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| 1 | Recent Progress Using High-throughput Sequencing Technologies in Plant Molecular Breeding显示文摘High-throughput sequencing is a revolutionary technological innovation in DNA sequencing.This technology has an ultra-low cost per base of sequencing and an overwhelmingly high data output.High-throughput sequencing has brought novel research methods and solutions to the research fields of genomics and post-genomics.Furthermore,this technology is leading to a new molecular breeding revolution that has landmark significance for scientific research and enables us to launch multi-level,multi-faceted,and multi-extent studies in the fields of crop genetics,genomics,and crop breeding.In this paper,we review progress in the application of high-throughput sequencing technologies to plant molecular breeding studies. | Qiang Gao Guidong Yue Wenqi Li Junyi Wang Jiaohui Xu Ye Yin | 2012 | Journal of Integrative Plant Biology2012，54，4： | 15 |
| 2 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 3 | Expression of ipt gene driven by tomato fruit specific promoter and its effects on fruit development of tomato显示文摘Fruit specific promoter (2A12) from Lycopersi-com esculentum and cDNA of isopentenyl-transferase (ipt) from Ti plasmid of Agrobacterium tumerfaciens C58 were cloned by PCR procedure respectively. Two plant expression vectors with 2A12/gus or 2A12/ipt were respectively constructed. These two chimeric genes were transferred into tomato by Agrobacterium mediated procedure. The results of Southern hybridization showed that the fusion genes had been integrated into tomatoes. The result of gus histochemi-cal staining showed that 2A12 had high fruit specific expressive capability in transgenic tomato. The ipt expression resulted in accumulation of high level of cytokinins (CTKs) in fruit lead to developmental changes in fruits and seeds. The fruit of ipt transformed tomato had the hyperplastic placenta with very few seeds or even seedless. The shelf life of transgenic fruits elongated for 1-2 weeks. The ratio of fruit set, the dry weight of fruit and the crude protein content in fruit were increased, while | Zichao Mao Qiuju Yu Wei Zhen Junyi Guo Yuanlei Hu Yin Gao Zhongping Lin | 2002 | Chinese Science Bulletin2002，47，11： | 6 |
| 4 | Vitamin C promotes the proliferation and effector functions of human γδ T cells显示文摘γδT cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell types.Potential applications include the adoptive transfer of in vitro-expandedγδT cells.Therefore,it is important to optimize the culture conditions to enable maximal proliferative and functional activity.Vitamin C(L-ascorbic acid)is an essential vitamin with multiple effects on immune cells.It is a cofactor for several enzymes,has antioxidant activity,and is an epigenetic modifier.Here,we investigated the effects of vitamin C(VC)and its more stable derivative,L-ascorbic acid 2-phosphate(pVC),on the proliferation and effector function of humanγδT cells stimulated with zoledronate(ZOL)or synthetic phosphoantigens(pAgs).VC and pVC did not increaseγδT-cell expansion within ZOL-or pAg-stimulated PBMCs,but increased the proliferation of purifiedγδT cells and 14-day-expandedγδT-cell lines in response toγδT-cell-specific pAgs.VC reduced the apoptosis ofγδT cells during primary stimulation.While pVC did not prevent activation-induced death of pAg-restimulatedγδT cells,it enhanced the cell cycle progression and cellular expansion.Furthermore,VC and pVC enhanced cytokine production during primary activation,as well as upon pAg restimulation of 14-day-expandedγδT cells.VC and pVC also increased the oxidative respiration and glycolysis ofγδT cells,but stimulus-dependent differences were observed.The modulatory activity of VC and pVC might help to increase the efficacy ofγδT-cell expansion for adoptive immunotherapy. | Léonce Kouakanou Yan Xu Christian Peters Junyi He Yangzhe Wu Zhinan Yin Dieter Kabelitz | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 5 | Spatially continuous transformer online temperature monitoring