Sterility2011，，： | 1 |
| 9 | Hepatic RIG-I Predicts Survival and Interferon-α Therapeutic Response in Hepatocellular Carcinoma显示文摘 | Jin Hou Ye Zhou Yuanyuan Zheng Jia Fan Weiping Zhou Irene O.L. Ng Huichuan Sun Lunxiu Qin Shuangjian Qiu Joyce M.F. Lee Chung-Mau Lo Kwan Man Yuan Yang Yun Yang Yingyun Yang Qian Zhang Xuhui Zhu Nan Li Zhengxin Wang Guoshan Ding Shi-Mei Zhuang Limin Zheng | 2013 | Cancer Cell2013，，： | 1 |
| 10 | High frequency of chimerism in transplanted livers显示文摘 | Irene Oi-Lin Ng Kok-Lung Chan Wai-Hung Shek Joyce Man-Fong Lee Daniel Yee-Tak Fong Chung-Mau Lo Sheung-Tat Fan | 2003 | Hepatology2003，，4： | 1 |
| 11 | Metabolic and Adipokine Profile of Chinese Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Vincent Wai–Sun Wong Alex Yui Hui Steven Woon–Choy Tsang Joyce Lai–Yee Chan Ada Mei–Ling Tse Kui–Fat Chan Wing–Yee So Angela Yuen–Shan Cheng Wing–Fung Ng Grace Lai–Hung Wong Joseph Jao–Yiu Sung Henry Lik–Yuen Chan | 2006 | Clinical Gastroenterology and Hepatology2006，，9： | 1 |
| 12 | Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques,hyperphosphorylated tau protein,and neurofibrillary tangles in the brain.The overexpression of amyloid-βprecursor protein(APP)in an AD brain results in the binding of APP intracellular domain(AICD)to Fe65 protein via the C-terminal Fe65-PTB2 interaction,which then triggers the secretion of amyloid-βand the consequent pathogenesis of AD.Apparently,targeting the interaction between APP and Fe65 can offer a promising therapeutic approach for AD.Recently,exosome,a type of extracellular vesicle with diameter around 30–200 nm,has gained much attention as a potential delivery tool for brain diseases,including AD,due to their ability to cross the blood–brain barrier,their efficient uptake by autologous cells,and their ability to be surface-modified with target-specific receptor ligands.Here,the engineering of hippocampus neuron cell-derived exosomes to overexpress Fe65,enabled the development of a novel exosome-based targeted drug delivery system,which carried Corynoxine-B(Cory-B,an autophagy inducer)to the APP overexpressed-neuron cells in the brain of AD mice.The Fe65-engineered HT22 hippocampus neuron cell-derived exosomes(Fe65-EXO)loaded with Cory-B(Fe65-EXO-Cory-B)hijacked the signaling and blocked the natural interaction between Fe65 and APP,enabling APP-targeted delivery of Cory-B.Notably,Fe65-EXO-Cory-B induced autophagy in APP-expressing neuronal cells,leading to amelioration of the cognitive decline and pathogenesis in AD mice,demonstrating the potential of Fe65-EXO-Cory-B as an effective therapeutic intervention for AD. | Ashok Iyaswamy Abhimanyu Thakur Xin-Jie Guan Senthilkumar Krishnamoorthi Tsz Yan Fung Kejia Lu Isha Gaurav Zhijun Yang Cheng-Fu Su Kwok-Fai Lau Kui Zhang Roy Chun-Laam Ng Qizhou Lian King-Ho Cheung Keqiang Ye Huanhuan Joyce Chen Min Li | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 13 | 新加坡UOL Edge画廊显示文摘近年来,新加坡正在经历一场住宅公寓开发的热潮。因此,建筑师一直呼吁设计一个临时性的展示建筑,用来展示这些建筑,并促进其出售。很多展示空间的设计显然并不能引发丰富的想象,反而呈现出一种程式化的相似——与建筑表皮完全无关的笨拙、匀称的立方体玻璃、石膏、木材与室内设计的表现形式,典型的毫无节制的奢华和一成不变的排场。顺应这一潮流,MOD设计的这座画廊探讨并重新定义了象征新加坡公共管理能力的展示空间的类型。 | Colin Seah Tulsi Grover Joyce Low Angie Ng Anita Shewchuk Ron Sim David Tan Marcin Skolimowski Noel Banta Aliza Suarez Lolleth Alejandro Allan Veloso Pauline Pan | 2012 | 设计家2012，，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员