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| 1 | AHA/ASA关于卒中和短暂性脑缺血发作患者卒中预防推荐的更新显示文摘在卒中和短暂性脑缺血发作(transient ischemic attack,TIA)患者卒中预防推荐发表以后,美国心脏协会和美国卒中协会(American Heart Association/American Stroke Association,AHA/ASA)著述委员会对最近的一些试验结果进行了回顾。本文的目的是对这些新资料做简要回顾、更新某些推荐意见并说明进行这些修改的理由。在2个领域已发表了一些新的重要临床试验结果:(1)在非心源性栓塞所致缺血性卒中或TIA患者卒中二级预防中具体抗血小板药的应用;(2)他汀类药物在预防卒中复发中的应用。 | Robert J. Adams Greg Albers Mark J. Alberts Oscar Benavente Karen Furie Larry B. Goldstein Philip Gorelick Jonathan Halperin Robert Harbaugh S. Claiborne Johnston Irene Katzan Margaret Kelly-Hayes Edgar J. Kenton Michael Marks Ralph L. Sacco Lee H. Schwamm 赵洪芹 李海峰 (译) | 2008 | 国际脑血管病杂志2008，16，4： | 123 |
| 2 | State-of-the-Art management of knee osteoarthritis显示文摘Osteoarthritis(OA) is the most common type of arthritis found in the United States' population and is also the most common disease of joints in adults throughout the world with the knee being the most frequently affected of all joints. As the United States' population ages along with the increasing trends in obesity prevalence in other parts of the world, it is expected that the burden of OA on the population, healthcare system, and overall economy will continue to increase in the future without making major improvements in managing knee OA. Numerous therapies aim to reduce symptoms of knee OA and continued research has helped to further understand the complex pathophysiology of its disease mechanism attempting to uncover new potential targets for the treatment of OA. This review article seeks to evaluate the current practices for managing knee OA and discusses emerging therapies on the horizon. These practices include non-pharmacological treatments such as providing patient education and self-management strategies, advising weight loss, strengthening programs, and addressing biomechanical issues with bracing or foot orthoses. Oral analgesics and anti-inflammatories are pharmacologicals that are commonly used and the literature overall supports that some of these medications can be helpful for managing knee OA in the short-term but are less effective for long-term management. Additionally, more prolonged use significantly increases the risk of serious associated side effects that are not too uncommon. Diseasemodifying osteoarthritis drugs are being researched as a treatment modality to potentially halt or slow disease progression but data at this time is limited and continued studies are being conducted to further investigate their effectiveness. Intra-articular injectables are also implemented to manage knee OA ranging from corticosteroids to hyaluronans to more recently plateletrich plasma and even stem cells while several other injection therapies are presently being studied. The goal of developing new treatment strategies for knee OA is to prolong the need for total knee arthroplasty which should be utilized only if other strategies have failed. High tibial osteotomy and unicompartmental knee arthroplasty are potential alternatives if only a single compartment is involved with more data supporting unicompartmental knee arthroplasty as a good treatment option in this scenario. Arthroscopy has been commonly used for many years to treat knee OA to address degenerative articular cartilage and menisci, however, several high-quality studies have shown that it is not a very effective treatment for the majority of cases and should generally not be considered when managing knee OA. Improving the management of knee OA requires a multi-faceted treatment approach along with continuing to broaden our understanding of this complex disease so that therapeutic advancements can continue to be developed with the goal of preventing further disease progression and even potentially reversing the degenerative process. | Kenton H Fibel Howard J Hillstrom Brian C Halpern | 2015 | World Journal of Clinical Cases2015，3，2： | 19 |
| 3 | SPORTS1.0: A Tool for Annotating and Profiling Non-coding RNAs Optimized for rRNA-and tRNA-derived Small RNAs显示文摘High-throughput RNA-seq has revolutionized the process of small RNA(sRNA) discovery, leading to a rapid expansion of s RNA categories. In addition to the previously wellcharacterized sRNAs such as micro RNAs(mi RNAs), piwi-interacting RNAs(piRNAs), and small nucleolar RNA(sno RNAs), recent emerging studies have spotlighted on t RNA-derived s RNAs(tsRNAs) and rRNA-derived s RNAs(rs RNAs) as new categories of s RNAs that bear versatile functions. Since existing software and pipelines for sRNA annotation are mostly focused on analyzing mi RNAs or pi RNAs, here we developed the sRNA annotation pipeline