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| 1 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 2 | Xen and the art of virtualization显示文摘 | Paul Barham Boris Dragovic Keir Fraser Steven Hand Tim Harris Alex Ho Rolf Neugebauer Ian Pratt Andrew Warfield | 2003 | ACM SIGOPS Operating Systems Review2003，，5： | 6 |
| 3 | Football injuries of the ankle: A review of injury mechanisms, diagnosis and management显示文摘Football is the most popular sport worldwide and is associated with a high injury rate, most of which are the result of trauma from player contact. Ankle injuries are among the most commonly diagnosed injuries in the game. The result is reduced physical activity and endurance levels, lost game time, and considerable medical cost. Sports medicine professionals must employ the correct diagnostic tools and effective treatments and rehabilitation protocols to minimize the impact of these injuries on the player. This review examines the diagnosis, treatment, and postoperative rehabilitation for common football injuries of the ankle based on the clinical evidence provided in the current literature. | Raymond J Walls Keir A Ross Ethan J Fraser Christopher W Hodgkins Niall A Smyth Christopher J Egan James Calder John G Kennedy | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 4 | Xen and the art of virtualization显示文摘 | Paul Barham Boris Dragovic Keir Fraser Steven Hand Tim Harris Alex Ho Rolf Neugebauer Ian Pratt Andrew Warfield | 2003 | ACM SIGOPS Operating Systems Review2003，，5： | 2 |
| 5 | Evaluation of meta-astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model显示文摘 | Vaidyanathan G Friedman HS Keir ST | 1996 | Nucl Med Biol1996，23，： | 1 |
| 6 | Active control of connected plates using single and multiple actuators and error sensors显示文摘 | KEIR J KESSISSOGLOU N J NORWOOD C J | 2005 | Journal of Sound and Vibration2005，281，： | 1 |
| 7 | Systematic review of diffusion and perfusion imaging in acute ischemic stroke显示文摘 | Keir SL Wardlaw JM | 2000 | Stroke2000，31，11： | 1 |
| 8 | Ironing out greenhouse effects显示文摘 | Keir R S etal | 1991 | Nature1991，349，： | 1 |
| 9 | Hypoglycemia-Induced Anoxic Brain Injury Possibly Associated with Levofloxacin 显示文摘 | Lawrence KR Adra M Keir C | 2006 | J Inf2006，52，6： | 1 |
| 10 | PD-1 and its ligands in tolerance and immunity显示文摘 | Keir ME Butte MJ Freeman GJ | 2008 | Annu Rev Immunol2008，26，： | 1 |
| 11 | Is diffusion imaging appearance an independent predictor of outcome after ischemic stroke显示文摘 | Wardlaw JM Keir SL Bastin ME etal | 2002 | Neurolo- gy2002，59，9： | 1 |
| 12 | Early identification of secondary brain damage in subarachnoid hemorrhage: a role for glial fibrillary acidic protein显示文摘 | Petzold A Keir G Kerr M | 2006 | J Neurotrauma2006，23，7： | 1 |
| 13 | Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory mole cule to inhibit T cell responses显示文摘 | Butte MJ Keir ME | 2007 | Immunity2007，27，1： | 1 |
| 14 | Pilot study of the impact of massage therapy on sources and levels of distress in brain tumour patients 显示文摘 | Keir ST Saling JR | 2012 | BMJ Support Palliat Care2012，2，4： | 1 |
| 15 | Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern 显示文摘 | Petzold A Keir G Lira D | 2003 | Brain Res Bull2003，61，3： | 1 |
| 16 | Early Identification of Secondary Brain Damage in Subarachnoid Hemorrhage:A Role for Glial Fibrillary Acidic Protein显示文摘 | Petzold A Keir G Kerr M | | Neurotrauma0，23，7： | 1 |
| 17 | An Evaluation of Contrast Enhancement Techniques for Mammographic Breast Masses 显示文摘 | Sameer Singh Keir Boris | 2005 | IEEE Transactions on Information Technology in Biomedicine2005，9，1： | 1 |
| 18 | Criteria for a clinically informative serum biomarker in acute ischaemic stroke:a review of S100B显示文摘 | Dassan P Keir G Brown MM | 2009 | Cerebrovasc Dis2009，27，： | 1 |
| 19 | Xen and the art of virtualization显示文摘 | Paul Barbara Boris Dragovic Keir Fraser | 2003 | ACM Press2003，，： | 1 |
| 20 | Bronchial hyperresponsiveness induced by chronic treatment with albuterol : Role of sensory nerves 显示文摘 | Keir S Page C Spina D | 2002 | J Allergy Clin Immunol2002，110，3： | 1 |
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