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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Evolution of microstructure and mechanical properties during annealing of cold-rolled AA8011 alloy显示文摘 | Roy R K Kar S Das S | 2009 | J Alloys Compd2009，468，12： | 1 |
| 3 | Slurry infitrated fiber concrete (SIFCON)显示文摘 | Lan kar D R | 1984 | Concrete International1984，6，12： | 1 |
| 4 | Nonlinear dynamics of a pipe conveying pulsating fluid with combination, principal parametric and internal resonances 显示文摘 | Panda L N Kar R C | 2008 | Journal of Sound and Vibration2008，309，35： | 1 |
| 5 | Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2YI and P2Y12 gene pol- ymorphisms显示文摘 | KAR R MEENA A YADAV B K | 2013 | Platelets2013，24，4： | 1 |
| 6 | Earthquake hydrodynamic forces on arch dams 显示文摘 | Permumalswami P R Kar L | 1973 | Journal of the Engineering Mechanics Division ASCE1973，99，5： | 1 |
| 7 | Relativistically correct hole-boring and ion acceleration by circularly polarized laser pulses显示文摘 | A P L Robinson P Gibbon M Zepf S Kar R G Evans C Bellei | 2009 | Plasma Physics and Controlled Fusion2009，，2： | 1 |
| 8 | Cross - entropy meas- ure of uncertain variables 显示文摘 | CHEN X W KAR S DAN A R | 2012 | Information Sciences2012，，201： | 1 |
| 9 | Vasopressin receptor antagonist in the treatment of the syndrome of inappropriate antidiuretic hormone in general hospital practice显示文摘 | Rajendran R Grossman AB Kar P | 2012 | Endocr J2012，59，： | 1 |
| 10 | Gap junctions and hemichannels in signal transmission,function and development of bone显示文摘 | Batra N Kar R Jiang JX | 2012 | Biochim Biophys Acta2012，1818，8： | 1 |
| 11 | Rotatory vibration of sphere of higher order viscoelastic solid显示文摘 | Sengupta P R De N Kar M | 1994 | Internat J Math Math Sci1994，17，4： | 1 |
| 12 | Pseudo Chediak-Higashianomaly in acute myelomonocytic leukemia 显示文摘 | Rao S Kar R Saxena R | 2009 | Indian J Pathol Microbiol2009，52，2： | 1 |
| 13 | Extraction of molybdenum from spent catalyst by salt-roasting 显示文摘 | Kar B B Murthy B V R Misra V N | 2005 | In- ternational Journal of Mineral Processing2005，76，3： | 1 |
| 14 | Studies on reaction mechanism of bioleaching of manganese ore显示文摘 | Acharya C Kar R N Sukla L B | 2003 | Minerals Engineering2003，16，10： | 1 |
| 15 | Electrical,mechanical,and thermal properties of exfoliated graphite/phenolic resin composite bipolar plate for polymer electrolyte membrane fuel cell显示文摘 | Sykam N Gautam R K Kar K K | 2015 | Polymer Engineering&Science2015，55，4： | 1 |
| 16 | Fault detection in a multistage gearbox by demodulation of motor current waveform显示文摘 | Mohanty A R Kar C | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 17 | Laser direct write of conducting and insulating tracks in silicon carbide 显示文摘 | SENGUPTA D K QUICK N R KAR A | 2000 | Materials Research Society Symposium-Proceedings2000，624，： | 1 |
| 18 | Role of Apoptotic Regulators in Human Epithelial Ovarian Cancer显示文摘 | Kar R Sen S Singh A | 2007 | Cancer Biol Ther2007，6，7： | 1 |
| 19 | Stimulation of protein kinase C modulates insulin-like growth factor-l-induced akt activation in PC12 cells 显示文摘 | Zheng W H Kar S Quirion R | 2000 | J Biol Chem2000，275，13： | 1 |
| 20 | Studies on Reaction Mech- anism of Bioleaching of Manganese Ore显示文摘 | Acharya C Kar R N Sukla L B | 2003 | Minerals Engi neering2003，16，10： | 1 |
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