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| 1 | Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements显示文摘Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating factors.Each of the various strategies currently employed to face these scourges is seriously inadequate.Despite enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented.Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden.Nowadays,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently used.The recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease. | Denis Zofou Raymond B Nyasa Dickson S Nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete | 2014 | Infectious Diseases of Poverty2014，3，1： | 4 |
| 2 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 3 |
| 3 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 4 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 2 |
| 5 | Molticenter study for lamivudine therapy for hepatitis B after liver显示文摘 | Robert P Jorge R Jules D | 1998 | Transpl Surg1998，4，56： | 1 |
| 6 | Effectiveness ofhormonal and surgical therapies for cryptorchidism : a systematicreview 显示文摘 | Penson D Krishnaswami S Jules A | 2013 | Pediatrics2013，131，6： | 1 |
| 7 | Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535-538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis显示文摘 | Jules J Shi Z Liu J Xu D Wang S Feng X | | 0，，： | 1 |
| 8 | Application of membrane enhanced biomass retention to the anaerobic treatment of acidified wastewaters under extreme saline conditions显示文摘 | Jeison D Kremer B Jules B | 2008 | Sep Purif Technol2008，64，2： | 1 |
| 9 | Molecular mechanisms of the biphasic effects of interferongamma on osteoclastogenesis显示文摘 | Cheng J L iu J S hi Z Jules J X u D L uo S W ei S F eng X | | 0，，： | 1 |
| 10 | Spread of an invasive pathogen over a variable landscape:a nonnative root rot on Port Oxford cedar显示文摘 | Jules E S Kauffman M J Ritts W D | 2002 | Ecology2002，83，11： | 1 |
| 11 | Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B显示文摘 | Young-Oh Kweon Zachary D Goodman Jules L Dienstag Eugene R Schiff Nathaniel A Brown Elmar Burkhardt Robert Schoonhoven David A Brenner Michael W Fried | 2001 | Journal of Hepatology2001，，： | 1 |
| 12 | Studies in phosphate bonding显示文摘 | Martin J O Jules J D | 1972 | Ceramic Bulletin1972，51，7： | 1 |
| 13 | Cytornegalovirus pneumonia after bone marrow transplantation successfully treated with the combination of ganciclovir and high dose intravenous immune globulin 显示文摘 | Emanuel D Cunningham J Jules Elysec K | 1988 | Ann Intern Med1988，109，10： | 1 |
| 14 | A model-based comparison of under- water imaging systems显示文摘 | Jules S J Chris D | 1988 | Ocean Optics1988，，： | 1 |
| 15 | Long-term safety of lamivudine treatment in patients with chronic hepatitis B显示文摘 | Anna S.F Lok Ching-Lung Lai Nancy Leung Guang-Bi Yao Zhen-Yu Cui Eugene R Schiff Jules L Dienstag E.Jenny Heathcote Nancy R Little Dorothea A Griffiths Stephen D Gardner Mary Castiglia | 2003 | Gastroenterology2003，，6： | 1 |
| 16 | In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life显示文摘 | JULES G E PRATAP S RAMESH A HOOD D B | | 0，，1： | 1 |
| 17 | High expression of GCLC is associated with malignant melanoma of low oxidative phenotype and predicts a better prognosis显示文摘 | Dimitrios Mougiakakos Riki Okita Takashi Ando Christoph Dürr Jules Gadiot Jiro Ichikawa Robert Zeiser Christian Blank C. Johansson Rolf Kiessling | 2012 | Journal of Molecular Medicine2012，，8： | 1 |
| 18 | Phage display selects for amylases with improved low pH starchbinding显示文摘 | RAYMOND M D V JULES B RENIE O | 2002 | Journal of Biotechnology2002，96，1： | 1 |
| 19 | Evolution of the New Pathway curiculum at Harvard Medical School 显示文摘 | Jules L D | 2011 | Perspectives in Biology and Medicine2011，54，： | 1 |
| 20 | Comparative inhibitory activity of etoricoxib, celecoxib, and diclofenac on COX-2 Versus COX-I in healthy subjects 显示文摘 | JULES I SCHWART Z PHAR M D | 2008 | J Clin Pharmacol2008，48，： | 1 |
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