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| 1 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 2 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 3 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 4 | Multi-modality imaging of cardiac amyloidosis: Contemporary update显示文摘Cardiac amyloidosis is a heterogeneous and challenging diagnostic disease with poor prognosis that is now being altered by introduction of new therapies.Echocardiography remains the first-line imaging tool, and when disease is suspected on echocardiography, cardiac magnetic resonance imaging and nuclear imaging play critical roles in the non-invasive diagnosis and evaluation of cardiac amyloidosis. Advances in multi-modality cardiac imaging allowing earlier diagnosis and initiation of novel therapies have significantly improved the outcomes in these patients. Cardiac imaging also plays important roles in the risk stratification of patients presenting with cardiac amyloidosis. In the current review, we provide a clinical and imaging focused update, and importantly outline the imaging protocols, diagnostic and prognostic utility of multimodality cardiac imaging in the assessment of cardiac amyloidosis. | Tom Kai Ming Wang Ossama K Abou Hassan Wael Jaber Bo Xu | 2020 | World Journal of Radiology2020，12，6： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | Numerical calculation of flow and isotope separation for SF6 gas centrifuge显示文摘 | KAI T HASEGAWA K | 2000 | J Nucl Sci Technol2000，37，2： | 1 |
| 7 | Treatment for extrahepatic metastasis of hepatocellular carcinoma following suecessful hepatic resection 显示文摘 | Aramaki M Kawano K Kai T | 1999 | Hepato Gastroenterol1999，46，4： | 1 |
| 8 | Variation in CD4 T and CD8 T lymphocyte subpopulations in bo- vine mammary gland secretions during lactating and non-lactating periods显示文摘 | ASAI K KAI K RIKIISHI H | 1998 | Vet Immunol Imrnuno- patho1998，65，1： | 1 |
| 9 | Investigation of chitosan- phenolics systems as wood adhesives 显示文摘 | Svetlana P K Li Kai -chang | 2003 | Journal of Bioteehnology2003，102，： | 1 |
| 10 | Heterogenesis of prognosis in adult IgA nephropathy, especially with mild proteinuria or mild histological features显示文摘 | Usui J Yamagata K Kai H | | 0，，： | 1 |
| 11 | Aceumulation of coumarins in Arabidopsis thaliana显示文摘 | KAI K SHIMIZU B MIZUTANI M | 2006 | Phytochemistry2006，67，4： | 1 |
| 12 | Inhibition of the insulin-like growth factor 1 receptor pathway enhances the antitumor effect of cisplatin in human malignant mesothelioma cell lines显示文摘 | Kai K D'Costa S Sills RC | | 0，，1： | 1 |
| 13 | Coexistence of hypercholesterolemia and hypertension impairs adventitial vascularization显示文摘 | Kai H Kuwahara F Tokuda K | | 0，，2： | 1 |
| 14 | Accumulation of coumarins in Arabidopsis thaliana显示文摘 | KAI K SHIMIZU B MIZUTANI M | 2006 | Phytochemistry2006，67，4： | 1 |
| 15 | Mesenchymal stem cell-based prostacyclin synthase gene therapy for pulmonary hypertension rats显示文摘 | TAKEMIYA K KAI H YASUKAWA H | 2009 | Basic Res Cardio2009，105，3： | 1 |
| 16 | Heterogeneity of prognosis in aduh IgA nephropathy, especially with mild proteinuria or mild histological features 显示文摘 | Usui J Yamagata K Kai H | 2001 | Intern Med2001，40，8： | 1 |
| 17 | Subcutaneous emphysema along cutaneous striae after laparoscopic surgery: a unique complication显示文摘 | Nakajima K Kai Y Yasumasa K | 2006 | Surg Laparosc Endosc Percutan Tech2006，16，： | 1 |
| 18 | Does survey format influence self-disclosure on sensitive question items显示文摘 | Kays K Gathercoal K Buhrow W | | 0，，01： | 1 |
| 19 | Pressure-independent effects of angiotensin 显示文摘 | Tokuda K Kai H Kuwahara F | 2004 | Hypertension2004，43，2： | 1 |
| 20 | MMP14 gene polymorphisms in chronic obstructive pulmonary disease显示文摘 | Saitoh W Sakamoto T Hegab A E Nomura A Ishii Y Morishima Y Kai S Iizuka T Kiwamoto T Matsuno Y Massoud H H Massoud H M Hassanein K M Sekizawa K | 2006 | Int J Mol Med2006，17，6： | 1 |
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