optimized for rRNA-and tRNA-derived sRNAs(SPORTS1.0). SPORTS1.0 is optimized for analyzing ts RNAs and rsRNAs from sRNA-seq data, in addition to its capacity to annotate canonical sRNAs such as mi RNAs and pi RNAs. Moreover, SPORTS1.0 can predict potential RNA modification sites based on nucleotide mismatches within sRNAs. SPORTS1.0 is precompiled to annotate s RNAs for a wide range of 68 species across bacteria, yeast, plant, and animal kingdoms, while additional species for analyses could be readily expanded upon end users' input. For demonstration, by analyzing sRNA datasets using SPORTS1.0, we reveal that distinct signatures are present in tsRNAs and rsRNAs from different mouse cell types. We also find that compared to other s RNA species, tsRNAs bear the highest mismatch rate, which is consistent with their highly modified nature. SPORTS1.0 is an opensource software and can be publically accessed at http://gffzz188fe103f8f1460as0qwfupuuuwvb6op9.ffgz.tsg.suse.edu.cn/junchaoshi/sports1.0. | Junchao Shi Eun-A Ko Kenton M.Sanders Qi Chen Tong Zhou | 2018 | Genomics, Proteomics & Bioinformatics2018，16，2： | 6 |
| 4 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 5 | Measurement of muscle activity with magnetic resonance elastography显示文摘 | Guido Heers Thomas Jenkyn M. Alex Dresner Marc-Oliver Klein Jeffrey R Basford Kenton R Kaufman Richard L Ehman Kai-Nan An | 2003 | Clinical Biomechanics2003，，6： | 2 |
| 6 | A functional role for the ‘fibroblast‐like cells’ in gastrointestinal smooth muscles显示文摘 | MasaakiKurahashi HaifengZheng LauraDwyer Sean M.Ward SangDon Koh Kenton M.Sanders | 2011 | The Journal of Physiology2011，，3： | 2 |
| 7 | Platelet‐derived growth factor receptor α‐positive cells in the tunica muscularis of human colon显示文摘 | Masaaki Kurahashi Yasuko Nakano Grant W. Hennig Sean M. Ward Kenton M. Sanders | 2012 | J. Cell. Mol. Med2012，，7： | 2 |
| 8 | Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine显示文摘 | Sang DonKoh Kenton M.Sanders Sean M.Ward | 2004 | The Journal of Physiology2004，，1： | 2 |
| 9 | Open butch urethropexy has a low rate of preoperative complications 显示文摘 | Kenton K Oldham L Brubaker L | 2002 | Obstet Gynecol2002，187，： | 1 |
| 10 | An Accurate Model of Wave Refraction over Shallow Water 显示文摘 | Manuel N Gamito F Kenton Musgrave | 2002 | Computer Graphics (S0097-8930)2002，26，2： | 1 |
| 11 | Open Burch urethropexy has a low rate of perioperative complications显示文摘 | Kenton K Oldham L Brubaker L | 2002 | Am J Obstet Gynecol2002，187，： | 1 |
| 12 | Severe thrombocyto-penia predicts outcome in neonates with necrotizing enterocolitis显示文摘 | Kenton AB 0'Donovan D Cass DL | 2005 | J Perinatol2005，25，1： | 1 |
| 13 | Effect of peer support on prevention of postnatal depression among high risk women : muhisite randomized controlled trial显示文摘 | Dennis CL Hodnett E Kenton L | 2009 | BMJ2009，338，： | 1 |
| 14 | Evaluation and Outcome Measures in the Treatment of Female Urinary Stress Incontinence: International Urogynecological Associa- tion (IUGA) Guidelines for Research and Clinical Practice显示文摘 | Ghoniem G Stanford E Kenton K | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，1： | 1 |
| 15 | Idiopathic Pulmonary Artery Aneurysm显示文摘 | Subrato J. Deb Kenton J. Zehr Raymond C. Shields | 2005 | The Annals of Thoracic Surgery2005，，： | 1 |
| 16 | Interstitial cells of cajal generate electrical slow wave in the murine stomach显示文摘 | Tamas O Sean MW Kenton MS | | 0，，： | 1 |
| 17 | Sinus of Valsalva Aneurysms—47 Years of a Single Center Experience and Systematic Overview of Published Reports显示文摘 | Sherif Moustafa Farouk Mookadam Leslie Cooper Guleid Adam Kenton Zehr John Stulak David Holmes | 2007 | The American Journal of Cardiology2007，，： | 1 |
| 18 | Expression of menmbers of the Bcl-2 gene family in the immature rat ovary : equine ehorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels 显示文摘 | Tilly JL Tilly KI Kenton ML | 1995 | Endocrinology1995，136，1： | 1 |
| 19 | Expression of members of the bel -2 gene family in the immature rat ovary: equine ehorionic gon- adotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl -2 and bel-xlong messenger ribonueleic acid levels显示文摘 | Tilly JL Tilly KI Kenton ML | 1995 | Endocrinology1995，136，1： | 1 |
| 20 | Expression of members of the bcl-2 gent family in the immature rat ovary: equine chorionic gonadotropin-mcdia- ted inhibition of granulasa cell apoptosis is associated with decreased bax and constitutive hel-2 and bel-xlong messenger ribonuehic acid levels 显示文摘 | Tilly JL TiUy K I Kenton ML | 1995 | En- docrinology1995，136，1： | 1 |
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