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| 1 | 在血压控制不良的高血压患者中使用数字化干预的家庭和在线血压管理:随机对照试验显示文摘HOME BP试验(The home and online management and evaluation of blood pressure)的目的是评估在初级预防中结合自我监测和自我管理的数字化干预在高血压管理中的作用。研究者纳入英国76个治疗中心经过治疗但血压控制不好(>140/90 mm Hg, 1 mm Hg=0.133 kPa)并能上网的患者622例,进行自动确定主要终点的公开随机对照试验。 | McMa-nus RJ Little P Stuart B Morton K Raftery J Kelly J Bradbury K Zhang J Zhu S Murray E May CR Mair FS Michie S Smith P Band R Ogburn E AllenJ Rice C Nut-tall J Williams B Yardley L 陈嘉睿(译) 叶鹏(审校) | 2021 | 中华高血压杂志2021，29，5： | 15 |
| 2 | Platelet thromboxane(11-dehydro-Thromboxane B_2) and aspirin response in patients with diabetes and coronary artery disease显示文摘Aspirin(ASA) irreversibly inhibits platelet cyclooxygenase-1(COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on thromboxane generation was evaluated in patients with diabetes(DM) and cardiovascular disease. Thromboxane inhibition was assessed by measuring the urinary excretion of 11-dehydro-thromboxane B2(11dhTxB2), a stable metabolite of thromboxane A2. The mean baseline urinary 11dhTxB2 of DM was 69.6% higher than healthy controls(P = 0.024): female subjects(DM and controls) had 50.9% higher baseline 11dhTxB2 than males(P = 0.0004), while age or disease duration had no influence. Daily ASA ingestion inhibited urinary 11dhTxB2 in both DM(71.7%) and controls(75.1%, P < 0.0001). Using a pre-established cut-off of 1500 pg/mg of urinary 11dhTxB2, there were twice as many ASA poor responders(ASA 'resistant') in DM than in controls(14.8% and 8.4%, respectively). The rate of ASA poor responders in two populations of acute coronary syndrome(ACS) patients was 28.6 and 28.7%, in spite of a significant(81.6%) inhibition of urinary 11dhTxB2(P < 0.0001). Both baseline 11dhTxB2 levels and rate of poor ASA responders were significantly higher in DM and ACS compared to controls. Underlying systemic oxidative inflammation may maintain platelet function in atherosclerotic cardiovascular disease irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. | Luis R Lopez Kirk E Guyer Ignacio Garcia De La Torre Kelly R Pitts Eiji Matsuura Paul RJ Ames | 2014 | World Journal of Diabetes2014，5，2： | 13 |
| 3 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum显示文摘 | Nuss D Kelly RJ Croitoru DP | | 0，，04： | 1 |
| 4 | Clostridium difficile显示文摘 | KyneL Farrell RJ kelly CP | | 0，，03： | 1 |
| 5 | Diode laser contact transscleral cyclophotocoagulation:getting the most from the G-probe显示文摘 | Noecker RJ Kelly T Patterson E | 2004 | Ophthalmic Surg Lasers Imaging2004，35，2： | 1 |
| 6 | High frequency hearing loss correlated with mutations in the GJB2 gene显示文摘 | Stephen A Wilcox Kerryn Saunders Amelia H Osborn Angela Arnold Julia Wunderlich Therese Kelly Veronica Collins Leah J Wilcox RJ McKinlay Gardner Maria Kamarinos Barbara Cone-Wesson Robert Williamson Hans-Henrik M. Dahl | 2000 | Human Genetics2000，，4： | 1 |
| 7 | Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma 显示文摘 | Gilbertson RJ Perry RH Kelly PJ | 1997 | Cancer Res1997，57，： | 1 |
| 8 | The management of human bite injuries of he hand显示文摘 | Kelly IP Cunnet RJ Smith EG | 1996 | Injury1996，27，7： | 1 |
| 9 | Tupuseleiamides an basiliskamides,new acyldipeptides and antifungal polyketides produced in culture by a Bacillus laterosporus isolated obtained from a tropical marine habitat显示文摘 | Kelly MT Andersen RJ | 2002 | J Nat Prod2002，65，10： | 1 |
| 10 | Absent p53 immunohistochemical staining in a pituitary carcinomas 显示文摘 | Kumar K Macaulary RJ Kelly M | 2001 | Can J Neurol Sci2001，28，： | 1 |
| 11 | Molecular cloning of a fourth member of a human alpha ( 1,3 ) fucosyltransferase gene farmly, multiple homologous sequence that determine expression of the LewisX sialyl Lewisx, and difucosyl sialy Lewis X epitopes显示文摘 | Weston BW Smith PL Kelly RJ | 1992 | J Biol Chem1992，267，24： | 1 |
| 12 | A phase I/II study of sepantronium bromide(YM155,survivin suppressor)with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer显示文摘 | Kelly RJ Thomas A Rajan A | 2013 | Ann Oncol2013，24，： | 1 |
| 13 | Impacting tumor cell fate by targeting the inhibitor of apoptosis protein survivin 显示文摘 | Kelly RJ Lopez Chavez A Citriu D | 2011 | Mol Cancer2011，，10： | 1 |
| 14 | Resource pricing and the evolution of congestion control显示文摘 | GIBBENS RJ KELLY FP | 1999 | Automatica1999，35，12： | 1 |
| 15 | Identitleation of dendritic cell subsets responding to genital infection by Chlamydia muridarum 显示文摘 | Moniz RJ Chan AM Kelly KA | 2009 | FEMS Immunol Med Microbiol2009，55，2： | 1 |
| 16 | Immunohistochemical detection of epidermal growth factor receptors on human colonic carcinomas显示文摘 | Steele RJ Kelly P Ellul B | 1990 | Br J Cancer1990，61，： | 1 |
| 17 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum 显示文摘 | Nuss D Kelly RJ Croitoru DP | 1998 | J Pediatr Surg1998，33，4： | 1 |
| 18 | Axitinib (AG-013736)显示文摘 | Kelly RJ Rixe O | | 0，，： | 1 |
| 19 | Renal toxicity of targeted therapies显示文摘 | Kelly RJ Billemont B Rixe O | 2009 | Targ Oncol2009，4，2： | 1 |
| 20 | Leucopenia associated with lamotrigine显示文摘 | Nicholson RJ Kelly KP Grant IS | 1995 | BMJ1995，310，6978： | 1 |
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