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| 1 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 2 | Partial characterization of buckwheat starch显示文摘 | June Qian Patricia Rayas-Duarte Lin da Grant | 1998 | Cereal Chemistry1998，75，3： | 1 |
| 3 | Partial characterization of buckwheat starch显示文摘 | June Qian Patricia Rayas-Duarte Lin da Grant | 1998 | Cereal Chemistry1998，75，3： | 1 |
| 4 | A high performance electrochemical sensor for acetaminophen based on single-walled carbon nanotube-graphene nanosheet hybrid films显示文摘 | Xu Chen June Zhu Qian Xi | 2012 | Sensors and Actuators B2012，161，： | 1 |
| 5 | Partial characterization of buckwheat (Fagopyrum esculentum) starch显示文摘 | June Qian Patricia Rayas-Duarte Lin da Grant | 1998 | Cereal Chem1998，75，3： | 1 |
| 6 | Partial characterization of buckwheat starch 显示文摘 | June Qian Patricia Rayas-Duarte Lin da Grant | 1998 | Cereal Chem1998，75，3： | 1 |
| 7 | Partial Characterization of Buckwheat Starch 显示文摘 | June Qian Patricia Rayas-Duarte Lin da Grant | 1998 | Cereal Chem1998，75，3： | 1 |
| 8 | Partial characterization of buckwheat (Fagopyrum esculentum) starch显示文摘 | Qian June Rayas-Duarte P Grant L | 1998 | Ce- real Chemistry1998，75，3： | 1 |
| 9 | Partial characterization of bukwheat (fagopyrum esculentum) Strach 显示文摘 | Partricia Rayas-Duarte Lind Grant | 1998 | Cereal Chemical1998，75，3： | 1 |
| 10 | Management of the neck after chemoradiotherapy for head and neck cancers in Asia: consensus statement from the Asian Oncology Summit 2009显示文摘 | Joseph T Wee Benjamin O Anderson June Corry Anil D’Cruz Khee C Soo Chao-Nan Qian Daniel T Chua Rodney J Hicks Christopher HK Goh James B Khoo Seng C Ong Arlene A Forastiere Anthony T Chan | 2009 | Lancet Oncology2009，，11： | 1 |
| 11 | Partial characterization of buckwheat (Fagopyrum esculentum) starch显示文摘 | June Qian Patricia Rayas Linda Grant | 1998 | Cereal Chem1998，75，3： | 1 |
| 12 | A high performance electrochemical sensor for acetanlinophen based on single-walled carbon nanotube-graphene nanosheet hybrid films显示文摘 | CHEN Xu ZHU June XI Qian | 2012 | Sensors and Actuators B: Chemical2012，161，1： | 1 |
| 13 | Partial characterization of buckwheat (Fagopyrum esculentum) starch显示文摘 | June Qian Patricia Rayas Linda Grant | 1998 | Cereal Chem1998，75，3： | 1 |
| 14 | Shifting focus from bacteria to host neutrophil extracellular traps of biodegradable pure Zn to combat implant centered infection显示文摘The widespread use of orthopedic implants to support or replace bones is increasingly threatened by the risk of incurable bacterial infections,impenetrable microbial biofilms,and irreversible antibiotic resistance.In the past,the development of anti-infective biomaterials focused solely on direct antibacterial properties while ignoring the host’s immune response.Inspired by the clearance of infection by the innate neutrophil response and partici-pation in anti-infectious immunity of Zn ions,we report an innovative neutrophil extracellular traps(NETs)strategy,induced by biodegradable pure Zn,which achieved therapeutic efficacy toward biomaterial-related infections.Our in vitro and in vivo data showed that pure Zn was favorable for NETs formation by promoting the release of DNA fibers and granule proteins in a reactive oxygen species(ROS)-dependent manner,thereby retraining and degrading bacteria with an efficiency of up to 99.5%.Transcriptome analysis revealed that cytoskeletal rearrangement and toll-like receptor(TLR)signaling pathway were also involved in Zn-induced NETs formation.Furthermore,the in vivo results of a Staphylococcus aureus(S.aureus)-infected rat model veri-fied that pure Zn potentiated the bactericidal capability of neutrophils around implants,and promoted osseointegration in S.aureus-infected rat femurs.This antibacterial immunity concept lays a foundation for the development of other antibacterial biomaterials and holds great promise for treating orthopedic infections. | Feng Peng Juning Xie Haiming Liu Yufeng Zheng Xin Qian Ruixiang Zhou Hua Zhong Yu Zhang Mei Li | 2023 | Bioactive Materials2023，，3： | 0 |
| 15 | Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration显示文摘Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone de-fects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvi-ronment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys. | Dongdong Zhang Shi Cheng Ji Tan Juning Xie Yu Zhang Shuhan Chen Huihui Du Shi Qian Yuqing Qiao Feng Peng Xuanyong Liu | 2022 | Bioactive Materials2022，7，11： | 0 |
| 16 | Study on mineral structural stability of marine 1nm manganate显示文摘In order to study the phase transformation between 1nm manganate and 0.7nm manganate, a series of Slum Me2+ manganates were made after the synthetic 1nm Na+ manganate substituted with different kinds of divalent cations. The X-ray diffraction analysis of wet S1nm Me2+ manganates after 24 h room temperature dry showed that their basal d-spacing had been changed, indicating that there was phase transformation between 1nm and 0.7nm manganates. Take 1nm manganates with unstable structure collapsed into 0. 7nm manganate by losing one interlayer OH-H2O, while those with stable structure still retained the 1nm d-spacing. This factor reminds us that the manganese nodule samples must be kept in wet condition to avoid the misleading results. The structural stabdity of 1nn manganate is mainly controlled by the interlayer divalent cations. There is a possitive correlation between the amount of cations in the interlayer and the structural stability, while the capacity of different canons in stabilizing the structure of 1nm manganate is as follows: Ni > Cu > Co > Zn > Ca>Mg > Na. | Qian Jiangchu 1. Second Insititute of Oceanography, State Oceanic Administration, Hangzhou 310012, China (Received June 24, 1996 accepted March 3, 1998) | 1999 | Acta Oceanologica Sinica1999，18，2： | 0 |
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