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3篇 您的检索式:作者名="Keisuke Tsuchida"
    题名 作者 年代 出处 被引量
1Myostatin signaling regulates Akt activity via the regulation of miR-486 expression显示文摘Keisuke Hitachi Masashi Nakatani Kunihiro Tsuchida 2014International Journal of Biochemistry and Cell Biology2014,,:1
2Growth inhibitory effects of vitamin K2 on colon cancer cell lines viadifferent types of cell death including autophagy and apoptosis显示文摘Hideaki Kawakita Akihiko Tsuchida Keisuke Miyazawa Munekazu Naito Masatoshi Shigoka Bunso Kyo Masanobu Enomoto Tatehiko Wada Kenji Katsumata Kazuma Ohyashiki Masahiro Itoh Akio Tomoda Tatsuya Aoki 2009International Journal of Molecular Medicine2009,,6:1
3Dose escalation of external beam radiotherapy for high-risk prostate cancerdImpact of multiple high-risk factor显示文摘Objective:To retrospectively investigate the treatment outcomes of external beam radiotherapy with androgen deprivation therapy(ADT)in high-risk prostate cancer in three radiotherapy dose groups.Methods:Between 1998 and 2013,patients with high-risk prostate cancer underwent threedimensional conformal radiotherapy or intensity-modulated radiotherapy of 66 Gy,72 Gy,or 78 Gy with ADT.Prostate-specific antigen(PSA)relapse was defined using the Phoenix definition.PSA relapse-free survival(PRFS)was evaluated in each radiotherapy dose group.Moreover,high-risk patients were divided into H-1(patients with multiple high-risk factors)and H-2(patients with a single high-risk factor)as risk subgroups.Results:Two hundred and eighty-nine patients with a median follow-up period of 77.3 months were analyzed in this study.The median duration of ADT was 10.1 months.Age,Gleason score,T stage,and radiotherapy dose influenced PRFS with statistical significance both in univariate and multivariate analyses.The 4-year PRFS rates in Group-66 Gy,Group-72 Gy and Group-78 Gy were 72.7%,81.6%and 90.3%,respectively.PRFS rates in the H-1 subgroup differed with statistical significance with an increasing radiotherapy dose having a more favorable PRFS,while PRFS rates in H-2 subgroup did not differ with increase in radiotherapy dose.Conclusion:Dose escalation for high-risk prostate cancer in combination with ADT improved PRFS.PRFS for patients in the H-1 subgroup was poor,but dose escalation in those patients was beneficial,while dose escalation in the H-2 subgroup was not proven to be effective for improving PRFS.Rei Umezawa Koji Inaba Satoshi Nakamura Akihisa Wakita Hiroyuki Okamoto Keisuke Tsuchida Tairo Kashihara Kazuma Kobayashi Ken Harada Kana Takahashi Naoya Murakami Yoshinori Ito Hiroshi Igaki Keiichi Jingu Jun Itami 2019Asian Journal of Urology2019,6,2:0
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