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| 1 | Effect of in-hospital medical complications on case fatality post-acute ischemic stroke: data from the China National Stroke Registry显示文摘 | WANG Peng-lian ZHAO Xing-quan YANG Zhong-hua WANG An-xin WANG Chun-xue LIU Li-ping WANGYi-long WANG Xin-gao JU Yi CHEN Sheng-yun CHEN Qi-dong QU Hui LU Jing-jing ZHANG Jing MA Rui-hua ZHANG Yu-mei WANG Yong-jun | 2012 | Chinese Medical Journal2012，，14： | 37 |
| 2 | Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases显示文摘背景有针的绳索殴打的脊柱受伤的发生在发达国家高并且现在在中国正在成长。而且,针的绳索损害主要在有长寿期待的年轻人发生。很多病人因此是为他们的生活的其余部分的轮椅界限。因此,针的绳索损害引起了世界范围的大担心。尽管有大努力,从针的绳索损害的恢复仍然保持不能令人满意。基于针的绳索殴打的病理,早 neurosurgical 干预的一个想法在这研究被提出了。有“完全”的针的绳索损害的 30 个病人全部或象美国脊柱受伤协会(亚洲) A 分类的方法 A 被学习。受伤椎骨(e) ,脊椎的列的内部固定,和为硬膜上的解压缩的双边的 laminectomy 的矫形治疗被 neurosurgical 管理直接跟随,包括恢复脑髓的液体流动和针的绳索的清创术的蛛网状的粘附的分离有伴随物 intramedullary 解压缩的坏死的织物。康复在操作以后开始了 17 天。最后的结果在 3 月康复以后被评估。皮尔森 chi 平方分析被用于统计分析。所有病人恢复了的结果走的某能力。最少的恢复病人能在稳定忍受膝关节的重量与 wheeled 重量支持和帮助走(12 个盒子, 40%) 。13 个病人(43%) 能与一双丁字拐走,一根棍子或没有任何支持。在损害以后预定操作是重要的。一扇最佳的操作时间窗户在损害以后在 4-14 天被识别。康复跟随的针的绳索殴打的结论早 neurosurgical 干预能显著地改进病人的运动。它是为针的绳索殴打的一条治疗学的途径的一个新想法并且被证明了很成功。 | ZHU Hui FENG Ya-ping Young Wise YOU Si-wei SHEN Xue-feng LIU Yan-sheng JU Gong | 2008 | Chinese Medical Journal2008，，24： | 30 |
| 3 | Arpin contributes to bacterial translocation and development of severe acute pancreatitis显示文摘AIM: To assess the impact of Arpin protein and tight junction(TJ) proteins in the intestinal mucosa onbacterial translocation in patients with severe acute pancreatitis(SAP).METHODS: Fifty SAP patients were identified as study objects and then classified into two groups according to the presence of bacterial translocation(BT) in the blood [i.e., BT(+) and BT(-)].Twenty healthy individuals were included in the control group.BT was analyzed by polymerase chain reaction, colonic mucosal tissue was obtained by endoscopy and the expression of TJ proteins and Arpin protein was determined using immunofluorescence and western blotting.RESULTS: Bacterial DNA was detected in the peripheral blood of 62.0% of patients(31/50) with SAP.The expression of TJ proteins in SAP patients was lower than that in healthy controls.In contrast, Arpin protein expression in SAP patients was higher than in healthy controls(0.38 ± 0.19 vs 0.28 ± 0.16, P < 0.05).Among SAP patients, those positive for BT showed a higher level of claudin-2 expression(0.64 ± 0.27 vs 0.32 ± 0.21, P < 0.05) and a lower level of occludin(OC)(0.61 ± 0.28 vs 0.73 ± 0.32, P < 0.05) and zonula occludens-1(0.42 ± 0.26 vs 0.58 ± 0.17, P = 0.038) expression in comparison with BT(-) patients.Moreover, the level of Arpin expression in BT(+) patients was higher than in BT(-) patients(0.61 ± 0.28 vs 0.31 ± 0.24, P < 0.05).CONCLUSION: Arpin protein affects the expression of tight junction proteins and may have an impact on BT.These results contribute to a better understanding of the factors involved in bacterial translocation during acute pancreatitis. | Wen-Sheng Deng Jian Zhang Hui Ju Hong-Mei Zheng Jiang Wang Su Wang Dian-Liang Zhang | 2015 | World Journal of Gastroenterology2015，21，14： | 20 |
| 4 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 5 | Molecular Characterization of Drug-Resistant Beijing Family Isolates of Mycobacterium Tuberculosis from Tianjin,China显示文摘Objective Tuberculosis remains a severe public health issue,and the Beijing family of mycobacterium tuberculosis(M. tuberculosis) is widespread in East Asia,especially in some areas in China,like Beijing and Tianjin.This study aimed at determining the mutation patterns of drug-resistant Beijing strains of M.tuberculosis isolated from Tianjin,China.Methods A total of 822 M.tuberculosis isolates were screened for drug resistance by an absolute concentration method and the genotype was identified by PCR.169 drug-resistant isolates of the Beijing family were analyzed for the potential mutations in the rpoB, katG,inhA promoter region and in rpsL,rrs and embB genes,which are associated with resistance to rifampin(RFP),isoniazid (INH),streptomycin(SM) and ethambutol(EMB) respectively by PCR and DNA sequencing.Results