|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 2 | Effects of different tunnel face advance excavation on the settlement by FEM 显示文摘 | Karakus M Fowell R J | 2003 | Tunnelling and Underground Space Technology2003，18，5： | 1 |
| 3 | Direct expressions for linearization of shear strength envelopes given by the Generalized Hoek-Brown criterion using genetic programming显示文摘 | Shen J Karakus M Xu C | 2012 | Computers and Geotechnics2012，44，： | 1 |
| 4 | MgO refractories for glass tank regenerators 显示文摘 | Velez M Karakus M Headrick L W | 2002 | American Ceramic Society Bulletin2002，81，10： | 1 |
| 5 | Appraising the methods accounting for 3D tunneling effects in 2D plane strain FE analysis显示文摘 | Karakus M | 2007 | Tunneling and Underground Space Technology2007，7，21： | 1 |
| 6 | Back analysis for tunnelling induced ground movements and stress redistribution显示文摘 | Karakus M Fowell R J | | 0，，： | 1 |
| 7 | Tramadol versus meperidine in the treatment of shivering during spinal anaesthesia显示文摘 | Kaya M Sariyildiz O Karakus D | 2003 | Eur J Anaesthesiol2003，20，4： | 1 |
| 8 | Effects of different tunnel face advance excavation on the settlement by FEM显示文摘 | Karakus M Fowell R J | | 0，，： | 1 |
| 9 | Comparison of the effects of two legal blood alcohol limits: the presence of alcohol in traffic accidents according to category of drlver in izmir, Turkey显示文摘 | Karakus A Idiz N Dalgic M | 2015 | Trahtlc lnjuryPrevention2015，16，5： | 1 |
| 10 | Effects of leptin and leptin receptor gene polymorphisms on lung cancer 显示文摘 | Unsal M Kara N Karakus N | 2014 | Tumour Biol2014，35，10： | 1 |
| 11 | The forensic deaths caused by pesticide poisoning between the years 2006 and2009 in Izmir,Turkey显示文摘 | IDIZ N KARAKUS A DALGIC M | 2012 | J Forensic Sci2012，57，4： | 1 |
| 12 | Bandomized double-blind comparison of simelbicone with cisapride in functional dysprpia 显示文摘 | Hollaoo G Karakue M | 1999 | Alimebl Pharmacol Tber1999，13，11： | 1 |
| 13 | Effects of leptin and leptin re- ceptor gene polymorphisms on lung cancer 显示文摘 | Unsal M Kara N Karakus N | 2014 | Tumour Biol2014，17，4： | 1 |
| 14 | Back analysis for tunneling induced ground movements and stress redistribution显示文摘 | KARAKUS M FOWELL R J | 2005 | Tunnelling and Underground Space Technology2005，20，6： | 1 |
| 15 | Determinants of health expenditure growth of the OECD countries: Jacknife resampling plan estimates显示文摘 | OKUNADE A A KARAKUS M C OKEKE C | 2004 | Health Care Management Science2004，7，： | 1 |
| 16 | The effects of 1713- estradiol plus drospirenone on anthropometric and biochemical measures of adiposity in menopausal women显示文摘 | Karakus M Gelisgen R Topcuoglu A | 2012 | Arch Gynecol Obstet2012，286，5： | 1 |
| 17 | Back Analysis for Tunnelling Induced Ground Movements and Stress Redistribution 显示文摘 | Karakus M Fowell R J | 2005 | Tunnelling and Underground Space Technology2005，20，6： | 1 |
| 18 | An investigation on the inhibition effects of some new dithiophosphonic acid monoesthers on the corrosion of thesteel in 1M HCl medium显示文摘 | Ahin M S Bilgic S | 2005 | Mater Chem Phys2005，92，： | 1 |
| 19 | Appraising the Methods Accounting for 3D Tunnelling Effects in 2D Plane Strain FE Analysis 显示文摘 | Karakus M | 2007 | Tunnelling and Underground Space Technology2007，22，1： | 1 |
| 20 | Effects of different tunnel face advance excavation on the settlement by FEM 显示文摘 | KARAKUS M | 2003 | Tunnelling and Underground Space Technology2003，，18： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员