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| 1 | Nonfunctional alleles of long-day suppressor genes independently regulate flowering time显示文摘Due to the remarkable adaptability to various environments, rice varieties with diverse flowering times have abeen domesticated or improved from Oryza rufipogon.Detailed knowledge of the genetic factors controlling flowering time will facilitate understanding the adaptation mechanism in cultivated rice and enable breeders to design appropriate genotypes for distinct preferences. In this study,four genes(Hd1, DTH8, Ghd7 and OsPRR37) in a rice long-day suppression pathway were collected and sequenced in 154, 74,69 and 62 varieties of cultivated rice(Oryza sativa)respectively. Under long-day conditions, varieties with nonfunctional alleles flowered significantly earlier than those with functional alleles. However, the four genes have different genetic effects in the regulation of flowering time: Hd1 and Os PRR37 are major genes that generally regulate rice flowering time for all varieties, while DTH8 and Ghd7 only regulate regional rice varieties. Geographic analysis and network studies suggested that the nonfunctional alleles of these suppression loci with regional adaptability were derived recently and independently. Alleles with regional adaptability should be taken into consideration for genetic improvement. The rich genetic variations in these four genes,which adapt rice to different environments, provide the flexibility needed for breeding rice varieties with diverse flowering times. | Xiao-Ming Zheng Li Feng Junrui Wang Weihua Qiao Lifang Zhang Yunlian Cheng Qingwen Yang | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
| 2 | Preparation,structural characterization and bioactivities of polysaccharides from mulberry(Mori Fructus)显示文摘Mulberry(Mori Fructus),a highly promising functional food,has long exhibited multiple therapeutic effects as a tonic in traditional Chinese food and pharmacology.Polysaccharides have been regarded as the pivotal pharmacological ingredient in mulberry.In this study,structural characterization and bioactivities of polysaccharides from mulberry(PFM-3)were determined.The results showed that PFM-3 was a pyranose containing carboxyl group,which was mainly composed of glucose(Glc)and a small amount of mannose(Man)and fucose(Fuc).The molecular weight of PFM-3 was 96.17 kDa,and the surface of PFM-3 was compact and uniform crack.PFM-3 markedly decreased lipid accumulation,triglyceride(TG)and low density lipoprotein cholesterin(LDL-C)on hyperlipidemia human hepatocellular carcinoma(HepG2)cells.PFM-3 recovered nuclear morphometry and mitochondrial membrane potential(MMP),enhanced the activity of glutathione peroxidase(GPx)and decreased cell arrest in G2 phase on oxidative stress HepG2 cells.In addition,PFM-3 promoted the decline of tumor necrosis factor-α(TNF-α)and the augment of interleukin-10(IL-10)secretion on inflammatory mouse leukemia cells of monocyte macrophage(RAW 264.7).This work provides a certificate that PFM-3 could markedly improve cellular lipid accumulation,endogenous antioxidant defense capacity and inflammation levels to further use for treatment and amelioration of related diseases. | Yumeng Liu Yiming Liu Delun Mu Hui Yang Ying Feng Ruiqin Ji Rina Wu Junrui Wu | 2022 | Food Bioscience2022，46，2： | 1 |
| 3 | Round-trip oscillation triboelectric nanogenerator with high output response and low wear to harvest random wind energy显示文摘Triboelectric nanogenerator(TENG)has made significant progress in wind energy harvesting.As the most advantageous rotary TENG among wind energy harvesters,the severe material wear and the output that fluctuates with wind speed seriously hinder the application of TENG wind energy harvesters.In this study,we propose a round-trip oscillation triboelectric nanogenerator(RTO-TENG)consisting of a crank transmission mechanism and a power generation unit.The RTO-TENG utilizes a simple crank transmission mechanism combined with a zigzag-laminated triboelectric nanogenerator(Z-TENG)to achieve high-performance constant output and low material wear.The crank transmission mechanism can realize the transformation from circular motion to arc reciprocating motion,converting the