Fifty-eight out of 63 RFP-resistant isolates were found to carry the mutations within the 81-bp RFP resistance determining region(RRDR) of the rpoB gene and the most frequent mutations occurred at codon 531(44.4%),526(28.6%),and 516(7.9%) respectively.16 mutation patterns affecting 12 different codons around the RRDR of rpoB were found.Of 116 INH-resistant isolates,56(48.3%) had the mutation of katG 315(AGC→ACC)(Ser→Thr),3(2.6%) carried S315N(AGC→AAC) and 27(16.0%) had the mutation of inhA-15A→T.84 out of 122 SM-resistant isolates(68.9%) displayed mutations at the codons 43 or 88 with AAG→AGG(Lys→Arg) of the rpsL gene and 22(18.0%) with the mutations at positions 513A→C,516C→T or 905 A→G in the rrs gene.Of 34 EMB-resistant isolates,6 had mutation with M306V(ATG→GTG),3 with M306I(ATG→ATT),1 with M306I(ATG→ATA),1 with D328Y(GAT→TAT),1 with V348L(GTC→CTC),and 1 with G406S(GGC→AGC) in the embB gene.Conclusion These novel findings extended our understanding of resistance-related mutations in the Beijing strains of M.tuberculosis and may provide a scientific basis for development of new strategies for diagnosis and control of tuberculosis in China and other countries where Beijing strains are prevalent. | GUI-LIAN LI DE-FU ZHAO TONG XIE HAN-FANG JU CHENG MU HUI ZHAO XIE-XIU WANG | 2010 | Biomedical and Environmental Sciences2010，23，3： | 14 |
| 6 | Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy显示文摘Objective To explore the relationship between HBV DNA and the clinical manifestations, pathological types, injury severity, and prognosis with HBV-GN. Methods 102 patients with HBV-GN were divided into 3 groups, according to the serum titer of the HBV DNA. 24-h urine protein excretion, and other parameters were measured. Renal biopsy were performed. The association between HBV DNA and the pathological stage of membranous nephropathy was analyzed in 78 patients with HBV-MN. 24-h urine protein excretion was used for the evaluation of the prognosis, and the relationship between HBV DNA and prognosis were analyzed. Results Several findings were demonstrated with the increase of serum HBV DNA: 24-h urine protein excretion, plasma cholesterol, and triglycerides increased significantly(P<0.05), while the plasma level of albumin decreased significantly(P<0.05); The changes of serum creatinine, C3 and C4 were found but no statistical significance. Glomerular deposition of HBVAg increased, and the pathological injury was more severe. The clinical remission rate was lower in the high replication group after treatment as compared with the low replication group(P<0.01). Conclusion With the increase of serum HBV DNA, the urine protein excretion and the kidney injury were more severe, and the clinical remission rate was decreased. | JIANG Wei LIU Tuo DONG Hui XU Yan LIU Li Qiu GUAN Guang Ju LIU Xiang Chun | 2015 | Biomedical and Environmental Sciences2015，28，3： | 13 |
| 7 | Water consumption in summer maize and winter wheat cropping system based on SEBAL model in Huang-Huai-Hai Plain, China显示文摘Crop consumptive water use is recognized as a key element to understand regional water management performance. This study documents an attempt to apply a regional evapotranspiration model(SEBAL) and crop information for assessment of regional crop(summer maize and winter wheat) actual evapotranspiration(ET a) in Huang-Huai-Hai(3H) Plain, China. The average seasonal ET a of summer maize and winter wheat were 354.8 and 521.5 mm respectively in 3H Plain. A high-ET a belt of summer maize occurs in piedmont plain, while a low ET a area was found in the hill-irrigable land and dry land area. For winter wheat, a high-ET a area was located in the middle part of 3H Plain, including low plain-hydropenia irrigable land and dry land, hill-irrigable land and dry land, and basin-irrigable land and dry land. Spatial analysis demonstrated a linear relationship between crop ET a, normalized difference vegetation index(NDVI), and the land surface temperature(LST). A stronger relationship between ET a and NDVI was found in the metaphase and last phase than other crop growing phase, as indicated by higher correlation coefficient