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| 1 | 生精障碍的遗传因素显示文摘大概10%-15%的夫妇患有不孕不育,其中,男性因素导致的不育约占一半。部分是由男方的生精障碍导致的,但其根本原因,包括遗传性变异,仍知之甚少。迄今为止,男性不育症诊断中使用的唯一基因测试的目的是检测是否存在Y染色体长臂的微缺失或者染色体异常。各种其他单基因和多基因缺陷也己被提出与男性生育能力相关。但其致病作用仍有待验证。最近,全基因组技术和小鼠模型的大规模分析方面所取得的巨大进步可能有助于这方面的研究。利用基因敲除小鼠模型,至少有388个基因与小鼠生精相关的基因被发现了。但当前的主要问题在于如何把这些研究成果从小鼠转移应用到人类。 | Annelien Massart Willy Lissens Herman Tournaye Katrien Stouffs | 2012 | Asian Journal of Andrology2012，14，1： | 36 |
| 2 | A Single Active Trehalose-6-P Synthase (TPS) and a Family of Putative Regulatory TPS-Like Proteins in Arabidopsis显示文摘更高的植物典型地不在大数量生产 trehalose,但是他们的染色体序列揭示通常认为的 trehalose 新陈代谢酶的大家庭。在植物生长和开发的一个重要规章的角色也为新陈代谢的中间的 trehalose-6-P (T6P ) 正在出现。这里,我们在场 Arabidopsis trehalose 新陈代谢上的更改和为进一步详细的分析的一个资源。另外,我们提供 Arabidopsis 靠着可能在活跃地种纸巾完成特定的规章的功能的催化地不活跃的象 TPS 一样蛋白质的一个家庭编码单个 trehalose-6-P synthase (TPS ) 的证据。 | Lies Vandesteene Matthew Ramon Katrien Le Roy Patrick Van Dijck Filip Rolland | 2010 | Molecular Plant2010，3，2： | 22 |
| 3 | Structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis显示文摘Nowadays, liver metastasis remains difficult to cure. When tumor cells escape and arrive in the liver sinusoids, they encounter the local defense mechanism specific to the liver. The sinusoidal cells have been widely described in physiologic conditions and in relation to metastasis during the past 30 years. This paper provides an 'overview' of how these cells function in health and in diseases such as liver metastasis. | Katrien Vekemans Filip Braet | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 4 | Spatial H202 Signaling Specificity: H202 from Chloroplasts and Peroxisomes Modulates the Plant Transcriptome Differentially显示文摘 | Nasser Sewelam Nils Jaspert Katrien Van Der Kelen Vanesa B. Tognetti Jessica Schmitz Henning Frerigmann Elia Stahl Frank Van Breusegem Veronica G. Maurino | 2014 | Molecular Plant2014，7，7： | 4 |
| 5 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
| 6 | European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms显示文摘The BCR/ABL fusion gene or the Ph^1-chromosome in the t(9;22)(q34;q11)exerts a high tyrokinase acticity,which is the cause of chronic myeloid leukemia(CML).The1990 Hannover Bone Marrow Classification separated CML from the myeloproliferative disorders essential thrombocythemia(ET),polycythemia vera(PV)and chronic megakaryocytic granulocytic myeloproliferation(CMGM).The 2006-2008 European Clinical Molecular and Pathological(ECMP)criteria discovered 3variants of thrombocythemia:ET with features of PV(prodromal PV),'true'ET and ET associated with CMGM.The 2008 World Health Organization(WHO)-ECMP and 2014 WHO-CMP classifications defined three phenotypes of JAK2^(V617F)mutated ET:normocellular ET(WHO-ET),hypercelluar ET due to increased erythropoiesis(prodromal PV)and ET with hypercellular megakaryocytic-granulocytic myeloproliferation.The JAK2^(V617F)mutation load in heterozygous WHO-ET is low and associated with normal life expectance.The hetero/homozygous JAK2^(V617F)mutation load in PV and myelofibrosis is related to myeloproliferative neoplasm(MPN)disease burden in terms of symptomaticsplenomegaly,constitutional symptoms,bone marrow hypercellularity and myelofibrosis.JAK2 exon 12mutated MPN presents as idiopathic eryhrocythemia and early stage PV.According to 2014 WHO-CMP criteria JAK2 wild type MPL^(515)mutated ET is the second distinct thrombocythemia featured by clustered giant megakaryocytes with hyperlobulated stag-horn-like nuclei,in a normocellular bone marrow consistent with the diagnosis of'true'ET.JAK2/MPL wild type,calreticulin mutated hypercellular ET appears to be the third distinct thrombocythemia characterized by clustered larged immature dysmorphic megakaryocytes and bulky(bulbous)hyperchromatic nuclei consistent with CMGM or primary megakaryocytic granulocytic myeloproliferation. | Jan Jacques Michiels Fransje Valster Jenne Wielenga Katrien Schelfout Hendrik De Raeve | 2015 | World Journal of Hematology2015，4，3： | 3 |
