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| 1 | CD4^+ T cell-mediated presentation of non-infectious HIV-1 virion antigens to HIV-specific CD8^+ T cells显示文摘Background The mechanism of chronic immune activation and impairment of HIV-specific immune responses during chronic infection is not fully understood. However, it is known that high immune activation leads to more rapid progression to AIDS. We hypothesize that CD4+ T cell-mediated viral antigen presentation contributes to this pathologic immune activation in HIV-infected individuals. Methods HIV-specific T cells, responding to noninfectious HIV-1 virions as antigen, were measured by flow cytometric assays. These experimental conditions reflect the in vivo condition where noninfectious HIV-1 represents more than 99% of the antigens. Results CD4+ T cells purified from HIV-infected individuals were capable of cross presenting exogenous noninfectious HIV-1 virions to HIV-1-specific CD8+ T cells. Cross presentation required the entry of HIV-1 to CD4+ T cells and antigen translocation from endoplasmic reticulum to the Golgi complex. Blocking CD4+ mediated activation of HIV-specific CD8+ T cells and redirecting the viral antigens to antigen presenting cells improved HIV-specific T cell responses. Conclusions One possible cause of chronic immune activation and impairment of HIV-1 specific T cell responses is represented by HIV-1 harboring CD4+ T cells cross presenting HIV-1 antigen to activate CD8+ T cells. This new mechanism provides the first evidence that cross presentation of noninfectious HIV-1 virions play a role in the immunopathogenesis of HIV-1 infection. | XU Jian-qing Franco Lori Julianna Lisziewicz | 2006 | Chinese Medical Journal2006，，19： | 3 |
| 2 | Therapeutics administered during ex vivo liver machine perfusion:An overview显示文摘Although the use of extended criteria donors has increased the pool of available livers for transplant,it has also introduced the need to develop improved methods of protection against ischemia-reperfusion injury(IRI),as these'marginal'organs are particularly vulnerable to IRI during the process of procurement,preservation,surgery,and post-transplantation.In this review,we explore the current basic science research investigating therapeutics administered during ex vivo liver machine perfusion aimed at mitigating the effects of IRI in the liver transplantation process.These various categories of therapeutics are utilized during the perfusion process and include invoking the RNA interference pathway,utilizing defatting cocktails,and administering classes of agents such as vasodilators,anti-inflammatory drugs,human liver stem cell-derived extracellular vesicles,and δ-opioid agonists in order to reduce the damage of IRI.Ex vivo machine perfusion is an attractive alternative to static cold storage due to its ability to continuously perfuse the organ,effectively deliver substrates and oxygen required for cellular metabolism,therapeutically administer pharmacological or cytoprotective agents,and continuously monitor organ viability during perfusion.The use of administered therapeutics during machine liver perfusion has demonstrated promising results in basic science studies.While novel therapeutic approaches to combat IRI are being developed through basic science research,their use in clinical medicine and treatment in patients for liver transplantation has yet to be explored. | Julianna E Buchwald Jing Xu Adel Bozorgzadeh Paulo N Martins | 2020 | World Journal of Transplantation2020，10，1： | 3 |
| 3 | Putting On The Breaks:Regulating Organelle Movements in Plant Cells显示文摘A striking characteristic of plant cells is that their organelles can move rapidly through the cell.This movement,commonly referred to as cytoplasmic streaming,has been observed for over 200 years,but we are only now beginning to decipher the mechanisms responsible for it.The identification of the myosin motor proteins responsible for these movements allows us to probe the regulatory events that coordinate organelle displacement with normal cell physiology.This review will highlight several recent developments that have provided new insight into the regulation of organelle movement,both at the cellular level and at the molecular level. | Julianna K.Vick Andreas Nebenfhr | 2012 | Journal of Integrative Plant Biology2012，54，11： | 2 |