values. Additionally, higher correlation coefficients were detected between ET a and LST than that between ET a and NDVI, and this significant relationship ran through the entire crop growing season. ET a in the summer maize growing season showed a significant relationship with longitude, while ET a in the winter wheat growing season showed a significant relationship with latitude. The results of this study will serve as baseline information for water resources management of 3H Plain. | YANG Jian-ying MEI Xu-rong HUO Zhi-guo YAN Chang-rong JU Hui ZHAO Feng-hua LIU Qin | 2015 | Journal of Integrative Agriculture2015，14，10： | 12 |
| 8 | Fluid-structure Interaction Analysis and Lifetime Estimation of a Natural Gas Pipeline Centrifugal Compressor under Near-choke and Near-surge Conditions显示文摘Up to present, there have been no studies concerning the application of fluid-structure interaction(FSI) analysis to the lifetime estimation of multi-stage centrifugal compressors under dangerous unsteady aerodynamic excitations. In this paper, computational fluid dynamics(CFD) simulations of a three-stage natural gas pipeline centrifugal compressor are performed under near-choke and near-surge conditions, and the unsteady aerodynamic pressure acting on impeller blades are obtained. Then computational structural dynamics(CSD) analysis is conducted through a one-way coupling FSI model to predict alternating stresses in impeller blades. Finally, the compressor lifetime is estimated using the nominal stress approach. The FSI results show that the impellers of latter stages suffer larger fluctuation stresses but smaller mean stresses than those at preceding stages under near-choke and near-surge conditions. The most dangerous position in the compressor is found to be located near the leading edge of the last-stage impeller blade. Compressor lifetime estimation shows that the investigated compressor can run up to 102.7 h under the near-choke condition and 200.2 h under the near-surge condition. This study is expected to provide a scientific guidance for the operation safety of natural gas pipeline centrifugal compressors. | JU Yaping LIU Hui YAO Ziyun XING Peng ZHANG Chuhua | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 11 |
| 9 | Spatiotemporal Characteristics of Reference Evapotranspiration and Its Sensitivity Coefficients to Climate Factors in Huang-Huai-Hai Plain,China显示文摘Climate change will have important implications in water shore regions,such as Huang-Huai-Hai(3H)plain,where expected warmer and drier conditions might augment crop water demand.Sensitivity analysis is important in understanding the relative importance of climatic variables to the variation in reference evapotranspiration(ET0).In this study,the 51-yr ET0during winter wheat and summer maize growing season were calculated from a data set of daily climate variables in 40meteorological stations.Sensitivity maps for key climate variables were estimated according to Kriging method and the spatial pattern of sensitivity coefficients for these key variables was plotted.In addition,the slopes of the linear regression lines for sensitivity coefficients were obtained.Results showed that ET0during winter wheat growing season accounted for the largest proportion of annual ET0,due to its long phenological days,while ET0was detected to decrease significantly with the magnitude of 0.5 mm yr-1in summer maize growing season.Solar radiation is considered to be the most sensitive and primarily controlling variable for negative trend in ET0for summer maize season,and higher sensitive coefficient value of ET0to solar radiation and temperature were detected in east part and southwest part of 3H plain respectively.Relative humidity was demonstrated as the most sensitive factor for ET0in winter wheat growing season and declining relativity humidity also primarily controlled a negative trend in ET0,furthermore the sensitivity coefficient to relative humidity increased from west to southeast.The eight sensitivity centrals were all found located in Shandong Province.These ET0along with its sensitivity maps under winter wheat-summer maize rotation system can be applied to predict the agricultural water demand and will assist water resources planning and management for this region. | YANG Jian-ying LIU Qin MEI Xu-rong YAN Chang-rong JU Hui XU Jian-wen | 2013 | Journal of Integrative Agriculture2013，12，12： | 11 |
