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| 1 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 2 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
| 3 | Antioxidant capacity, vi- tamin C, phenolics, and anthocyanins after fresh storage of small fruits显示文摘 | Kall W Forney CF Martin A et M | 1999 | J Agric Food Chem1999，47，11： | 1 |
| 4 | comparative scanning ,transmission and atomic force microscopy of the microtubular cytoskeleton in fenestrated liver endothelial cells 显示文摘 | Braet F Zanger DR Kalle W | 1996 | Scanning Microsc Suppl1996，10，： | 1 |
| 5 | High-resolution in situ hybridization using DNA halo preparations显示文摘 | Wiegant J Kalle W Mullenders L | 1992 | Hum Mol Genet1992，1，： | 1 |
| 6 | Protective effect of grape seed extracts on human lymphocytes: a preliminary study显示文摘 | Szeto Y T Lee K Y Kalle W | 2013 | Applied Physiology Nutrition and Metabolism2013，38，3： | 1 |
| 7 | Protective effect of grape seed extracts on human lymphocytes:a preliminary study显示文摘 | Szeto Y T Lee K Y Kalle W | 2013 | Applied Physiology Nutrition and Metabolism2013，38，3： | 1 |
| 8 | Hepatocyte targeted expression by integrase defec- tive lentiviral vectors induces antigen specific tolerance in mice with low genotoxic risk显示文摘 | Mdtrai J Cantore A Bartholomae C C Annoni A Wang W Acosta-Sanchez A Samara-Kuko E De Waele L Ma L Genovese P Damo M Arens A Goudy K Nichols T C yon Kalle C Chuah M K L Roncarolo M G Schmidt M Driessche T V Naldini L | 2011 | Hepatology2011，53，5： | 1 |
| 9 | High-resolution in situ hybridization using DNA halo preparations显示文摘 | Kalle W Mullenders L Brookes S Hoovers J M Dauwerse J G van Ommen G J Raap A K | 1992 | Human Mol Genet1992，1，： | 1 |
| 10 | Direct human DNA protection by Coriolus versicolor (Yunzhi) extract显示文摘 | Szeto Y T Lau P C Kalle W | 2013 | Pharmaceutical Biology2013，51，7： | 1 |
| 11 | High resolution in situ hybridization using DNA halo preparations显示文摘 | Kalle W Mullenders L Brookes S Hoovers J M N Dauwerse J G van Ommen GJ B Raap A K | 1992 | Human Molecular Genetics1992，，1： | 1 |
| 12 | High-resolution iin situ hybridization using DNA halo preparations 显示文摘 | Wiegant J Kalle W Mullenders L | 1992 | Human Molecular Genetics1992，1，： | 1 |
| 13 | Highresolution in situ hybridization using DNA halo preparations显示文摘 | WIEGANT J KALLE W MULLENDERS L | 1992 | Human Molecular Genetics1992，1，8： | 1 |
| 14 | High-resolution in situ hybridization using DNA halo preparatians显示文摘 | Wiegant J Kalle W Mullenders L | 1992 | Hum Mol Genet1992，1，8： | 1 |
| 15 | Reduced expression of APC and DCC gene protein in breast cancer显示文摘 | Ho K Y Kalle W H Lo T H | 1999 | Histopathology1999，35，3： | 1 |
| 16 | Effects of diabetes type 2 and metformin treatment in Swedish patients with colorectal cancer显示文摘The association between type 2 diabetes mellitus(DM)and colorectal cancer(CRC)has been thoroughly investigated and reports have demonstrated that the risk of CRC is increased in DM patients.The association between DM and the survival of patients with CRC is controversial.Evidence suggests that metformin with its anti-inflammatory effects is a protective factor against the development of CRC among DM patients and that metformin therapy is associated with a better prognosis in patients with DM.In our cohort,we did not find any associations between the presence of DM or metformin and cancer specific survival or any relation to plasma levels of a panel of 40 inflammatory factors and irisin.On the other hand,we identified that the insulin-like growth factor binding protein 7 single nucleotide polymorphism rs2041437 was associated with DM in CRC patients.The dominance of the T bearing genotypes in patients with DM was statistically significant(P=0.038),with an odds ratio of 1.66(95%confidence interval:1.03-2.69). | Jan Dimberg Levar Shamoun Kalle Landerholm Dick Wågsäter | 2022 | World Journal of Gastroenterology2022，28，19： | 0 |
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