| 7 | Nondestructive measurement of fruit and vegetable quality by means of NIR spectroscopy: A review显示文摘 | Bart M. Nicola? Katrien Beullens Els Bobelyn Ann Peirs Wouter Saeys Karen I. Theron Jeroen Lammertyn | 2007 | Postharvest Biology and Technology2007，，2： | 3 |
| 8 | Regional differences in lung radiosensitivity after radiotherapy for non–small-cell lung cancer显示文摘 | Yvette Seppenwoolde Katrien De Jaeger Liesbeth J. Boersma José S.A. Belderbos Joos V. Lebesque | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 2 |
| 9 | Chloride binding of cement-based materials subjected to external chloride environment – A review显示文摘 | Qiang Yuan Caijun Shi Geert De Schutter Katrien Audenaert Dehua Deng | 2008 | Construction and Building Materials2008，，1： | 2 |
| 10 | Acute Radiation Effects on Cardiac Function Detected by Strain Rate Imaging in Breast Cancer Patients显示文摘 | Katrien Erven Ruxandra Jurcut Caroline Weltens Sorin Giusca Joris Ector Hans Wildiers Walter Van den Bogaert Jens-Uwe Voigt | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 2 |
| 11 | Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis显示文摘 | Sonia O Labeau Katrien Van de Vyver Nele Brusselaers Dirk Vogelaers Stijn I Blot | 2011 | The Lancet Infectious Diseases2011，，11： | 1 |
| 12 | Students ap proaches to learnmg and assessment preferences in a portfolio-based learning environment 显示文摘 | Marlies Baeten Filip Dochy & Katrien Struyven | 2008 | Journal Instructional Science2008，，36： | 1 |
| 13 | Invasive aspergillosis in the Inten-sive Care Unit显示文摘 | Wouter M Katrien L Johan M | 2007 | Clinical Infectious Diseases 120072007，，： | 1 |
| 14 | Multimedia learning in social sciences: Limitations of external graphical representations 显示文摘 | De Westelinck Katrien Valcke Martin De Craene Brigitte & Kirschner Paul | 2005 | Computers in Human Behavior2005，21，4： | 1 |
| 15 | The promoter of the plant defensin gene PDF1.2 from Arabidopsis is systemically activated by fungal pathogens and responds to methyl jasmonate but not to salicylic acid显示文摘 | John M. Manners Iris A.M.A. Penninckx Katrien Vermaere Kemal Kazan Rebecca L. Brown Andrew Morgan Donald J. Maclean Mark D. Curtis Bruno P.A. Cammue Willem F. Broekaert | 1998 | Plant Molecular Biology1998，，6： | 1 |
| 16 | Lognormal Mixed Models for Reported Claims Re- serves 显示文摘 | Katrien Antonio | 2006 | North American Actuarial Journal2006，10，1： | 1 |
| 17 | Synthesis of modifi ed polyfether ether ketone) polymer for the preparation of ultra fi ltration and nanofiltration membranes via phase inversion显示文摘 | Katrien H Marianne V Guy K | 2013 | J Membr Sci2013，447，： | 1 |
| 18 | Molecular Cloning of the Human p120 ctn Catenin Gene (CTNND1): Expression of Multiple Alternatively Spliced Isoforms显示文摘 | Annick Keirsebilck Stefan Bonné Katrien Staes Jolanda van Hengel Friedel Nollet Albert Reynolds Frans van Roy | 1998 | Genomics1998，，2： | 1 |
| 19 | Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat显示文摘 | Nigel E.J. Appleford Daniel J. Evans John R. Lenton Paul Gaskin Stephen J. Croker Katrien M. Devos Andrew L. Phillips Peter Hedden | 2006 | Planta2006，，3： | 1 |
| 20 | Influence of Cracks on the Service Life of Concrete Structures in a Marine Environment显示文摘 | Audenaert Katrien Marsavina Liviu De Schutter Geert | 2009 | Key Engineering Materials2009，，399： | 1 |
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