| 10 | Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response显示文摘Hypoxic-ischemic brain damage(HIBD)is a common cause of infant death.The purpose of our research was to explore the immunoregulatory mechanism of placenta-derived mesenchymal stem cells(PD-MSCs)in HIBD treatment.Seven-day-old rat pups were randomly divided into HIBD,PD-MSC,fibroblast,and control groups.Forty-eight hours after HIBD induction,cells at a density of 5×104 cells/10µl were injected into the cerebral tissue in the PD-MSC and fibroblast groups.The TNF-α,interleukin-17(IL-17),interferon-γ(IFN-γ),and IL-10 levels were detected through quantitative real-time polymerase chain reaction(RT-PCR)and enzyme-linked immunosorbent assay(ELISA).Regulatory T cell(Tregs)populations were detected through flow cytometry,and forkhead box P3(Foxp3)was measured through western blot analysis.Behavioral tests and gross and pathological examinations showed that PD-MSC treatment exerted significantly stronger neuroprotective effects than the other treatments.The expression levels of pro-inflammatory cytokines were substantially upregulated after HI injury.Compared with fibroblast treatment,PD-MSC treatment inhibited the production of pro-inflammatory cytokines and increased the production of IL-10 in the ischemic hemispheres and peripheral blood serum(all P<0.01).Flow cytometry results showed a notable increase in the number of Tregs within the spleen of the HIBD group.Moreover,the number of Tregs and the Foxp3 expression levels were higher in the PD-MSC treatment group than in the HIBD and fibroblast groups(all P<0.01).Our research suggests that the mechanism of PD-MSC treatment for HIBD partially involves inflammatory response suppression. | Hongfang Ding Hui Zhang Huifang Ding Dong Li Xinhao Yi Xiaoxu Ma Ruijuan Li Mei Huang Xiuli Ju | 2017 | Cellular & Molecular Immunology2017，14，8： | 10 |
| 11 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 12 | A Survey on Emerging Computing Paradigms for Big Data显示文摘The explosive growth of data volume and the ever-increasing demands of data value extraction have driven us into the era of big data. The '5V'(Variety,Velocity, Volume, Value, and Veracity) characteristics of big data pose great challenges to traditional computing paradigms and motivate the emergence of new solutions.Cloud computing is one of the representative technologies that can perform massive-scale and complex data computing by taking advantages of virtualized resources, parallel processing and data service integration with scalable data storage. However, as we are also experiencing the revolution of Internet-of-things(IoT), the limitations of cloud computing on supporting lightweight end devices significantly impede the flourish of cloud computing at the intersection of big data and IoT era. It also promotes the urgency of proposing new computing paradigms. We provide an overview on the topic of big data, and a comprehensive survey on how cloud computing as well as its related technologies can address the challenges arisen by big data.Then, we analyze the disadvantages of cloud computing when big data encounters IoT, and introduce two promising computing paradigms, including fog computing and transparent computing, to support the big data services of IoT. Finally, some open challenges and future directions are summarized to foster continued research efforts into this evolving field of study. | ZHANG Yaoxue REN Ju LIU Jiagang XU Chugui GUO Hui LIU Yaping | 2017 | Chinese Journal of Electronics2017，26，1： | 8 |