based on distributed optical fibre sensing technology显示文摘Transformer internal thermal monitoring exists huge blind areas,and it is difficult for traditional methods to get fully distributed temperature in real time.In this contri-bution,the distributed optical fibre sensor was creatively applied inside an operating 35 kV oil‐immersed transformer which is also qualified for actual power grid oper-ation through the ex‐factory tests.Furthermore,the full‐region temperature along the windings and iron limbs were firstly monitored in a spatiotemporally continuous manner and the hotspots were also closely traced,fluctuating at 90%of the high‐voltage winding height(80%for low‐voltage winding)during the whole process of the heat‐run test.Corresponding Finite Element Method(FEM)for thermo‐fluid field calculation was then utilized for deeper analysis.On the former basis,the actual detected temperature distributions(both spatial and temporal)were compared with the International Electrotechnical Commission traditional model and some modifi-cations were suggested based on the real time measured data.This novel online monitoring application and the detailed internal thermal information may provide a solid reference for the delicate management of power transformers,which also offers a new horizon for the online monitoring in electrical apparatus industry. | Yunpeng Liu Xinye Li Huan Li Junyi Yin Jiaxue Wang Xiaozhou Fan | 2022 | High Voltage2022，7，2： | 1 |
| 6 | The draftgenome of a diploid cotton gossypium raimondii 显示文摘 | Kunbo Wang Zhiwen Wang Fuguang Li Wuwei Ye Junyi Wang Guoli Song Zhen Yue Lin Cong Haihong Shang Shilin Zhu Changsong Zou Qin Li Youlu Yuan Cairui Lu Hengling Wei Caiyun Gou Zequn Zheng Ye Yin Xueyan Zhang Kun Liu Bo Wang Chi Song Nan Shi Russell J Kohel Richard G Percy John Z Yu Yu-xian Zhu Jun Wang Shuxun Yu | 2012 | Nat Genet2012，，44： | 1 |
| 7 | Theory-driven designed TiO_(2)@MoO_(2)heterojunction:Balanced crystallinity and nanostructure toward desirable kinetics and highrate sodium-ion storage显示文摘Sodium-ion batteries(SIBs)are promising candidates for large-scale energy storage due to their cost effectiveness and the unlimited availability of sodium.However,there remains a need for the rational design of better anodic materials than are currently available,as these materials are critical for the sodium-ion storage process.In this work,theoretical calculations were performed to design a conceptually novel TiO_(2)@MoO_(2)heterojunction(TMH)anode that was expected to exhibit better electrochemical performance than current anodes.The TMH anode was fabricated via a facile and cost-effective method,and the results of in-depth sodium-ion-storage performance and reaction kinetics analyses indicate that it exhibited an excellent rate capability and enhanced pseudocapacitive response,due to its high crystallinity.This electrochemical performance was superior to that of previously reported anodic materials,confirming the accuracy of the theoretical calculations.Destruction of TMH’s nanostructure at high temperatures resulted in a decrease in its electrochemical performance,indicating the key role played by the nanostructure in TMH’s ability to store sodium ions.This study demonstrates that integration of theoretical predictions with experimental investigations offers insights into how materials’crystallinity and nanostructure affect their pseudocapacitive sodiumion storage capabilities,which will help to guide the rational design of effective anodic materials for SIBs. | Junyi Yin Pengqi Hai Yuan Gao Zihan Gan Chao Wu Yonghong Cheng Xin Xu | 2023 | Nano Research2023，16，4： | 1 |