random wind energy into bi-directional kinetic energy,driving the vertical contact and separation of the Z-TENG.Due to the low transmission ratio(1:1)of the crank transmission mechanism and the consistent frequency of the Z-TENG contact–separation with that of the pendulum,the RTO-TENG’s power generation unit(10 Z-TENGs)is insensitive to changes in wind speed,resulting in a constant and stable output response at various speeds.After 480,000 cycles,the output of RTO-TENG decreased by only 0.9%compared to the initial value of 6μC,and the scanning electron microscopy(SEM)images of the polytetrafluoroethylene(PTFE)film showed no significant wear on the surface of the friction layer,demonstrating excellent output stability and abrasion resistance of the RTO-TENG wind energy collector’s material.The equipped energy management module,based on a gas discharge tube switch,can further enhance the output performance of the RTO-TENG.After optimizing its inductor parameter L to match the load capacitor,it can charge a 220μF load capacitor to 13.4 V in 40 s,resulting in a 298%improvement in charging speed compared to the voltage of 4.48 V without the management module.Therefore,the RTO-TENG can efficiently provide power to low-power small electronic devices for Internet of Things(IoTs),such as road traffic warning signs and thermo-hygrometers. | Xinyu Hu Junrui Feng Chuangjian Liang Heng Ning Chunjin Chen Jiayu Li Honggui Wen Huilu Yao Lingyu Wan Guanlin Liu | 2023 | Nano Research2023，16，8： | 1 |
| 4 | 3-75 Radiosensitizing Effects of miR-185 on Melanoma Cells显示文摘Melanoma is an aggressive malignancy with high metastasis and low survival rate, of which the incidence rate keeps increasing year by year worldwide while the therapeutic options are still limited up to now[1;2]. Melanoma is considered to be a relatively radioresistant tumor, and radiotherapy has an important role in its treatment, especially in patients with central nervous system metastases[3], so enhancement of cellular radiosensitivity by radiosensitizer is an efficient strategy to improve the outcome of radiotherapy. | He Jinpeng Tian Ning Yang Yanli Jin Liangliang Feng Xiu Hua Junrui Lin Sulan Wang Bing Li He Wang Jufang | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 5 | OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice显示文摘The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental concerns.Increasing the N use efficiency(NUE)of rice varieties is crucial for sustainable agriculture.Here we report the cloning and characterization of OsNPF3.1,a gene that controls rice NUE.An amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated rice.OsNPF3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain weight.The OsNPF3.1 protein is located in the plasma membrane.When OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica rice.OsNPF3.1 can be used as a new target gene for breeding rice varieties with high NUE. | Xinghai Yang Baoxuan Nong Can Chen Junrui Wang Xiuzhong Xia Zongqiong Zhang Yu Wei Yu Zeng Rui Feng Yanyan Wu Hui Guo Haifeng Yan Yuntao Liang Shuhui Liang Yong Yan Danting Li Guofu Deng | 2023 | The Crop Journal2023，11，1： | 0 |
| 6 | 重离子辐射引起的衰老人黑色素瘤细胞产生的衰老相关分泌表型显示文摘Senescence is a cell fate that can be induced by intra/extracellular stresses such as DNA damage,oncogenic mutations,telomere shorting,and inflammation[1].Senescent cells develop a characteristic secretion profile including a range of cytokines,chemokines,proteases,and other factors,which is termed the senescence-associated secretory phenotype(SASP)[2].Accumulating evidence indicates that SASP factors provoke multiple chronic diseases,even tumorigenesis and aggressiveness[3].Our recent studies reveal that heavy ion could induce senescence with lower dose than X-ray in various tumor cells[4;5].However,very little is known about the SASP of senescent tumor cells induced by heavy ions.In the present study,human melanoma cell line 92-1 cells were exposed to 10 Gy of carbon ion beams or X-rays,respectively.The cell culture supernatants were harvested 3 days post-irradiation,and the SASP were measured using human antibody arrays including 507 factors. | He Jinpeng Hua Junrui Long Kaiqing Feng Xiu Wei Wenjun Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 