| 13 | The impacts of climate change on wheat yield in the Huang-Huai-Hai Plain of China using DSSAT-CERES-Wheat model under different climate scenarios显示文摘Climate change has been documented as a major threat to current agricultural strategies.Progress in understanding the impact of climate change on crop yield is essential for agricultural climate adaptation,especially for the Huang-Huai-Hai Plain(3H Plain)of China which is an area known to be vulnerable to global warming.In this study,the impacts of climate change on winter wheat(Triticum aestivum L.)yield between the baseline period(1981–2010)and two Representative Concentration Pathways(RCP8.5 and RCP4.5)were simulated for the short-term(2010–2039),the medium-term(2040–2069)and the long-term(2070–2099)in the 3H Plain,by considering the relative contributions of changes in temperature,solar radiation and precipitation using the DSSAT-CERES-Wheat model.Results indicated that the maximum and minimum temperatures(TMAX and TMIN),solar radiation(SRAD),and precipitation(PREP)during the winter wheat season increased under these two RCPs.Yield analysis found that wheat yield increased with the increase in SRAD,PREP and CO2 concentration,but decreased with an increase in temperature.Increasing precipitation contributes the most to the total impact,increasing wheat yield by 9.53,6.62 and 23.73%for the three terms of future climate under RCP4.5 scenario,and 11.74,16.38 and 27.78%for the three terms of future climate under RCP8.5 scenario.However,as increases in temperature bring higher evapotranspiration,which further aggravated water deficits,the supposed negative effect of increasing thermal resources decreased wheat yield by 1.92,4.08 and 5.24%for the three terms of future climate under RCP4.5 scenario,and 3.64,5.87 and 5.81%for the three terms of future climate under RCP8.5 scenario with clearly larger decreases in RCP8.5.Counterintuitively,the impacts in southern sub-regions were positive,but they were all negative in the remaining sub-regions.Our analysis demonstrated that in the 3H Plain,which is a part of the mid-high latitude region,the effects of increasing thermal resources were counteracted by the aggravated water deficits caused by the increase in temperature. | QU Chun-hong LI Xiang-xiang JU Hui LIU Qin | 2019 | Journal of Integrative Agriculture2019，18，6： | 7 |
| 14 | Loss of micro RNA-124 expression in neurons in the peri-lesion area in mice with spinal cord injury显示文摘Micro RNA-124(mi R-124) is abundantly expressed in neurons in the mammalian central nervous system, and plays critical roles in the regulation of gene expression during embryonic neurogenesis and postnatal neural differentiation. However, the expression profile of mi R-124 after spinal cord injury and the underlying regulatory mechanisms are not well understood. In the present study, we examined the expression of mi R-124 in mouse brain and spinal cord after spinal cord injury using in situ hybridization. Furthermore, the expression of mi R-124 was examined with quantitative RT-PCR at 1, 3 and 7 days after spinal cord injury. The mi R-124 expression in neurons at the site of injury was evaluated by in situ hybridization combined with Neu N immunohistochemical staining. The mi R-124 was mainly expressed in neurons throughout the brain and spinal cord. The expression of mi R-124 in neurons significantly decreased within 7 days after spinal cord injury. Some of the neurons in the peri-lesion area were Neu N+/mi R-124-. Moreover, the neurons distal to the peri-lesion site were Neu N+/mi R-124+. These findings indicate that mi R-124 expression in neurons is reduced after spinal cord injury, and may reflect the severity of spinal cord injury. | Yu Zhao Hui Zhang Dan Zhang Cai-yong Yu Xiang-hui Zhao Fang-fang Liu Gan-lan Bian Gong Ju Jian Wang | 2015 | Neural Regeneration Research2015，10，7： | 7 |
| 15 | Geochronology and Geochemistry of Metallogenetic Porphyry Bodies from the Nongping Au-Cu Deposit in the Eastern Yanbian Area, NE China: Implications for Metallogenic Environment显示文摘The metallogenetic porphyry bodies in the Nongping Au-Cu deposit, in the eastern Yanbian area, mainly include porphyritic granodiorite and biotite granodiorite porphyry. They are featured with high silicon and enrichment in sodium, and classified into sodic rocks of low-K tholeiitic basalt series. Except slightly low Sr content, the rock basically has the geochemical characteristics of the adakite: relatively high A12O3 content, relatively