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| 1 | Non-invasive diagnosis of advanced fibrosis and cirrhosis显示文摘Liver cirrhosis is a common and growing public health problem globally.The diagnosis of cirrhosis portends an increased risk of morbidity and mortality.Liver biopsy is considered the gold standard for diagnosis of cirrhosis and staging of fibrosis.However,despite its universal use,liver biopsy is an invasive and inaccurate gold standard with numerous drawbacks.In order to overcome the limitations of liver biopsy,a number of non-invasive techniques have been investigated for the assessment of cirrhosis.This review will focus on currently available non-invasive markers of cirrhosis.The evidence behind the use of these markers will be highlighted,along with an assessment of diagnostic accuracy and performance characteristics of each test.Non-invasive markers of cirrhosis can be radiologic or serum-based.Radiologic techniques based on ultrasound,magnetic resonance imaging and elastography have been used to assess liver fibrosis.Serum-based biomarkers of cirrhosis have also been developed.These are broadly classified into indirect and direct markers.Indirect biomarkers reflect liver function,which may decline with the onset of cirrhosis.Direct biomarkers,reflect extracellular matrix turnover,and include molecules involved in hepatic fibrogenesis.On the whole,radiologic and serum markers of fibrosis correlate well with biopsy scores,especially when excluding cirrhosis or excluding fibrosis.This feature is certainly clinically useful,and avoids liver biopsy in many cases. | Suraj Sharma Korosh Khalili Geoffrey Christopher Nguyen | 2014 | World Journal of Gastroenterology2014，20，45： | 28 |
| 2 | Trend analysis and comparison of basic parameters for tunnel blast design models显示文摘One of the most important factors influencing on a tunnel blast efficiency is the proper design of blasting pattern. Among blasting parameters, blasthole diameter and tunnel face area are more significant so that any change in these parameters could finally affect on specific charge and specific drilling. There are mainly two groups of methods for tunnel blast design categorized based on the parallel cuts and angular cuts. In this research, a software for tunnel blast design was developed to analyze the effect and sensitiveness of blasthole diameter and the tunnel face area on blasting results in different blast design models. Using the software, it is quickly possible to determine specific charge, specific drilling and number of blastholes for each blast design model. The relations between both of blasthole diameters and the tunnel face area with the above parameters in different blast design models were then investigated to yield a set of equations with the highest correlations to compare the methods. The results showed that angular method requires more blasthole numbers than parallel method in similar condition(blasthole diameter and tunnel face area). Moreover, the specific charge values yielded by the two methods are approximately the same and very close together. | Khalili Soroush Yavary Mehdi Ebrahimabadi Arash | 2015 | International Journal of Mining Science and Technology2015，25，4： | 7 |
| 3 | Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn’s Disease显示文摘 | Ashwin N. Ananthakrishnan Hamed Khalili Leslie M. Higuchi Ying Bao Joshua R. Korzenik Edward L. Giovannucci James M. Richter Charles S. Fuchs Andrew T. Chan | 2012 | Gastroenterology2012，，3： | 6 |
| 4 | Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury显示文摘To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells. | Fatemeh Anbari Mohammad Ali Khalili Ahmad Reza Bahrami Arezoo Khoradmehr Fatemeh Sadeghian Farzaneh Fesahat Ali Nabi | 2014 | Neural Regeneration Research2014，9，9： | 6 |
| 5 | Discrete simulation and micromechanical analysis of two-dimensional saturated granular media显示文摘In this study,a novel approach to incorporate the pore water pressure in the discrete element method(DEM) to comprehensively model saturated granular media was developed.A numerical model was constructed based on the DEM by implanting additional routines in the basic DEM code;pore water pressure calculations were used with a two-dimensional(2D) model to simulate the undrained behavior of saturated granular media.This model coupled the interaction of solid particles and the pore fluid in saturated granular media.Finally,several 2D undrained shear tests were simulated.The test results showed that the