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| 1 | Generation of insulin-producing β-like cells from human iPS cells in a defined and completely xeno-free culture system显示文摘因为他们的区别能力,人的导致的 pluripotent 茎(臀部) 细胞为生产胰岛素的胰腺的细胞的产生被认为潜在的来源。在这研究,我们开发了一个五步的 xeno 免费的文化系统高效地在 vitro 区分臀部房间进生产胰岛素的房间。我们发现高少量集中为明确地首先导致区别进胰腺、十二指肠的 homeobox-1 (PDX1 ) 是关键的积极胰腺的祖先然后进 neurogenin 3 (NGN3 ) 表示胰腺的内分泌的祖先,当压制区别进肝或肠的房间时。我们也发现 3-isobutyl-1-methylxanthine (IBMX ) 的联合, exendin-4,和菸碱为进胰岛素的区别是重要的表示了各种各样的胰腺的房间标记的单人赛积极的房间。最尤其是,区分的房间包含了响应各种各样的胰岛素促泌素和葡萄糖的高水平被释放的内长的 C 肽水池。因此,我们的结果表明在 xeno 免费的条件下面产生导出臀部的胰腺的房间的可行性并且加亮他们的潜力与类型 1 糖尿病对待病人。 | Hussain Md. Shahjalal Nobuaki Shiraki Daisuke Sakano Kazuhide Kikawa Soichiro Ogaki Hideo Baba Kazuhiko Kume Shoen Kume | 2014 | Journal of Molecular Cell Biology2014，8，5： | 6 |
| 2 | Autosomal dominant cone-rod dystrophy associated with mutations in codon 244 (Asn244His) and codon 184 (Tyr184Ser) of the peripherin/RDS gene显示文摘 | Kikawa E Chida Y | 1996 | Arch Ophthalmol1996，114，1： | 1 |
| 3 | Follicular dendritic cell sarcoma: ultrastmctural and immunohistochemical studies 显示文摘 | Toyoda K Taniguchi J Kikawa K | 2000 | Intern Med2000，39，11： | 1 |
| 4 | Formation of Chloroform in Gel Filtration Fractions of Vegetable Extracts on Treatment with Sodium Hypochlorite 显示文摘 | Hidaka T Kirigaya T Kikawa H | 1994 | Food Hyg Soc Jpn1994，35，4： | 1 |
| 5 | Angiosarcoma of the Breast - Specific Findings of MRI显示文摘 | Yuichiro Kikawa Yutaka Konishi Yoshihiko Naka-moto | 2006 | Breast Cancer2006，13，4： | 1 |
| 6 | Identification of genetic mutations in Japanese patients with fructose-l, 6-bisphosphatase deflciency显示文摘 | Kikawa Y Inuzuka M Jin BY | 1997 | Am J Hum Gertet1997，61，4： | 1 |
| 7 | Competitive oxidation of 1- and 2-propanol catalyzed by titanium silicalite-1 and the application for selective oxidation of 1-methoxy-2-propanol to 1-methoxy-2-propanone显示文摘 | Hayashi H Kikawa K Mumi Y Shigemoto N SugiyamaS Kawashioro K | 1996 | Catal Lett1996，36，12： | 1 |
| 8 | Key roles for GRB2 - associated - binding protein 1, phos- phatidylinositol - 3 - kinase, cyclooxygenase 2, prostaglan- din E2 and transforming growth factor alpha in linoleic acid- induced upregulation of lung and breast cancer cell growth 显示文摘 | MOURADIAN M KIKAWA K D JOHNSON E D | 2014 | Prostaglandins Leukot Essent Fatty Acids2014，90，4： | 1 |
| 9 | Key roles for GRB2-associated-binding protein 1,phosphatidylinositol-3-kinase,cyelooxygenase 2,prostaglandin E2 and transforming growth factor alpha in linoleic acid-indueed upregulation of lung and breast cancer cell growth显示文摘 | Mouradian M Kikawa KD Johnson ED | 2014 | Prostaglandins Leukot Essent Fatty Acids2014，90，： | 1 |
| 10 | Pediction of non -responsiveness to intravenous high-dose r-globulin therapy in patients with Kawasaki disease at onse显示文摘 | Fukunisbi M Kikawa M Hamana K | 2000 | J Pediatr2000，137，： | 1 |
| 11 | Competitive oxidation of 1-and 2-propanol catalyzed by titanium silicalite-1 and the application for selection oxidation of 1-methoxy-2-propanol to 1-methoxy-2-propanone显示文摘 | HAYASHI H KIKAWA K MURAI Y | 1996 | Catal Lett1996，36，12： | 1 |
| 12 | Positive correlation between inhibitors of matrix metalloproteinase in maliganat ovarian tumor tissure显示文摘 | Kikawa F Amakoshi K Nawa A | 1997 | Canncer Lett1997，120，1： | 1 |
| 13 | Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies 显示文摘 | Toyoda K Taniguchi J Kikawa K | 2000 | Intern Med2000，39，11： | 1 |
| 14 | Intravenous glycerol therapy should not be used in patients with unrecognized fructose- 1,6-bisphosphatase deficiency 显示文摘 | Hasegawa Y Kikawa Y Miyamaoto J | 2003 | Pediatr Int2003，45，1： | 1 |
| 15 | Diagnosis of fructose-1, 6-bisphosphatase deficiency using cultured lymphocyte fraction: a secure and noninvasive alternative to liver biopsy 显示文摘 | Kikawa Y Shin Y S Inuzuka M | 2002 | J Inherit Metab Dis2002，，： | 1 |
| 16 | Detection of human papillomaviruses from Histologieally normal lymph nodes of Japanese cervical cancer patients by nested polymerase chain-reaction assay显示文摘 | Nawa A Nishiyama Y Kikawa F | 1993 | Int J Cancer1993，53，7： | 1 |
| 17 | CONTROL OF THE II-VI/GAAS INTERFACE REACTION USING HYDROGEN RADICAL AND ZN/AS FLUXES显示文摘 | A Taike M Kawata T kikawa | | 0，，： | 1 |
| 18 | Seven tumor markers in benign and malignant germ cell tumors of the ovary 显示文摘 | Kawai M Kano T Kikawa F | 1992 | Gynecol Oncol1992，45，3： | 1 |
| 19 | Biosynthesis of hetero-poly-saccharides by Pestalotiopsis microspore from various monosaccharides as carbon source显示文摘 | Kai A Kikawa M Hatanaka K | 2003 | Carbohydrate Polymers2003，54，： | 1 |
| 20 | Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines 显示文摘 | ROMANOWSKA M KIKAWA K D FIELDS J R | 2007 | Lung cancer2007，55，： | 1 |
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