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3篇 您的检索式:作者名="Junyoung Oh"
    题名 作者 年代 出处 被引量
1Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis显示文摘Rick B. Vega Koichi Matsuda Junyoung Oh Ana C. Barbosa Xiangli Yang Eric Meadows John McAnally Chris Pomajzl John M. Shelton James A. Richardson Gerard Karsenty Eric N. Olson 2004Cell2004,,4:1
2Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis显示文摘Rick B. Vega Koichi Matsuda Junyoung Oh Ana C. Barbosa Xiangli Yang Eric Meadows John McAnally Chris Pomajzl John M. Shelton James A. Richardson Gerard Karsenty Eric N. Olson 2004Cell2004,,4:1
3Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish显示文摘Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical stress.Fish were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to stress.And then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and locomotion.In addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was performed.Results:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.Junyoung Oh Dong Hyun Kim Gi-young Kim Eun-Jin Park Jong Hoon Ryu Ji Wook Jung Se Jin Park Gwang-Woo Kim Seungheon Lee 2020Chinese Journal of Integrative Medicine2020,26,2:0
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