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| 1 | Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic显示文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. | Shashi Kant Singh Saurabh K Sinha SK Prasad R Kumar Bhawani S Bithu S Sadish Kumar P Singh | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 4 |
| 2 | Actinomycin D adsorbed on polymethylcyanoacrylate nanoparticles:increased efficiency against an ex-perimental tumor显示文摘 | Brasseur P Couvreur P’Kante B et a1 | | 0，，： | 1 |
| 3 | Stress response suppressorl and stress response suppressor2, two DEAD-box RNA helicases that attenuate A rabidopsis responses to multiple abiotic stresses显示文摘 | Kant P Kant S Gordon M | 2007 | Plant Physiol2007，145，3： | 1 |
| 4 | The application ofbiotechnology to orchids显示文摘 | Hossain M M Kant R Van P T Winarto B Zeng S J Teixeira da Silva J A | | 0，，02： | 1 |
| 5 | Nanopore gradients on porous aluminum oxide generated by nonuniform anodiza- tion of aluminum 显示文摘 | KANT K LOW S P MARSHAL A | 2010 | ACS Applied Materials & Interfaces2010，2，12： | 1 |
| 6 | STRS1 and STRS2, two DEAD-box RNA helicases that attenuate Arabidopsis responses to multiple abiotic stresses 显示文摘 | KANT P KANT S GORDON M | 2007 | Plant Physiology2007，145，3： | 1 |
| 7 | Rationalization in Garages in the Netherlands and Its Effects on Occupational Health显示文摘 | HOUBEN G J DIEDERIKS J P M KANT Y | 1990 | Work & Stress1990，4，2： | 1 |
| 8 | Sustainable valorization of plastic wastes for energy with environmental safety via high-temperature pyrolysis (HTP) and high-temperature steam gasification (HTSG)显示文摘 | KANT ARELIS E DONAJ P YANG W | | 0，，1： | 1 |
| 9 | Structure,microstructure and physical properties of ZnO based materials in various forms:Bulk,thin film and nano显示文摘 | Singh S Thiyagarajan P Kant K M | 2007 | J Phys D:Appl Phys2007，40，20： | 1 |
| 10 | Excess body weight and obesity-the link with gastrointestinal and hepatobiliary cancer显示文摘 | Kant P Hull MA | 2011 | Nat Rev Gastroenterol Hepatol2011，8，4： | 1 |
| 11 | Speiscret, oral and parenteral administration of insulin associated to hydrolyzable nanoparticles 显示文摘 | Couvreur P Lenaerts V Kante B | 1980 | Acta Pharm Tech1980，26，： | 1 |
| 12 | Excess body weight and obesity-the link with gastrointestinal and hepatobiliary cancer显示文摘 | Kant P Hull M A | 2011 | Nat Rev Gastroebterol Hepatol2011，8，4： | 1 |
| 13 | Implementation of a macro model to predict seismic response of RC structure walls 显示文摘 | Fischinger M Isakovic T Kante P | 2004 | Computers and Concrete2004，1，2： | 1 |
| 14 | Basic features of bovine spermatogonial culture and effects of glial cell line- derived neurotrophic factor 显示文摘 | Aponte P M Soda T Van de Kant H J G et ol | 2006 | Theriogenology2006，65，9： | 1 |
| 15 | Strategies for avoiding the pitfalls of performance contracting显示文摘 | Kant P A | 1999 | Public Productivity and Management Review1999，，4： | 1 |
| 16 | Effects of increased Peritoneal clearances on mortality rates in peritoneal dialysis:a DEMEX,a prospective,ra ndomized,controlled trial显示文摘 | Ramon P Kante A Edward V | 2002 | J Am SocNephrol2002，13，： | 1 |
| 17 | Toxicity ofpolyalkylcyanoacrylate nanoparticles Ⅰ: free nanoparticles显示文摘 | Kante B Couvreur P Dubois K | 1982 | J Pharm Sci1982，71，7： | 1 |
| 18 | Behaviour of CFPC strengthed reinforced concrete beams with varying degrees of strengthening显示文摘 | Ramana VPV Kant T Morton S E Dutta P K Mukherjee A Desai Y M | 2000 | J Comp Part B2000，31，： | 1 |
| 19 | Growth, differentiation, and migration of osteoblasts on transparent Ni doped TiO2 thin films deposited on borosilicate glass显示文摘 | Dhayal M Kapoor R Sistla P G Kant C Pandey R R Govind | 2012 | J Biomed Mater Res A2012，100，： | 1 |
| 20 | Behavior of CFRPC strengthened reinforced concrete beams with varying degrees of strengthening显示文摘 | V P V Ramana T Kant | 2000 | Composites: Part B2000，，31： | 1 |
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