| 4 | Gender-Typed Play Behavior in Early Childhood: Adopted Children with Lesbian, Gay, and Heterosexual Parents显示文摘 | Abbie E. Goldberg Deborah A. Kashy JuliAnna Z. Smith | 2012 | Sex Roles2012，，9： | 2 |
| 5 | Analysis of optic disc damage by optical coherence tomography in terms of therapy in non-arteritic anterior ischemic optic neuropathy显示文摘This study aimed to assess the relationship between the rate of nerve fiber loss in non-arteritic anterior ischemic optic neuropathy(NAION) and time delay before therapy.Total 24 patients received the same treatment within or after 2wk(early and late groups).There were significantly lower level of destruction of nerve fibers(P=0.0014) and significantly better visual field sensitivity(P=0.039) in early group.The results indicate that therapy should be started within 2wk.The degree of ischemic damage due to NAION correlates well with retinal nerve fiber layer thickness and the ischemia-induced decrease in visual field sensitivity. | Zsuzsa Balogh Marta Kasza Julianna Varadai Izabella Reznek Judit Damjanovich Adrienne Csutak Andras Berta Valeria Nagy | 2016 | International Journal of Ophthalmology(English edition)2016，9，9： | 2 |
| 6 | Understanding and promoting resilience in children and youth显示文摘 | Julianna K Sapienza Ann S Masten | 2011 | Current Opinion in Psychiatry2011，，4： | 1 |
| 7 | Interaction of the antidepressant mirtazapine with α 2 -adrenoceptors modulating the release of 5-HT in different rat brain regions in vivo显示文摘 | H. J?rgen Bengtsson Julianna Kele Johan Johansson Stephan Hjorth | 2000 | Naunyn-Schmiedeberg’s Archives of Pharmacology (-)2000，，4： | 1 |
| 8 | Stevens, fabrication of a super-hydrophobic polypropylene membrane by deposition of a porous crystalline polypropylene coating显示文摘 | Julianna A Sandra E Jilska M | 2008 | J Membr Sci2008，318，： | 1 |
| 9 | Recent advances in GABA research显示文摘 | JULIANNA K | 1999 | Nenroehem lnt1999，34，： | 1 |
| 10 | Assessment of natural resources for nature-based tourism:the case of the Central Coast Region of Western Australia显示文摘 | Julianna Priskin | 2001 | Tourism Management2001，22，6： | 1 |
| 11 | Lung nodule detection on chest CT:Evaluation of a computer-aided detection (CAD) system显示文摘 | Gordon G Julianna C | 2005 | NY Korean J Radiol2005，6，2： | 1 |
| 12 | Antisense oligodeoxy-nucleotide phosphorothioate complementary gag mRNA blocks replication of human immunodeficiency virus type1 in human peripheral blood cell显示文摘 | Julianna L Daisy S Frank F | 1994 | Proc Natl Acad Sci U S A1994，91，17： | 1 |
| 13 | Perspectives on the social psychology of creativity显示文摘 | Amabile TM Julianna P | 2012 | Journal of Creative Behavior2012，46，1： | 1 |
| 14 | Recent advances in GABA research 显示文摘 | Julianna K | 1999 | Neurochen Int1999，34，： | 1 |
| 15 | Assessment for natural resources for nature-based tourism: the case of the central coast region of western Australia 显示文摘 | Julianna Priskin | 2001 | Tourism Management2001，22，： | 1 |
| 16 | Assessment of natural resources for nature - based tourism : the case of the Central Coast Region of Western Australia 显示文摘 | Julianna Priskin | 2001 | Tourism Management2001，，22： | 1 |
| 17 | Assessment of Natural Resources for nature - based tourism: the case of the central coast region of western Australia 显示文摘 | Julianna Priskin | 2001 | Tourism Management2001，22，6： | 1 |
| 18 | Bending and Coupling lsses in Terahertz Wire Waveguides 显示文摘 | Victoria Astley Julianna Scheiman Rajind Mendis | 2010 | Optics lzettr2010，35，4： | 1 |
| 19 | Optimization of pH value and aluminium sulphate quantity in the chemical treatment of molass显示文摘 | Ljubinko L Julianna G | 2004 | European Food Research and Technology2004，220，1： | 1 |
| 20 | RAPD typing ofmethicillin-resistant Staphylococcus aureus:a 7-year ex-perience in a Polish hospital显示文摘 | Julianna K Mariusz G Krzysztof J | 2007 | Med Sci Monit2007，13，6： | 1 |
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