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| 1 | Hidradenitis suppurativa (or Acne inversa) with autosomal dominant inheritance is not linked to chromosome 1p21.1‐1q25.3 region显示文摘 | Faiza MohamedSaleh Al‐Ali UppalaRatnamala Timir Y.Mehta MohammadNaveed Mahmoud T.Al‐Ali NajibAl‐Khaja Jayesh J.Sheth Dilipkumar C.Master Amit K.Maiti Ghati K.Chetan Swapan K.Nath UppalaRadhakrishna | 2010 | Experimental Dermatology2010，，9： | 1 |
| 2 | Recent advances in chemically defined and tunable hydrogel platforms for organoid culture显示文摘Recent developments in organoid culture technologies have made it possible to closely recapitulate intrinsic characteristics of different tissues under in vitro conditions.These organoids act as a translational bridge between the traditional 2D/3D cultures and the in vivo models for studying the tissue development processes,disease modeling,and drug screening.Matrigel and tissue-specific extracellular matrix have been shown to support organoid development,efficiently;however,their chemically undefined nature,non-tunable properties,and associated batch-to-batch variations often limit reproducibility of the assembly process.In this regard,chemically defined platforms offer wider opportunities to optimize and recreate tissue-specific microenvironment.The present review delineates the current research trends in this sphere,focusing on material perspective and the target tissues(e.g.,neural,liver,pancreatic,renal,and intestinal).The review winds up with a discussion on the current limitations and future perspective to provide a basis for future research. | Tarun Agarwal Nehar Celikkin Marco Costantini Tapas K.Maiti Pooyan Makvandi | 2021 | Bio-Design and Manufacturing2021，4，3： | 1 |
| 3 | Engineering biomimetic intestinal topological features in 3D tissue models: retrospects and prospects显示文摘Conventional 2D intestinal models cannot precisely recapitulate biomimetic features in vitro and thus are unsuitable for various pharmacokinetic applications,development of disease models,and understanding the host-microbiome interactions.Thus,recently,efforts have been directed toward recreating in vitro models with intestine-associated unique 3D crypt-villus(for small intestine)or crypt-lumen(for large intestine)architectures.This review comprehensively delineates the current advancements in this research area in terms of the different microfabrication technologies(photolithography,laser ablation,and 3D bioprinting)employed and the physiological relevance of the obtained models in mimicking the features of native intestinal tissue.A major thrust of the manuscript is also on highlighting the dynamic interplay between intestinal cells(both the stem cells and differentiated ones)and different biophysical,biochemical,and mechanobiological cues along with interaction with other cell types and intestinal microbiome,providing goals for the future developments in this sphere.The article also manifests an outlook toward the application of induced pluripotent stem cells in the context of intestinal tissue models.On a concluding note,challenges and prospects for clinical translation of 3D patterned intestinal tissue models have been discussed. | Tarun Agarwal Valentina Onesto Lallepak Lamboni Aafreen Ansari Tapas K.Maiti Pooyan Makvandi Massoud Vosough Guang Yang | 2021 | Bio-Design and Manufacturing2021，4，3： | 0 |
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