low MgO content, depletion in Y and Yb; relative enrichment in large ion lithophile elements (LILEs) and light rare-earth elements (LREEs), relatively low content of high field strength elements (HFSEs); positive Eu anomaly or weak negative Eu anomaly. In situ zircon dating technology LA-MC-ICP-MS was used to conduct single-grain zircon dating of biotite granodiorite porphyry, and the results show that the age of metallogenetic porphyry body is 100.04±0.88 Ma, indicating that the porphyry bodies were emplaced in the late Cretaceous period. According to the regional tectonic setting and the comparison with the same kind of deposits, we think that the metallogenetic porphyry bodies in the Nongping Au-Cu deposit have a close genetic connection with the subduction of the Pacific plate in the late Yanshanian period. The adakitic magma generated from partial melting of the subducting plate has high formation temperature, high oxygen fugacity, and volatile constituents' enrichment, so it is helpful for enrichment of metallogenetic elements and plays an important role in the formation of porphyry Au-Cu deposits in this region. | REN Yunsheng JU Nan ZHAO Hualei WANG Hui HOU Kejun LIU Shen | 2012 | Acta Geologica Sinica(English Edition)2012，86，3： | 7 |
| 16 | Spatiotemporal variation of drought characteristics in the Huang- Huai-Hai Plain, China under the climate change scenario显示文摘Understanding the potential drought characteristics under climate change is essential to reduce vulnerability and establish adaptation strategies,especially in the Huang-Huai-Hai Plain(3 H Plain),which is a major grain production area in China. In this paper,we investigated the variations in drought characteristics(drought event frequency,duration,severity,and intensity) for the past 50 years(1961–2010) and under future scenarios(2010–2099),based on the observed meteorological data and the Representative Concentration Pathway(RCP) 8.5 scenario,respectively. First,we compared the applicability of three climatic drought indices:the standardized precipitation index(SPI),the standardized precipitation evapotranspiration index based on the Penman-Monteith equation(SPEI-PM) and the same index based on the Thornthwaite equation(SPEI-TH) to correlate the recorded agricultural drought areas. Then,we analyzed the drought characteristics using ‘run theory' for both historical and the future RCP 8.5 scenario based on the best performing index. Correlation analyses between drought indices and agricultural drought areas showed that SPEI-PM performed better than SPI and SPEI-TH in the 3 H Plain. Based on the results of SPEI-PM,drought risks including duration,severity and intensity during 1961–2010 showed an decreasing trend. However,under the RCP 8.5 scenario,drought is expected to rise in frequency,duration,severity,and intensity from 2010–2099,although drought components during the 2010–2039 are predicted to be milder compared with historical conditions. This study highlights that the estimations for atmospheric evaporative demand would create differences in the prediction of long-term drought trends by different drought indices. The results of this study can help inform researchers and local policy makers to establish drought management strategies. | LI Xiang-xiang JU Hui Sarah Garré YAN Chang-rong William D.Batchelor LIU Qin | 2017 | Journal of Integrative Agriculture2017，16，10： | 6 |
| 17 | Alpha-fetoprotein-targeted reporter gene expression imaging in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is one of the most common cancers in Eastern Asia, and its incidence is increasing globally. Numerous experimental models have been developed to better our understanding of the pathogenic mechanism of HCC and to evaluate novel therapeutic approaches. Molecular imaging is a convenient and up-to-date biomedical tool that enables the visualization, characterization and quantification of biologic processes in a living subject. Molecular imaging based on reporter gene expression, in particular, can elucidate tumor-specific events or processes by acquiring images of a reporter gene's expression driven by tumor-specific