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| 1 | CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6显示文摘睫是毛一般的细胞器从房间表面延长与重要感觉并且活动性功能。睫的缺点能导致作为 ciliopathies 知道的大量人的疾病。然而,控制 ciliogenesis 的分子的机制仍然保持糟糕定义。这里,我们显示出那 cylindromatosis (CYLD ) ,怀有 deubiquitinase 活动的肿瘤 suppressor 蛋白质,在多重机关在主要、能动的睫的集会起一个关键作用。CYLD 猛烈老鼠 polydactyly 展出并且各种各样的睫的缺点,例如在基础身体抛锚和基础身体和 axenomes 的组织的破坏的失败。CYLD 的睫的功能部分从 70 kDa (Cep70 ) 的 centrosomal 蛋白质被归因于它 polyubiquitin 链的 deconjugation,为 Cep70 到的一个要求与 γ 交往;导管素并且在中心体本地化。另外, histone deacetylase 的调停 CYLD 的抑制 6 (HDAC6 ) ,它支持导管素 acetylation,为 CYLD 的睫的功能组成另一机制。HDAC6 的小分子的禁止者能部分在 CYLD 猛烈老鼠救睫的缺点。这些调查结果在 ciliogenesis 的调整强调蛋白质 ubiquitination 的重要性,作为这个过程的一个关键管理者识别 CYLD,并且建议在 ciliopathies 的 CYLD 缺乏的参与。 | Yunfan Yang Jie Ran Min Liu Dengwen Li Yuanyuan Li Xingjuan Shi Dan Meng Junmin Pan Guangshuo Ou Rim Aneja Sbao-Cong Sun Jun Zhou | 2014 | Cell Research2014，24，11： | 8 |
| 2 | Cilia and ciliopathies:From Chlamydomonas and beyond显示文摘The biological function of motile cilia/flagella has long been recognized. The non-motile primary cilium, once regarded as a vestigial organelle, however, has been found recently to play unexpected roles in mammalian physiology and development. Defects in cilia have profound impact on human health. Diseases related to cilia, collectively called ciliopathies include male infertility, primary cilia dyskinesia, renal cyst formation, blindness, polydactyly, obesity, hypertension, and even mental retardation. Our current understanding of cilia and ciliopathies has been fueled by basic research employing various model organisms including Chlamydomonas, a unicellular green alga. This review article provides a general introduction to the cell biology of cilia and an overview of various cilia-related diseases. | PAN JunMin Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China | 2008 | Science China(Life Sciences)2008，51，6： | 3 |
| 3 | A shiRed SVPWM method to control DC-link resonant inverters and its FPGA realization显示文摘 | Pan Sanbo Pan Junmin Tian Zuohua | 2012 | IEEE Transactions on Industrial Electronics2012，59，9： | 1 |
| 4 | The Phosphorylation State of an Aurora-Like Kinase Marks the Length of Growing Flagella in Chlamydomonas显示文摘 | Minna Luo Muqing Cao Yinan Kan Guihua Li William Snell Junmin Pan | 2011 | Current Biology2011，，7： | 1 |
| 5 | Chlamydomonas shortens its flagella by activating axonemal disassembly,stimulating IFTparticle trafficking,and blocking anterograde cargo loading显示文摘 | Junmin Pan William J Snell | 2005 | Developmental Cell2005，9，： | 1 |
| 6 | A shifted SVPWM method to control DC-link resonant inverters and its FPGA realization显示文摘 | Pan Sanbo Pan Junmin Tian Zuohua | | 0，，09： | 1 |
| 7 | Structural elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus显示文摘 | Fan Junmin Zhang Jingsong Tang Qingjiu Liu Yanfang Zhang Anqiang Pan Yingjie | 2006 | Carbohydrate Research2006，341，9： | 1 |
| 8 | A shifted SVPWM method to control DC-link resonant inverters and its FPGA realization显示文摘 | Pan Sanbo Pan Junmin Tian Zuohua | 2012 | IEEE Transactions on Industrial Electronics2012，59，9： | 1 |
| 9 | A shifted SVPWM method to control DC-link resonant inverters and its FPGA realization 显示文摘 | Sanbo Pan Junmin Pan Zuohua Tian | 2012 | IEEE Transactions on Industrial Electronics2012，59，9： | 1 |
| 10 | Chlamydomonas WDR92 in association with R2TP-like complex and multiple DNAAFs to regulate ciliary dynein preassembly显示文摘The motility of cilia or eukaryotic flagella is powered by the axonemal dyneins,which are preassembled in the cytoplasm by proteins termed dynein arm assembly factors(DNAAFs)before being transported to and assembled on the ciliary axoneme.Here,we characterize the function of WDR92 in Chlamydomonas.Loss of WDR92,a cytoplasmic protein,in a mutant wdr92 generated by DNA insertional mutagenesis resulted in aflagellate cells or cells with stumpy or short flagella,disappearance of axonemal dynein arms,and diminishment of dynein arm heavy chains in the cytoplasm,suggesting that WDR92 is a DNAAF.Immunoprecipitation of WDR92 followed by mass spectrometry identified inner dynein arm heavy chains and multiple DNAAFs including RuvBLl,RPAP3,MOT48,ODA7,and DYX1C.The PIH1 domain-containing protein MOT48 formed a R2TP-like complex with RuvBLl/2 and RPAP3,while PF13,another PIH1 domain-containing protein with function in dynein preassembly,did not.Interestingly,the third PIH1 domain-containing protein TWI1 was not related to flagellar motility.WDR92 physically interacted with the R2TP-like complex and the other identified DNNAFs.Our data suggest that WDR92 functions in association with the HSP90 co-chaperone R2TP-like complex as well as linking other DNAAFs in dynein preassembly. | Guang Liu Limei Wang Junmin Pan | 2019 | Journal of Molecular Cell Biology2019，11，9： | 0 |
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