| 8 | Bioinspired nanomaterials for wearable sensing and human–machine interfacing显示文摘The inculcation of bioinspiration in sensing and human–machine interface(HMI)technologies can lead to distinctive characteristics such as conformability,low power consumption,high sensitivity,and unique properties like self-healing,self-cleaning,and adaptability.Both sensing and HMI are fields rife with opportunities for the application of bioinspired nanomaterials,particularly when it comes to wearable sensory systems where biocompatibility is an additional requirement.This review discusses recent development in bioinspired nanomaterials for wearable sensing and HMIs,with a specific focus on state-of-the-art bioinspired capacitive sensors,piezoresistive sensors,piezoelectric sensors,triboelectric sensors,magnetoelastic sensors,and electrochemical sensors.We also present a comprehensive overview of the challenges that have hindered the scientific advancement in academia and commercialization in the industry. | Vishesh Kashyap Junyi Yin Xiao Xiao Jun Chen | 2024 | Nano Research2024，17，2： | 1 |
| 9 | Simultaneous regulation on coordination environment and interfacial chemistry via taurine for stabilized Zn metal anode显示文摘Aqueous Zn-ion batteries(AZIBs)are the potential options for the next-generation energy storage scenarios due to the cost effectiveness and intrinsic safety.Nevertheless,the industrial application of AZIBs is still impeded by a series of parasitic reactions and dendrites at zinc anodes.In this study,taurine(TAU)is used in electrolyte to simultaneously optimize the coordination condition of the ZnSO4electrolyte and interfacial chemistry at the anode.TAU can preferentially adsorb with the zinc metal and induce an in situ stable and protective interface on the anode,which would avoid the connection between H_(2)O and the zinc metal and promote the even deposition of Zn^(2+).The resulting Zn//Zn batteries achieve more than 3000 hours long cyclic lifespan under 1 mA cm^(-2)and an impressive cumulative capacity at 5 mA cm^(-2).Moreover,Zn//Cu batteries can realize a reversible plating/stripping process over 2,400cycles,with a desirable coulombic efficiency of 99.75%(1 mA cm^(-2)).Additionally,the additive endows Zn//NH_(4)V_(4)O_(10)batteries with more stable cyclic performance and ultrafast rate capability.These capabilities can promote the industrial application of AZIBs. | Xin Xu Junyi Yin Ruimin Qin Haoliang Liu Xiang Feng Minghui Wang Mingyan Li Weiyu Sun Weichen Shi Bing Xiao Yaqiong Su Yonghong Cheng | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 10 | Zeolite-encaged Ultrasmall Pt-Zn Species with Trace Amount of Pt for Efficient Propane Dehydrogenation显示文摘Propane dehydrogenation(PDH)has become a globe-welcoming technology to meet the massive demand for propylene,but the most commonly used Pt-based catalysts suffer from quick sintering,poor selectivity for propylene,and unsatisfied Pt utilization.Herein,a series of Silicalite-1(S-1)zeolite-encaged ultrasmall Pt-Zn clusters with a trace amount of Pt[40—180 ppm(parts per million)]were developed by using a one-pot ligand-protected direct H_(2) reduction method.Interestingly,the extremely low amount of Pt can significantly promote the activity of zeolite-encaged Zn catalysts in PDH reactions.Thanks to the high Pt dispersion,the synergy between Pt and Zn species,and the confinement effect of zeolites,the optimized PtZn@S-1 catalyst with 180 ppm Pt and 1.88%(mass fraction)Zn,exhibited an extraordinarily high propane conversion(33.9%)and propylene selectivity(99.5%)at 550℃with a weight hourly space velocity(WHSV)of 8 h^(-1),affording an extremely high propylene formation rate of 340.7 mol_(C_(3)H_(6))·g_(Pt^(-1))·h^(-1).This work provides a reference for the preparation of zeolite-encaged metal catalysts with high activity and noble metal utilization in PDH reactions. | QU Ziqiang ZHANG Tianjun YIN Xichen ZHANG Junyi XIONG Xiaoyun SUN Qiming | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 11 | Station of Profibus Communication Board Based on STM32显示文摘In the 250 MeV cyclotron,the communication between the LLRF and control system buses is required.The hardware of the control system is the PLC module,so an embedded IOC board is required as the communication module for the interaction between the control system bus and the low level.The IOC board is an | WEI Junyi LU Xiaotong YIN Zhiguo GONG Pengfei GUO Juanjuan FU Xiaoliang | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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