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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Response surface analysis and sinulation as tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 3 | Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia显示文摘 | Berton D C Kalil A C Teixeira P J | 2014 | Cochrane Database Syst Rev2014，30，00： | 1 |
| 4 | Effects ofprolonged use of azithromycin in patients with cystic fibrosis : ameia-analysis 显示文摘 | FLORKSCU D F MURPHY P J KALIL A C | 2009 | Pulm Pharmacol Ther2009，22，6： | 1 |
| 5 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 6 | Response surface analysis and simulation as a tool for bioproeess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Pro- gress Biochemistry2000，35，6： | 1 |
| 7 | Rethinking the multiple roles of B cells in organ transplantation 显示文摘 | Coelho V Saitovitch D Kalil J | 2013 | Curt Opin Organ Transplant2013，18，1： | 1 |
| 8 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil J Maugeri F Rodrigues M I | 2000 | Process Biochem2000，35，： | 1 |
| 9 | Rheumatic heart disease : mediation by com- plex immune events显示文摘 | Guilherme L Khler KF Kalil J | 2011 | Adv Clin Chem2011，53，： | 1 |
| 10 | Rheumatic heart disease: molecules involved in valve tissue inflammation leading to the autoimmune process and anti-s, pyogenes vaccine 显示文摘 | GUILHERME L KALIL J | 2013 | Front Immunol2013，4，： | 1 |
| 11 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | Process Biochemistry2000，35，： | 1 |
| 12 | Meta-analysis:the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients显示文摘 | Kalil AC Levitsky J Lyden E | 2005 | Ann Intern Med2005，143，12： | 1 |
| 13 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | Proc Biochem2000，35，： | 1 |
| 14 | Rheumatic fever and rheumatic cellular mechanisms leading autoimmune disease显示文摘 | Guilherme L heart disease : reactivity and Kalil J | 2010 | J Clin Immunol2010，30，1： | 1 |
| 15 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 16 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 17 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | Process Biochemistry2000，35，6： | 1 |
| 18 | Meta-analysis:the efficacy of strategies to prevent organ disease by cytomegalovirus in solid organ transplant recipients显示文摘 | Kalil AC Levitsky J Lyden E | 2005 | Ann Intern Med2005，143，12： | 1 |
| 19 | Response surface analysis and simulation as a tool for bioprocess design and optimization 显示文摘 | KALIL S J MAUGERI F RODRIGUES M I | 2000 | process Biochemistry2000，35，6： | 1 |
| 20 | Response surface analysis and simulation as a tool for bioprocess design and optimization显示文摘 | Kalil S J Maugeri F Rodrigues M I | 2000 | J Process Biochem2000，35，： | 1 |
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