enhancers/promoters. In this review, we discuss the advantages and disadvantages of various experimental HCC mouse models and we present in vivo images of tumorspecific reporter gene expression driven by an alphafetoprotein(AFP) enhancer/promoter system in a mouse model of HCC. The current mouse models of HCC development are established by xenograft, carcinogen induction and genetic engineering, representing the spectrum of tumor-inducing factors and tumor locations. The imaging analysis approach of reporter genes driven by AFP enhancer/promoter is presented for these different HCC mouse models. Such molecular imaging can provide longitudinal information about carcinogenesis and tumor progression. We expect that clinical application of AFP-targeted reporter gene expression imaging systems will be useful for the detection of AFP-expressing HCC tumors and screening of increased/decreased AFP levels due to disease or drug treatment. | Kwang Il Kim Hye Kyung Chung Ju Hui Park Yong Jin Lee Joo Hyun Kang | 2016 | World Journal of Gastroenterology2016，22，27： | 6 |
| 18 | Synthesis and biological evaluation of novel triazole derivatives as antifungal agents显示文摘A series of 1-(benzylamino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-l-yl)propan-2-ols compounds were synthesized and evaluated for their antifungal activities in vitro.The results showed that compounds 6A and 6B exhibited good antifungal activity.Compound 6A8 showed the strongest antifungal activity,which was significantly higher than that of the lead compounds and positive-control drugs Fluconazole and Itraconazole.In particular,the antifungal activity of compound 6A8 against Candida albicans and Candida krusei(MIC80 both at 0.00097μg/mL) was 515 and 64 times that of Fluconazole,respectively.The structure-activity relationships of the synthesized compounds were discussed,and the docking model of the target compounds with fungal lanosterol 14α-demethylase (CYP51) was analyzed. | Hui Tang Can-Hui Zheng Xiao-Hui Ren Jia Liu Na Liu Jia-Guo Lv Ju Zhu You-Jun Zhou | 2013 | Chinese Chemical Letters2013，24，3： | 6 |
| 19 | Efficacy of structured education in patients with type 2 diabetes mellitus receiving insulin treatment (结构化教育对接受胰岛素治疗的2型糖尿病患者的效果)显示文摘 | Xiao Hui Guo Li Nong Ji Ju Ming Lu Jie Liu Qing Qing Lou Jing Liu Li Shen Ming Xia Zhang Xiao Feng Lv Ming Jun Gu | 2014 | Journal of Diabetes2014，，4： | 5 |
| 20 | Genetic and Antibiotic Resistance Characteristics ofCampylobacterjejuni Isolated from Diarrheal Patients,Poultry and Cattle in Shenzhen显示文摘Objective To investigate genetic and antibiotic resistance characteristics of Campylobacter jejuni(C. jejuni) isolated from Shenzhen. Methods Multilocs sequence typing and agar dilution methods were used to define the genotype and antibiotic resistance of C. jejuni, respectively. Results In total, 126 C. jejuni strains were isolated. The prevalence of C. jejuni was 5.3% in diarrheal patients. The prevalence in poultry meat(36.5%) was higher than that in cattle meat(1.1%). However, the prevalence in poultry cloacal swabs(27.0%) was lower than that in cattle stool(57.3%). Sixty-two sequence types were obtained, among which 27 of the STs and 10 alleles were previously unreported. The most frequently observed clonal complexes were ST-21(11.9%), ST-22(10.3%), and ST-403(7.1%). ST-21, ST-45, ST-354, ST-403, and ST-443 complexes overlapped between isolates from patients and cattle, whereas ST-45 and ST-574 complexes overlapped between isolates from patients and poultry. All C. jejuni were resistant to at least one antibiotic. The highest resistance rate was toward ciprofloxacin(89.7%), followed by tetracycline(74.6%), and nalidixic acid(69.0%). Conclusion This is the first report of the genotypes and antibiotic resistance of C. jejuni in Shenzhen. Overlapping clonal complexes were found between isolates from patients and cattle, and between patients and poultry. | JU Chang Yan ZHANG Mao Jun MA Yan Ping LU Jing Rang YU Mu Hua CHEN Hui LIU Chu Yun GU Yi Xin FU Yan Yan DUAN Yong Xiang | 2018 | Biomedical and Environmental Sciences2018，31，8： | 5 |
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