model could predict the response of the saturated granular soil to shear loading.The effect of initial compaction was investigated.Biaxial tests on dense and loose specimens were conducted,and the effect of the initial density on the change in shear strength and the volume change of the system was investigated.The overall behavior of loose and dense specimens was phenomenologically similar to the real granular material.Constant volume tests were simulated,and the results were compared to those from the coupled model.Induced anisotropy was micromechanically investigated by studying the contact force orientation.The change in anisotropy depended on the modeling scheme.However,the overall responses of the media obtained using the coupled and constant volume methods were similar. | Younes Khalili Ahmad Mahboubi | 2014 | Particuology2014，12，4： | 5 |
| 6 | Asymptomatic seminal infection of herpes simplex virus:impact on male infertility显示文摘In more than half of infertile men,the cause of their infertility is unknown.Several studies revealed the role of viral infections in male infertility.The aim of the present study was to determine the prevalence of herpes simplex virus-1 (HSV-1) and HSV-2 in semen from asymptomatic infertile male patients,and its association with altered semen parameters.A total of 70 semen samples were collected from infertile men who attended the Research and Clinical Center for Infertility in Yazd,Iran.Semen analysis and diagnostic real-time PCR using specific primers and probes for HSV-1 and HSV-2 DNA were performed.Comparison of semen parameters between virally infected and non-infected samples were performed with independent t-test and Mann-Whitney test.Semen analysis showed that infertile men fell into two groups,the male factor group and the unexplained group.HSV-1 and HSV-2 DNA was detected in 16 (22.9%) and 10 (14.3%) of 70 semen samples,respectively.All HSV-positive samples had abnormal semen parameters (the male factor group).Although HSV infection was not associated with sperm motility and morphological defects,it was correlated with lower sperm count in the seminal fluid.The findings suggest that asymptomatic seminal infection of HSV plays an important role in male infertility by adversely affecting sperm count. | Seyed Hamidreza Monavari Mostafa Salehi vaziri Mohammadali Khalili Mahmoud Shamsi-Shahrabadi Hossein Keyvani Hamidreza Mollaei Mehdi Fazlalipour | 2013 | The Journal of Biomedical Research2013，27，1： | 4 |
| 7 | Fouling of WO3 nanoparticle-incorporated PSf membranes in ultrafiltration of landfill leachate and dairy a combined wastewaters: An investigation using model显示文摘As fouling has always been a major drawback of membrane technology, qualitative and quantitative understanding of membrane fouling mechanisms therefore becomes vital in order to help push membrane separation technologies forward. In this study, firstly, self-cleaning Polysulfone(PSf) membranes were synthesized by incorporation of WO_3nanoparticles(0–2 wt%) and subsequent UV irradiation for efficient ultrafiltration(UF)of landfill leachate and dairy wastewater. The membrane surface properties were characterized by scanning electron microscopy(SEM) and contact angle analysis. It was found that UV-irradiated membranes exhibited higher percent COD removals due to the hydrophilicity and photocatalytic properties of nano-WO_3. Subsequently, in order to analyze the fouling behavior of the membranes, a set of experimental data from cross-flow ultrafiltration of municipal landfill leachate and industrial dairy wastewater at 25 °C was obtained. A new model of membrane fouling was proposed based on a resistance in series concept and was fitted well with all experimental data sets.Almost all relative errors of prediction provided by the proposed model were less than 2.5%. In addition, it was revealed that this newly-developed model exhibited smooth transition between the common successive twostep pore blockage-cake filtration phenomena and thus eliminates the need to use separate equations for different mechanisms. | Majid Peyravi Mohsen Jahanshahi Soodabeh Khalili | 2017 | Chinese Journal of Chemical Engineering2017，25，6： | 4 |
| 8 | A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn’s Disease and Ulcerative Colitis显示文摘 | Ashwin N. Ananthakrishnan Hamed Khalili Gauree G. Konijeti Leslie M. Higuchi Punyanganie de Silva Joshua R. Korzenik Charles S. Fuchs Walter C. Willett James M. Richter Andrew T. Chan | 2013 | Gastroenterology2013，，： | 3 |
