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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | Differential roles of EPS8 in carcinogenesis:Loss of protein expression in a subset of colorectal carcinoma and adenoma显示文摘AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment. | Wael M Abdel-Rahman Salla Ruosaari Sakari Knuutila Pivi Peltomki | 2012 | World Journal of Gastroenterology2012，18，29： | 5 |
| 3 | Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis显示文摘我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布,疾病严厉,和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析,控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) , 20 mg tadalafil (N = 510 ) ,或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引,性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上,与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ,成功的性交)分别地,在安慰剂与33.4%相比组织( P < 0.001 ),并且分别地,在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说, tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。 | Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki Choi Andrew Wai Chun Yip Wei Shen Vladimir Kopernicky | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 4 | 无机硒和有机硒对羊瘤胃内容物的脂肪酸组成、瘤胃细菌和纤毛虫的影响显示文摘试验旨在研究3个月每天等摩尔饲喂有机硒和无机硒对瘤胃内容物脂肪酸组成、瘤胃细菌和原生动物的影响。12只羊饲喂含有干草1 380 g·只-1DM和大麦450 g·只-1DM的基础日粮,基础日粮中含硒0.16 mg·kg-1DM。将羊随机分成3组,包括饲喂基础日粮(对照组)、在基础日粮中添加无机硒0.4 mg·kg-1DM(Na2SeO3,ISe)、在基础日粮中添加有机硒0.4mg·kg-1DM(酵母硒,OSE)。测定瘤胃内容物(TRC)中脂肪酸(FA)含量、细菌数(BF)和纤毛原虫数(PF)。OSe组的TRC中C18:2cis-9,trans-11的含量显著降低(P<0.05),α-亚麻酸浓度(C18:3 N 3;LNA)极显著增加(P<0.01)。ISe组BF中肉豆蔻酸(C14:0;P<0.05)、棕榈酸(P<0.01)和中链脂肪酸(P<0.01)含量下降,长链脂肪酸(P<0.05)、硬脂酸(C18:0,P<0.01)、花生酸(C20:0,P<0.001)和山嵛酸(C22:0,P<0.01)含量升高。OSe组BF的辛酸(C8:0,P<0.001)、二十碳四烯酸(C20:4 n6,P<0.01)、二十碳三烯酸(C20:3 n3,P<0.01)浓度增加。ISe组PF的十二碳六烯酸(C22:6 n3)和tricosylic酸(C23:0,P<0.05)含量下降。添加OSe可以增加LNA的含量(P<0.01),降低棕榈油酸的含量(C16:1,P<0.05)。结果表明,饲粮中添加OSe可以通过瘤胃微生物影响多不饱和脂肪酸(PUFA)含量,特别是瘤胃纤毛虫,使多不饱和脂肪酸氢化成更饱和脂肪酸。 | Kiidayová S Mihaliková K Siroka P Cobanová K Váradyová Z | 2014 | 饲料博览2014，0，9： | 2 |
| 5 | Solution structure of the epithelial cadherin domain responsible for selective cell adhesion显示文摘 | Overduin M Harvey TS Bagby S Tong KI Yau P Takeichi M Ikura M | | 0，，： | 2 |
| 6 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 7 | Simulating electron transfer attachment to a positively charged model peptide 显示文摘 | ANUSIEWICZ I BERDYS-KOCHANSKA J SKURS- KI P | 2006 | J Phys Chem A2006，110，4： | 1 |
| 8 | The association of metabolic syndrome with adipose tissue hormones and insulin resistance in patients with COPD without co- morbidities显示文摘 | Minas M Kostikas K Papaioannou AI Mystridou P Karetsi E Georgoulias P Liakos N Pournaras S Gourgoulianis KI | 2011 | COPD2011，8，6： | 1 |
| 9 | Assessment with mechanical barkhausen effect of residual stress in grain oriented polycrystalline 3% Si-Fe sheet显示文摘 | AUGUSTYNIAK MACIAKOWSKI B PIOTROWS KI P | 2012 | Magnetics IEEE Transactions on2012，48，4： | 1 |
| 10 | Wood-derived estrogens: Studies in vitro with breast cancer cell and in vivo introut 显示文摘 | Mellanen P Petnen T Lehtimki J | 1996 | Toxicol Appl Pharmacol1996，136，： | 1 |
| 11 | Multi-scale Modeling of Tensile Behavior of Carbon Nanotube-reinforeed Composites显示文摘 | Tserpes KI Papanikos P Labeas G | 2008 | Theoretical and Applied Fracture Mechanics2008，49，1： | 1 |
| 12 | Determination of platinum and rhodium in dust and plant samples using microwave-assisted sample digestion and ICP-MS显示文摘 | NIEMEL魧M PER魧M魧KI P PIISPANEN J | 2004 | Analytica Chimica Acta2004，，521： | 1 |
| 13 | Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue显示文摘 | Khopde SM Priyadarsini KI Venkatesan P | 1999 | Biophys Chem1999，80，1： | 1 |
| 14 | High-resolution Pre-edge Structure in the Inner-shell Ionization Threshold Region of Rare Gases Xe, Kr, and Ar显示文摘 | Kivim|ki A Nommiste E | 1996 | Phys Rev1996，54，： | 1 |
| 15 | Swimming stress in DN14-3-3 mice triggers maladaptive cardiac remodeling:role of p38 MAPK显示文摘 | Prakash P Watanabe K Hirabayashi KI | 2007 | Am J Physiol Heart Circ Physiol2007，292，3： | 1 |
| 16 | Elevated cystatin C concentration and pro- gression to prediabetes: The Western New York Study显示文摘 | Donahue R P Stranges S Rejman K Rafalson L B Dmochows- ki J Trevisan M | 2007 | Diabetes Care2007，30，： | 1 |
| 17 | Interaction between protein,phytate,and microbial phytase in vitro studies显示文摘 | KIES A de JONGE L KEMME P | 2006 | J Agric Food Chem2006，54，5： | 1 |
| 18 | Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in male显示文摘 | Remmers DE Wang P Cioffi WG Bland KI | 1997 | Am J Physiol1997，273，62： | 1 |
| 19 | Duration of aortic cross-clamping during elective open abdominal aortic aneurysm repair opera-tions and postoperative cardiac/renal function显示文摘 | Georgakis P Paraskevas KI Bessias N | 2010 | Int Angiology2010，29，3： | 1 |
| 20 | Hydrolytic stability of nucleoside phosphotriesters derived from bis(hydroxymethyl) -1,3-dicarbonyl compounds and their congeners:towards a novel pro-drug strategy for antisense oligonucleotides显示文摘 | Esa Mki Pivi Poijrvi | 2001 | J Chem Soc:Perkin Trans 22001，，： | 1 |
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