7 | 蛇床子素通过抑制mir-34c表达防治尾吊大鼠模拟微重力导致的骨质流失显示文摘Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear. | Feng Xiu He Jinpeng Hua Junrui Long Kaiqin Zhang Yanan Wang Jufang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | Exploring the abundance and influencing factors of antimicrobial resistance genes in manure plasmidome from swine farms显示文摘Plasmids play a critical role in the dissemination of antimicrobial resistance genes(ARGs),however,a systematical understanding of ARGs originated from plasmids in swine production is currently lacking.Herein,quantitative polymerase chain reaction was applied to determine the prevalence of ten ARGs and the class1 integron gene intI1 of plasmid source in swinemanure from 44 farms in Sichuan,Hubei and Hebei provinces,China.All assayed ARGs were observed in plasmid DNA samples,and the average absolute abundance of aac(6’)-Ib-cr,blaNDM,blaCTX-M,optrA,ermB,floR,mcr-1,qnrS,tetM,sul1 and intI1 were 7.09,2.90,4.67,6.62,7.55,7.14,4.08,4.85,7.16,7.11 and 8.07 of 10 log copies/gram,respectively.IntI1 showed a high correlation(r>0.8,P<0.01)with the abundance of aac(6’)-Ib-cr and sul1 in swine manure.Moreover,the farm scale(i.e.,herd population)and geographical location were not found to be critical factors influencing the absolute abundance of ARGs of plasmid DNA in swine farms.However,the concentrations of florfenicol,Cu,Zn,Fe,total phosphorus(TP)and total potassium(TK)demonstrated a significant correlation with the abundance of several ARGs.Particularly,Cu and Zn had high correlations with optrA and blaCTX-M,respectively.Our results demonstrated that antibiotics,heavy metals and environmental nutrients are likely jointly contributing to the long-term persistence of ARGs in swine production.This study provides insights into the abundance and influencing factors of ARGs from swine manure,which is of significance for assessing and reducing the public health risks in livestock production. | Zunfang Tu Junrui Shui Jinxin Liu Hongmei Tuo Haoyu Zhang Cong Lin Jingyi Feng Yuxuan Feng Wen Su Anyun Zhang | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 9 | 淫羊藿苷通过提高骨磷灰石稳定性抵御尾吊大鼠骨流失显示文摘Bone metabolism derangement induced by space microgravity is severe threaten to the health of astronauts[1].Exercise is the primary countermeasure in long-duration spaceflights,despite the outcomes remain debatable[2,3].In addition,pharmacological interventions cannot be used to protect against the osteoporosis induced by space environment due to various side effects[4,5]. | He Jinpeng Feng Xiu Shi Wengui Hua Junrui Li He Wang Jufang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 10 | miR-300靶向apaf1降低电离辐射引发p53突变型肺癌细胞的凋亡显示文摘microRNAs(miRNAs)play important roles in the cellular response to ionizing radiation(IR)through regulating key mediators of DNA damage response pathways,such as ATM[1]and ATR[2].It has been revealed that miR-300 is involved in the cellular chemo-and radio-resistance in ovarian and gastric cancers[3,4].In recent study,we found that miR-300 abrogated IR-induced G2 cell cycle arrest in human lung cancer cells through targeting p53[5].However,the effects of miR-300 on the cellular sensitivity to IR in p53 mutant cells still need further investigation。 | He Jinpeng Feng Xiu Hua Junrui Wei Wenjun Wang Jufang | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 11 | 4-67 miR-300 Modulates the Cellular Radiosensitivity Through Targeting p^53 in Human Non-small Cell Lung Cancer A549 Cells显示文摘microRNAs(miRNAs)perform crucial roles in mediation of the cellular radiosensitivity by influencing DNA damage repair,cell cycle checkpoint,apoptosis,radio-related signal transduction pathway and microenvironment[1-3].Our previous study have suggested that miR??300,whose expression is correlated positively with the cellular resistance to chemotherapy drug cis-platin in human ovarian cancer cells[4],is involved in the cellular response to the DNA damages induced by ionizing radiation[5].However,the underlying molecular mechanisms remain unclear. | He Jinpeng Wei Wenjun Feng Xiu Hua Junrui Lu Zhiwei Jin Liangliang Ding Nan Zhang Yanan Li He Wang Jufang | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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