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| 1 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 2 | Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis显示文摘 | DI BACCO A KEESHAN K MCKENNA S L | 2000 | Oncologist2000，5，： | 1 |
| 3 | Tribbles in acute leukemia显示文摘 | Liang KL Rishi L Keeshan K | 2013 | Blood2013，121，21： | 1 |
| 4 | Tribbles Homolog 2 inactivates C/EBPα and cause acute myelogenous leukemia显示文摘 | Keeshan K He B Wouters O | 2006 | Cancer Cell2006，10，5： | 1 |
| 5 | High bcr-abl expression prevents the translocation of Bax and bad to the mitochondrion显示文摘 | Keeshan K Cotter TG McKenna SL | 2002 | Leukemia2002，16，9： | 1 |
| 6 | The functionally diverse roles of tribbles显示文摘 | Lohan F Keeshan K | 2013 | Biochem Soc Trans2013，41，4： | 1 |
| 7 | Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently sup pressed by C/EBPalpha显示文摘 | Ferrari-Amorotti G Keeshan K Zattoni M | 2006 | Blood2006，108，： | 1 |
| 8 | Differential ability of Trib- bles family members to promote degradation of C/EBPalpha and in- duce acute myelogenous leukemia显示文摘 | Dedhia PH Keeshan K Uljon S | 2010 | Blood2010，116，8： | 1 |
| 9 | Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis显示文摘 | Dibacco A Keeshan K McKenna S L | 2000 | Oneologist2000，5，5： | 1 |
| 10 | The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression 显示文摘 | Chen Y X Yan J Keeshan K | 2006 | Proe Natl Acad Sci2006，103，： | 1 |
| 11 | Elevated bcr/abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype显示文摘 | Keeshan K Mills K I Coner T G | 2001 | Leukemia2001，15，： | 1 |
| 12 | Transcription activationfunction of C/EBPa is required for induction of granulocytedifferentiation 显示文摘 | Keeshan K Santilli G Corradini F | 2003 | Blood2003，102，： | 1 |
| 13 | Tribbles homolog 2 inactivates C/EBP alpha and causes acute myelogenous leukemia 显示文摘 | KEESHAN K HE Y WOUTERS B J | 2006 | Cancer Cell2006，10，5： | 1 |
| 14 | The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression显示文摘 | Chen YN Yan J Keeshan K | 2006 | Proc Natl Acad Sci USA2006，103，4： | 1 |
| 15 | Tribbles homolog 2 inactivates C/EBP alpha and causes acute myelogenous leukemia显示文摘 | KEESHAN K HE Y WOUTERS B J | 2006 | Cancer Cell2006，10，5： | 1 |
| 16 | Leukemogenesis induced by wild-type and STI571-resistant bcr/abl is potently suppressed by C/EBP alpha显示文摘 | FERRARI-AMOROTTI G KEESHAN K ZATTONI M | 2006 | Blood2006，108，4： | 1 |
| 17 | Differential ability of tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia显示文摘 | Dedhia P H Keeshan K Sacha U J | | 0，，08： | 1 |
| 18 | Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acutemyelogenous leukemia显示文摘 | Dedhia PH Keeshan K Uljon S | 2010 | Blood2010，116，： | 1 |
| 19 | Molecular abnormalities in chronic myeloid leukemia:deregulation of cell growth and apoptosis显示文摘 | Di Bacco A Keeshan K McKenna SL | 2000 | Oncologist2000，5，5： | 1 |
| 20 | Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPα显示文摘 | Ferrari-Amorotti G Keeshan K Zattoni M | 2006 | Blood2006，108，4： | 1 |
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