|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 2 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 3 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 4 | Using the Balanced Scorecard as a Strategic Management System显示文摘 | Kaplan R S & Norton D P | 1996 | Harvard Business Review1996，，： | 1 |
| 5 | Chronic fatigue syndrome; H working case definition 显示文摘 | Holmes G P Kaplan J E Gantz N M | 1988 | Ann InternMed1988，108，： | 1 |
| 6 | Mantle helium in Sacramento basin natural gas wells显示文摘 | Poreda R J Jenden P D Kaplan I R | 1986 | Geochim Cosmochim Acta1986，50，： | 1 |
| 7 | Venture capitalists as principals: contracting, screening and monitoring显示文摘 | Stromberg P | 2001 | American Economic Review Papers and Proceedings2001，91，： | 1 |
| 8 | Transforming the balanced scorecard from performance measurement to strategic management显示文摘 | Norton David P | 2001 | Harvard Business Review2001，15，2： | 1 |
| 9 | Glutaric aciduria typell:review of thcphenotype and report of an unusual glomerulopathy显示文摘 | Wilson GN Chadarcvian JP Kaplan P | 1989 | Am J Med Gener1989，32，2： | 1 |
| 10 | Financial contracting theo- ry meets the real world: An empirical analysis of ven- ture capital contracts显示文摘 | Kaplan S N Stromberg p | 2003 | Review of Economic Studies2003，70，3： | 1 |
| 11 | Liver transplantation is not curative for methylmalonic acidopathy caused by methyl- malonyl-CoA mutase deficiency 显示文摘 | Kaplan P Ficicioglu C Mazur AT | 2006 | Mol Genet Metal)2006，88，4： | 1 |
| 12 | A Study of Prediction techniques for Aircraft Carrier Motion at Sea 显示文摘 | P Kaplan | 1969 | Journal of Iiydranautics1969，3，3： | 1 |
| 13 | The balanced scorecardmeastues that drive performance 显示文摘 | NORTON D P | 1992 | Harvand Busirness Review1992，，70： | 1 |
| 14 | Mantle helium in Sacramento basin natural gas wells显示文摘 | Poreda R J Jenden P D Kaplan E R | 1986 | Geochimica et Cosmochimica Acta1986，65，5： | 1 |
| 15 | Link the Balanced Scorecard to Strategy 显示文摘 | Kaplan R S Norton D P | 1996 | California Management Review1996，39，1： | 1 |
| 16 | Local intramural delivery of heparin during primary angioplasty for acute myocardial infarction:results of the local PAMI pilot study显示文摘 | Esente P Kaplan AV Ford JK | 1999 | Cath Cardiovasc Interv1999，47，： | 1 |
| 17 | The balanced scorecard measurement that drive performance显示文摘 | Kaplan R S Norton D P | 1992 | Harvard Business Review1992，70，1： | 1 |
| 18 | Nonparametric estimation from incomplete observations显示文摘 | Kaplan E L Meier P | 1958 | Journal of the American Statistical Association1958，53，3： | 1 |
| 19 | Nonparametric estimation from incomplete observations显示文摘 | KAPLAN E L MEIER P | 1958 | Am Stat Assoc J1958，53，282： | 1 |
| 20 | Financial contract- ing theory meets the real world: an empirical analysis of venture capital contracts显示文摘 | Kaplan S N S tr 5mberg P | 2003 | Review of Economic Stud-ies 70(2): 281-3152003，2003，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员