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| 1 | Immune checkpoint inhibitor-related hepatotoxicity:A review显示文摘The application of immune checkpoint inhibitors(ICI)in advanced cancer has been a major development in the last decade.The indications for ICIs are constantly expanding into new territory across different cancers,disease stages and lines of therapy.With this increased use,adverse events including immune checkpoint inhibitor-related hepatotoxicity(ICH)have emerged as an important clinical problem.This along with the introduction of ICI as first-and second-line treatments for advanced hepatocellular carcinoma makes ICH very relevant to gastroenterologists and hepatologists.The incidence of ICH varies between 1%-20%depending on the number,type and dose of ICI received.Investigation and management generally involve excluding differential diagnoses and following a stepwise escalation of withholding or ceasing ICI,corticosteroid treatment and adding other immunosuppressive agents depending on the severity of toxicity.The majority of patients with ICH recover and some may even safely recommence ICI therapy.Guideline recommendations are largely based on evidence derived from retrospective case series which highlights a priority for future research. | Devika Remash David S Prince Catriona McKenzie Simone I Strasser Steven Kao Ken Liu | 2021 | World Journal of Gastroenterology2021，27，32： | 9 |
| 2 | Identification and functional analysis of a locus for improvement of lodging resistance in rice显示文摘 | TAKAYUKI K KEN I | 2004 | Plant physiology2004，134，2： | 1 |
| 3 | Genotoxic ; stress abrogates renewalolMelanoc; yte stem cells by triggering their differentiation显示文摘 | Ken I Takahiro A Nguyen TB | 2009 | CELL2009，137，： | 1 |
| 4 | Role of TSC-mTOR pathway in diabetic nephropathy显示文摘 | Ken I | 2008 | Diabe Res Cli Pra2008，82，1： | 1 |
| 5 | Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica 显示文摘 | Hsu B Coupar I M Ken N | 2006 | Food Chemistry2006，98，2： | 1 |
| 6 | Enzymatic hydrolysis of cellu- lose | is greatly accelerated via its conversion to the cellulose 11 hy- drate form显示文摘 | MASAHISA W MASAKAZU I KEN T | 2010 | Polymer Degradation and Stability2010，，4： | 1 |
| 7 | Differential Positioning Experiment Using Two Geostationary Satellites 显示文摘 | KEN I KAZUKI H MINORU I | 1999 | IEEE Transactions on Aerospace and Electronic Systems1999，35，3： | 1 |
| 8 | Improved algorithm for estimating pulse repetition intervals显示文摘 | Ken I N Massaaki K | 2000 | IEEE Trans on Aerospace and Electronic Systems2000，36，2： | 1 |
| 9 | Apoptosis and tumor angiogesis in cervical cancer after preoperative chemotherapy显示文摘 | MASATSUGU UEDA KEN UEKI KOJI KUMAGA I | 1999 | Cancer Res1999，58，： | 1 |
| 10 | Elevated pyruvate, orthophosphate dikinase (PPDK) activity alters carbon metabolism in C3 transgenic potatoes with a Ca maize PPDK gene显示文摘 | KEN I YASUNOBU O TERUO I | 1998 | Physiol Plantarum1998，103，3： | 1 |
| 11 | Molecular mechanism activating Nrf2-Keapl pathway in regulation of adaptive response to electrophiles 显示文摘 | KEN ITOH KIT I TONG MASAYUKI YAMAMOTO | 2004 | Free Radical Biology Med2004，36，： | 1 |
| 12 | Changes in vitellin and other yolk proteins during embryonic development in the silkworm,bombyx morl显示文摘 | KEN I OKITSUGU Y | 1980 | Insect Physiology1980，26，： | 1 |
| 13 | Are contents of rubisco, soluble protein and nitrogen in flag leaves of rice controlled by the same genetics显示文摘 | Ken I Noriko K Kiyomi O | 2001 | Journal of Experimental Botany2001，52，362： | 1 |
| 14 | Hepatic resection for meta-static tumors from gastric cancer 显示文摘 | Keiichi O Takashi M Ken I | 2002 | Ann Surg2002，235，1： | 1 |
| 15 | Locus prl5 improves lodging resistance of rice by delaying senescence and increasing carbohydrate accumulation显示文摘 | KASHIWAGI T YUKA M NAOKI H KEN I | 2006 | Plant Physiology and Biochemistry2006，44，： | 1 |
| 16 | Clinicoradiologic features of vertebrobasilar dolichoectasia in stroke patients显示文摘 | Yoshikazu N Takehisa H Ken I | 2010 | Journal of Stroke and Cerebrovascular Disease2010，，： | 1 |
| 17 | Phytochemicals and antioxidant properties of solvent extracts from Japonica rice bran 显示文摘 | Phoency Lai Ken Yuun l i Shin l u | 2009 | Food Chemistry2009，117，3： | 1 |
| 18 | Improved utilisation of renewable resources: New important derivatives of glycerol显示文摘 | Arno B Jens E Ken I | 2008 | Green Chemistry2008，10，： | 1 |
| 19 | Possible protective role for 3', 4'-dihydroxyflavones induced by enhanced UV-B in a UV-tolerant rice cultivar显示文摘 | Ken R M Gregory J T Malcolm I W | 1998 | Phytochemistry1998，49，： | 1 |
| 20 | Synthesis andantimuscarinic properties of q-uinuclidin-3-yll, 2,3 ,4-tetrahydroisoquinoline-2-carboxylate derivatives asnovel muscarinic receptor antagonists! 显示文摘 | RYO N YASUHIRO Y KEN I | 2005 | J MedChem2005，48，： | 1 |
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