| 9 | Co纳米粒子催化无溶剂条件下一锅四组分法高效合成1,4-二氢吡啶衍生物(英文)显示文摘A straightforward and general method has been developed for the synthesis of C5-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction. | Javad SAFARI Sayed Hossein BANITABA1 Shiva DEHGHAN KHALILI | 2011 | 催化学报2011，32，12： | 3 |
| 10 | Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior显示文摘服的外皮为集成是必要的并且为大多数行为被要求的信息处理。当神经原从室的地区连续地移居联合进特定的外皮的层时,服的外皮的精致地精确的 laminar 组织在胚胎的开发期间产生。当时指南为设计神经原移植责骂的光线的神经胶质行为, pre-formed 脉管的网络为 GABAergic interneuron 移植提供支持和指导暗示。这研究提供新奇概念、机械学的卓见进 vascular-neuronal 相互作用的这个范例,揭示伽马氨基丁酸并且它经由胚胎的前脑 endothelial 房间的调停受体的发信号的新机制。与二个新 endothelial 房间的使用,特定的有条件的老鼠 GABA 小径当模特儿(Gabrb3 Tie2-Cre 和 Vgat 我们显示出的 Tie2-Cre ), 从 endothelial 房间的伽马氨基丁酸版本的那部分或完全的损失在 embryogenesis 期间导致脉管的缺点并且损害长途的移植并且外皮的 interneurons 放。使不安的 endothelial 的下游的效果导出房间的伽马氨基丁酸发信号是批评的,导致上次修改到外皮的电路和坚持的行为的赤字。而且,我们说明在支持他们血大脑障碍性质的迁居, angiogenesis 和获得的前脑 endothelial 房间发信号的伽马氨基丁酸的激活的新机制。我们的调查结果揭开并且阐明在从表明小径的古典 neuronal 伽马氨基丁酸是不同的并且在 neuropsychiatric 疾病的病原学和 pathophysiology 上打开新灯的 CNS 表明小径的新奇 endothelial 伽马氨基丁酸例如孤独性光谱混乱,癫痫,焦虑,消沉和精神分裂症。 | Suyan Li Peeyush Kumar Sampada Joshee Timo Kirschstein Sivan Subburaju Jahan S Khalili Jonas Kloepper Chuang Du Abdallah Elkhal Gabor Szabo Rakesh K Jain Rudiger Kohling Anju Vasudevan | 2018 | Cell Research2018，28，2： | 3 |
| 11 | 自体结膜角巩膜缘移植治疗原发性翼状胬肉显示文摘目的:评价自体结膜角巩膜缘移植术治疗原发性翼状胬肉的有效性。
方法:原发性翼状胬肉患者15例(15眼),接受自体结膜角巩膜缘移植术。切除翼状胬肉后,植片的角膜缘部分与翼状胬肉切除处的角膜缘对位缝合,植片的上皮面向上。纤维血管组织在原翼状胬肉区遮盖角膜1mm以上定为复发。
结果:随访平均8mo,所有的患者既无一例复发也无并发症发生。
结论:单纯翼状胬肉切除联合自体结膜角巩膜缘移植是一种治疗原发性翼状胬肉安全有效的手术方法。 | Mahmoud Jabbbarvand Mohammad Reza Khalili Mohammad Taher Rajabi | 2008 | 国际眼科杂志2008，8，3： | 2 |
| 12 | 工业AA1200铝合金薄板拉伸成形模拟和实验研究(英文)显示文摘对工业AA1200铝合金薄板拉伸成形的模拟和实验结果进行比较和评估。采用单向拉伸试验得到模拟所需输入参数。根据von Mises和Hill-1948屈服准则,采用Abaqus/Explicit有限元软件分析成形过程。将冲压力和应变分布的模拟结果与实验结果进行比较和验证。结果表明:在这两种情况下,使用各向异性屈服准则模拟的结果与实验结果更吻合。 | Reza ESMAEILIZADEH Kourosh KHALILI Bagher MOHAMMADSADEGHI Hossein ARABI | 2014 | Transactions of Nonferrous Metals Society of China2014，24，2： | 2 |
| 13 | Herd-prevalence of Coxiella burnetii(Q fever) antibodies in dairy cattle farms based on bulk tank milk analysis显示文摘Objective:To determine the prevalence of Coxiella burnetii(C.burnetii) antibody positive randomly selected dairy herds in southeast Iran(Kerman).Methods:Bulk tank milk samples were collected randomly from 44 sufficiently large commercial dairy herds,included near 12 000 dairy cattle,in Kerman(The largest province of Iran),southeast Iran.The samples were tested for antibodies against C.burnetii using the commercial CHEKIT(?) Q fever antibody ELISA Test Kit(Idexx,Liebefeld-Bern,Switzerland).Results:The prevalence of positive,negative and intermediate herds were 45.4%,43.2%and 11.4%,respectively.Conclusions:The result supports the hypothesis of high prevalence and endemic pattern of Q fever in Iran.This investigation highlights the importance of further studies on Q fever in Iran. | Mohammad Khalili Ehsanollah Sakhaee Mohammad Reza Aflatoonian Naser Shahabi-Nejad | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 1 |
| 14 | Wave propagation analysis of two-phase saturated porous media using coupled finite-infinite element method显示文摘 | Khalili N Yazdchi M Valliappan S | 1999 | Soil Dynamics and Earthquake Engineering1999，18，2： | 1 |
| 15 | Determination of Fractal Dimensions of Solid Carbons From Gas and Liquid Phase Adsorpsion Isotherms显示文摘 | Khalili N R Pan M Sandi G | 2000 | Carbon2000，38，： | 1 |
| 16 | Free vibration analysis of sandwich structures with a flexible functionally graded syntactic core 显示文摘 | RAHMANI O KHALILI S M R MALEKZADEH K | 2009 | Composite Structures2009，91，： | 1 |
| 17 | PAH source finger prints for coke ovens, diesel and gasoline engines, highway tunnels, and wood combustion emissions显示文摘 | Khalili N R Scheff P A Holsen T M | 1995 | Atmospheric En- vironment1995，29，4： | 1 |
| 18 | Utilization of Time-Based Me-teorological Droughts to Investigate Occurrence of Stream flowDroughts显示文摘 | Ali Asghari Tabrizi Davar Khalili | 2010 | Water Resource Manage2010，，24： | 1 |
| 19 | Drained cavity expansion in sands exhibiting particle crushing 显示文摘 | Russell A R Khalili N | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，26，3： | 1 |
| 20 | Electromagnet-ism-like mechanism and simulated annealing algorithms for flowshop scheduling problems minimizing the total weighted tardinessand makespan显示文摘 | Naderi B Tavakkoli-Moghaddam R Khalili M | 2010 | Knowledge-based Systems2010，23，2： | 1 |
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