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| 1 | Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis显示文摘Background:Liver regeneration following partial hepatectomy(PHx)is a complicated process involving multiple organs and several types of signaling networks.The bile acid-activated metabolic pathways occupy an auxiliary yet important chapter in the entire biochemical story.PHx is characterized by rapid but transient bile acid overload in the liver,which constitutes the first wave of proliferative signaling in the remnant hepatocytes.Bile acids trigger hepatocyte proliferation through activation of several nuclear receptors.Following biliary passage into the intestines,enterocytes reabsorb the bile acids,which results in the activation of farnesoid X receptor(FXR),the consequent excretion of fibroblast growth factor(FGF)19/FGF15,and its release into the enterohepatic circulation.FGF19/FGF15 subsequently binds to its cognate receptor,fibroblast growth factor receptor 4(FGFR4)complexed withβ-klotho,on the hepatocyte membrane,which initiates the second wave of proliferative signaling.Because some bile acids are toxic,the remnant hepatocytes must resolve the potentially detrimental state of bile acid excess.Therefore,the hepatocytes orchestrate a bile acid detoxification and elimination response as a protective mechanism in concurrence with the proliferative signaling.The response in part results in the excretion of(biotransformed)bile acids into the canalicular system,causing the bile acids to end up in the intestines.Relevance for patients:Recently,FXR agonists have been shown to promote regeneration via the gut-liver axis.This type of pharmacological intervention may prove beneficial for patients with hepatobiliary tumors undergoing PHx.In light of these developments,the review provides an in-depth account of the pathways that underlie post-PHx liver regeneration in the context of bile acid homeostasis in the liver and the gut-liver signaling axis. | Lianne de Haan Sarah Jvan der Lely Anne-Loes K.Warps Quincy Hofsink Pim B.Olthof Mark J.de Keijzer Daniel A.Lionarons Lionel Mendes-Dias Bote G.Bruinsma Korkut Uygun Hartmut Jaeschke Geoffrey C.Farrell Narci Teoh Rowan Fvan Golen Tiangang Li Michal Heger | 2018 | Journal of Clinical & Translational Research2018，4，1： | 2 |
| 2 | Superchiral near fields detect virus structure显示文摘Optical spectroscopy can be used to quickly characterise the structural properties of individual molecules.However,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component molecules.This insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical objects.This limits potential routes to rapid high-throughput portable detection appropriate for point-of-care diagnostics.Here,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus capsids.Thus,they can detect both the presence and relative orientation of a bound virus capsid.To illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum. | Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew J.Love Joel J.Milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian J.Lapthorn Malcolm Kadodwala | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 3 | A seed shape mutant of Arabidopsis that is affected in integument development显示文摘 | Leon-Kloosterziel K M Keijzer C J Koornneef M | 1994 | Plant Cell1994，，6： | 1 |
| 4 | Light distribution in a port wine stain model containing multiple cylindrical and curves blood vessels 显示文摘 | Lucassen GW Verkruysse W Keijzer M | 1996 | Lasers Surg Med1996，18，： | 1 |
| 5 | Differences in the population structure of invasive Streptococcus suis strains isolated from pigs and from humans in the Netherlands显示文摘 | Schultsz C Jansen E Keijzers W | 2012 | PLoS One2012，7，33： | 1 |
| 6 | Bcl-2 and Bax proteins are present in interphase nuclei of mammalian cell显示文摘 | Hoetelmans R Van slooten H J Keijzer R | 2000 | Cell Death Differ2000，7，4： | 1 |
| 7 | A new method to detect apoptosis in paraffinsection:in situ end labeling of fragmented DNA显示文摘 | Wijsman JH Jonker PR Keijzer R | 1993 | J Histochem Cytochem1993，41，： | 1 |
| 8 | Caffeine can decrease insulin sensitivity in humans 显示文摘 | Keijzers GB De Galan BE Tack CJ | 2002 | Diabetes Care2002，25，2： | 1 |
| 9 | Morphological changes in tuber during dormancy and initial sprout growth of seed potatoes 显示文摘 | Van Ittersum M K Aben F B Keijzer C J | 1992 | Potato Research1992，35，： | 1 |
| 10 | 显示文摘 | Papageorgopoulos D C Keijzer M de Bruijin F A | 2002 | Electro- chim Acta2002，48，2： | 1 |
| 11 | The inclusion of Mo, Nb and Ta in Pt and PtRu carbon supported 3 electrocatalysts in the quest for improved CO tolerant PEMFC anodes显示文摘 | Papageorgopoulos D C Keijzer M de Bruijn F A | 2002 | Electrochimica Acta2002，48，2： | 1 |
| 12 | A novel approach to multi-criteria inverse planning for IMRT 显示文摘 | BREEDVELD S STORCHI P R KEIJZER M A | 2007 | PhysMedBiol2007，52，20： | 1 |
| 13 | DEC2135 + dendritic cell-targeted ldetogeafic vaccination promotes immune tolerance in experimental autoimmune arthritis 显示文摘 | Spiering R Margty B Keijzer C | 2015 | J Immunol2015，194，10： | 1 |
| 14 | Flow cytometry and the urine laboratory:field evaluation of the Sysmex UF-100TM显示文摘 | De Keijzer MH Brandts RW | 1997 | Sysmex J Int1997，7，2： | 1 |
| 15 | A new method to detect apoptosis in paraffin section显示文摘 | Jonker PR Keijzer R | 1993 | J Histochem Cytochem1993，41，： | 1 |
| 16 | Representation in dynamical and embodied cognition显示文摘 | Keijzer F | 2002 | Cognitive Systems Research2002，，3： | 1 |
| 17 | An evidence-based clinical protocol for diagnosis of acute appendicitis decreased the use of computed tomography in children显示文摘 | Obinna O. Adibe Sejal R. Amin Erik N. Hansen Albert J. Chong Lena Perger Richard Keijzer Oliver J. Muensterer Keith E. Georgeson Carroll M. Harmon | 2011 | Journal of Pediatric Surgery2011，，1： | 1 |
| 18 | Optical diffusion in layered media显示文摘 | Keijzer M Star W M Storchi P R M | 1988 | Appl Opt1988，27，： | 1 |
| 19 | Anesthesia's effects on plasma glucose and insulin and cardiac hexokinase at similar hemodynamics and without major surgical stress in fed rats显示文摘 | Zuurbier CJ Keijzers PJ Koeman A | | 0，，： | 1 |
| 20 | Dual-hit hypothesis explainspulmonary hypoplasia in the nitrofen model of congenitaldiaphragmatic hernia显示文摘 | Keijzer R Liu J Deimling J | 2000 | Am J Pathol2000，156，： | 1 |
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