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| 1 | Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait显示文摘Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic deficiency.This pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait assessment.Findings:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot study.Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual task.Clinical,and subjective assessments of gait,quality of life,and safety were also administered.The primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary outcome.The gait analysis protocol correlated well with clinical scales,but not with subjective assessments.DBS patients were more likely to increase gait velocity(p=0.033),and improved in other clinical assessments.Conclusions:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective measures.These findings can inform future trials in this population. | Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson | 2015 | Translational Neurodegeneration2015，4，1： | 3 |
| 2 | CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes显示文摘AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury models.METHODS:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TNF)-α-[D-Gal N/lipopolysaccharide(LPS)]induced apoptosis.Liver injury was assessed by measurement of serum transaminases and histological analysis.Apoptosis induction was quantified by cleaved PARP staining and Western blotting of activated caspases.Nuclear factor(NF)-κB,ERK,Akt and jun amino-terminal kinases signaling were assessed.Primary Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TNF-αand with the CD95-ligand Jo2.Cell viability was analyzed by MTT-assay.RESULTS:Livers of CYLD-/-mice showed increased anti-apoptotic NF-κB signaling.In both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis sensitivity.After D-Gal N/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,P<0.05)and aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,P<0.01).After Jo injection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,P<0.01)and lower AST(250 U/L vs 435 U/L,P<0.01)serumlevels compared to WT mice.In addition,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TNF-and CD95-receptor triggering,respectively.Inhibition of NF-κB activation by the inhibitor of NF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TNF-and CD95-receptor mediated cell death.CONCLUSION:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-κB dependent anti-apoptotic signaling. | Toni Urbanik Bruno Christian Koehler Laura Wolpert Christin Elbner Anna-Lena Scherr Thomas Longerich Nicole Kautz Stefan Welte Nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen | 2014 | World Journal of Gastroenterology2014，20，45： | 3 |
| 3 | Rapid and flexible segmentation of electron microscopy data using few-shot machine learning显示文摘Automatic segmentation of key microstructural features in atomic-scale electron microscope images is critical to improved understanding of structure–property relationships in many important materials and chemical systems.However,the present paradigm involves time-intensive manual analysis that is inherently biased,error-prone,and unable to accommodate the large volumes of data produced by modern instrumentation.While more automated approaches have been proposed,many are not robust to a high variety of data,and do not generalize well to diverse microstructural features and material systems.Here,we present a flexible,semi-supervised few-shot machine learning approach for segmentation of scanning transmission electron microscopy images of three oxide material systems:(1)epitaxial heterostructures of SrTiO_(3)/Ge,(2)La_(0.8)Sr_(0.2)FeO_(3) thin films,and(3)MoO_(3) nanoparticles.We demonstrate that the few-shot learning method is more robust against noise,more reconfigurable,and requires less data than conventional image analysis methods.This approach can enable rapid image classification and microstructural feature mapping needed for emerging high-throughput characterization and autonomous microscope platforms. | Sarah Akers Elizabeth Kautz Andrea Trevino-Gavito Matthew Olszta Bethany E.Matthews Le Wang Yingge Du Steven R.Spurgeon | 2021 | npj Computational Materials2021，，1： | 3 |
| 4 | Microbial activity in a sandy arable soil is governed by the fertilization regime显示文摘 | Timo Kautz Stephan Wirth Frank Ellmer | 2004 | European Journal of Soil Biology2004，，2： | 2 |
| 5 | Control of the molecular weight of hyperbranched polyglycerols 显示文摘 | Holger Kautz Alexander Sunder Holger Frey | 2001 | Macromolecular Symposia2001，163，1： | 2 |
| 6 | Stent migration necessitating surgical intervention显示文摘 | R. Diller N. Senninger G. Kautz D. Tübergen | 2003 | Surgical Endoscopy2003，，11： | 2 |
| 7 | Synthesis of oligonucleotide funetionalized magnetic nanoparticles and study on their in vitro cell uptake显示文摘 | Wagner K Kautz A Roder M | 2004 | Appl Organometal Chem2004，18，： | 1 |
| 8 | Review of transcranial direct current stimulation in poststroke recovery 显示文摘 | Feng WW Bowden MG Kautz S | 2013 | Top Stroke Rehabil2013，20，1： | 1 |
| 9 | ReferralWeb:combining social networks and collaborative filtering显示文摘 | KAUTZ H SELMAN B SHAH M | 1997 | Communications of the ACM1997，40，3： | 1 |
| 10 | Microbial activity in a sandy arable soil is governed by the fertilization regime显示文摘 | Timo Kautz Stephan Wirth Frank Ellmer | 2004 | European Journal of Soil Biology2004，40，： | 1 |
| 11 | Calibration by NMR for quantitative analysis:p-toluenesulfonic acid as a reference substance显示文摘 | SHAO G KAUTZ R PENG S | | 0，，1： | 1 |
| 12 | Spatial characterization of bark beetle infestations by a multidate synergy of SPOT and Landsat imagery显示文摘 | Latifi H Schumann B Kautz M | 2014 | Environmental Monitoring and Assessment2014，186，1： | 1 |
| 13 | Evaluation of an in- dwelling ruminal probe methodology and effect of grain level on diurnal pH variation in dairy cattle 显示文摘 | NOCEK J E ALLMAN J G KAUTZ W P | 2002 | Journal of Dairy Science2002，85，2： | 1 |
| 14 | Changes in life expectancy in the United States due to declines in mortality, 1968-1975 显示文摘 | Tsai SP Lee ES Kautz JA | 1982 | Am J Epidemiol1982，116，： | 1 |
| 15 | Foot placement in a body reference frame during walking and its relationship to hemiparetic walking performance显示文摘 | Balasubramanian CK Neptune RR Kautz SA | 2010 | Clin Biomech (Bristol Avon)2010，25，5： | 1 |
| 16 | Image-based reconstruction of spatial appearance and geometric detail显示文摘 | Lensch H P A Kautz J Goesele M | | 0，，02： | 1 |
| 17 | Recommendations for the Management of Hepatitis C Virus Infection Among People Who Inject Drugs显示文摘 | Geert Robaeys Jason Grebely Stefan Mauss Philip Bruggmann Joseph Moussalli Andrea De Gottardi Tracy Swan Amber Arain Achim Kautz Heino St?ver Heiner Wedemeyer Martin Schaefer Lynn Taylor Markus Backmund Olav Dalgard Maria Prins Gregory J. Dore | 2013 | Clinical Infectious Diseases . 2013 (supp)2013，，： | 1 |
| 18 | Direct-fed microbial supplementation on the performance of dairy cattle during the transition period 显示文摘 | Nocek J E Kautz W P Leedle J A Z | 2003 | J Dairy Sci2003，86，： | 1 |
| 19 | Enhancing health promotion during reha- / bilitation through information-giving,partnership-braiding,and teach-back显示文摘 | Hyde YM Kautz DD | 2014 | Rehabil Nurs2014，39，4： | 1 |
| 20 | Evaluation of an indwelling ruminal probe methodology and effect of grain level on diurnal pH variation in dairy cattle显示文摘 | NOCEK J E ALLMAN J G KAUTZ W P | 2002 | Journal of Dairy Science2002，85，： | 1 |
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