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52篇 您的检索式:作者名="Kell DB"
    题名 作者 年代 出处 被引量
1“类代谢物”作为药物库设计和选择的标准显示文摘目前药物筛选库受限于预测'类药物'或'类先导物'理想药动学和结构标码的生物物理性质。然而,近来调查表明,为了进入细胞,多数药物需要溶质载体以正常转运自然产生的中间代谢物,很多药物还可能发生相似的相互作用。人代谢物组日益全面的概述使人们可以对'类代谢物'概念进行评价。我们利用有关的化学信息学分子标码空间比较了已知药物和库化合物与天然代谢物(内源分子)的相似性,其中,已知药物比多数库化合物与这些内源分子更类似。张双庆 李迎 刘克良 张振清 Dobson PD Patel Y Kell DB 2009国际药学研究杂志2009,36,4:3
2Ftow-injection electrospray ionization mass spectrometry of crude cell extracts for highthroughput bacterial identification 显示文摘Vaidyanathan S Kell DB Goodacre R 2002J Am Soc Mass Spectrom2002,13,2:1
3Viability and activity in readily culturable bacteria:A review and discussion of the practical issues显示文摘Kell DB Kaprelyants AS Weichart D 1998Antonie van Leeuwenhoek1998,73,2:1
4Adoption of the transiently non-euhurable state-a bacterial survival strategy显示文摘Mukamolova GV Kaprelyants AS Kell DB 2003Adv Mierob Physiol2003,47,:1
5A bacterial cytokine 显示文摘Mukamolova GV Kaprelyants AS Young DI Young M Kell DB 1998ProcNatlAcadSci USA1998,95,15:1
6High - throughput metabolic fingerprinting of legume silage fermentations via fourier transform infrared spectroscopy and chemometrics显示文摘Johnson HE Broadhurst D Kell DB 2004Appl Environ Microbiol2004,70,3:1
7Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases显示文摘KELL DB 2009BMC Med Genomics2009,2,:1
8Metabolic footprinting and systems biology:the medium is the message显示文摘Kell DB Brown M Davey HM 2005Nat Rev Microbiol2005,3,7:1
9The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation,and the roles of iron and fibrin(ogen)显示文摘Kell DB Pretorius E 2015Integrative Biology2015,7,1:1
10Dormancy in non-sporulating bacteria显示文摘Kaprelyants AS Gottschal JC Kell DB 1993FEMS Microbiol Rev1993,104,:1
11Metabolic footprinting and systems biology:the medium is the message显示文摘Kell DB Brown M Davey HM 2005Nat Rev Microbiol2005,3,7:1
12Systematic function- al analysis of the yeast genome 显示文摘Oliver SG Winson MK Kell DB 1998Trends in Biotechnolo- gy1998,16,9:1
13Discrimination between methicillin-resistant and methicillin-susceptible Staphylococcus aureus using pyrolysis mass spectrometry and artificial neural networks显示文摘Goodacre R Rooney PJ Kell DB 1998J Antimicrob Chemother1998,41,1:1
14Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor显示文摘 Kormer SS Kell DB 1999Arch Microbiol1999,172,1:1
15Why and when channelingcan decrease pool size at constant net flux in a simple dynamicchannel显示文摘Mendes P Kell DB Westerhoff HV 1996Biochim Biophys Acta1996,1289,2:1
16Channelling can decreasepoolsize显示文摘Mendes P Kell DB Westerhoff HV 1992Eur J Biochem1992,204,1:1
17Discrimination between methi- cillin-resistant and methicillin-susceptible Staphylococcus aureus u- sing pyrolysis mass speetrometry and artificial neural networks显示文摘Goodacre R Rooney PJ Kell DB 1998J Antilnicrob Chemother1998,41,1:1
18Variable selection in discriminant partial least-squares analysis显示文摘Alsberg BK Kell DB Goodacre R 1998Anal Chem1998,70,19:1
19Stimulation of the multiplication of Micrococcus luteus by an autocrine growth factor显示文摘Mukamolova GV Kormer SS Kell DB 1999Arch Microbiol1999,172,1:1
20Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other pro- gressive inflammatory and degenerative diseases显示文摘Kell DB 2009BMC Med Genomics2009,2,:1
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