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| 1 | Following a TRAIL: Update on a ligand and its five receptors显示文摘Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves. | Fiona C. KIMBERLEY Gavin R. SCREATON | 2004 | Cell Research2004，14，5： | 26 |
| 2 | 高校图书馆的工作性质正在变化显示文摘对1973年至1998年间在College&Researeh Libraries News上发布的220价招聘广告所作的内容分析表明,到1998年时,所有高校图书馆职位在日常工作中都要用到计算机技术,教学已经成为参考工作不可分割的一部分,行为技能、尤其是口头和书面交流的技能已成为新的职业要求。作为高校图书馆员所需的专业学位,由美国图书馆协会认可(ALA—accredited)的图书馆学情报学硕士仍被广泛接受。 | BeverlyP.Lynch Kimberley Robles Smith 苏扬 | 2003 | 大学图书馆学报2003，21，1： | 24 |
| 3 | 1971~1997年香港城市代谢的上升趋势显示文摘城市代谢是一个城市对其自然环境负荷的定量描述。1971年,Newcombe等对香港的城市代谢进行了开创性的研究,我们在此基础上,对资源消耗和废弃物再生利用进行了更进一步的深入研究。从20世纪70年代早期开始,香港的人均粮食、水和物质消耗已经以惊人的速度分别增长了20%,40%和149%。在物质财富不断增长的同时,巨大的污染也随之而来,废气总排放量、CO_2浓度、城市固体废弃物以及污水排放也分别增长了30%、250%、245%和153%,因此出现了一系列土地、大气和水系统超负荷的问题。尽管一些旨在治理退化环境的措施已经取得了成功,但是,政府为香港制定的目标是在21世纪成为'一个真正可持续发展的城市',如果要达到这一目标,我们还需要在大众消费行为和政府政策方面进行重大和深远的改进。 | Kimberley Warren-Rhodes Albert Koenig 何永涛 | 2001 | AMBIO-人类环境杂志2001，30，7： | 16 |
| 4 | Photoreceptor-Mediated Bending towards UV-B in Arabidopsis显示文摘植物使适应他们向光的生长是知道优化光合的轻 capturea 过程向光性。Phototropinsare 为向蓝色的 phototropic 生长必要、紫外的光敏电阻器 -- 一(紫外 A ) 光。这里,我们在变白的 Arabidopsis 幼苗向 UV-B 详细说明 phototropicresponse。我们报导早微分的生长被 phototropins 调停,但是清除在 phot1 phot2 向 UV-B ismaintained 弯曲的 phototropic 两倍异种。我们进一步证明对 UV-B 的这 phototropin 独立的 phototropic 回答要求 UV-B photoreceptorUVR8。植物生长素应答的基因的宽广 UV-B-mediated 压抑建议 UVR8 调整由 affectingauxin 发信号的方向性的弯曲。UVR8 依赖的方向性的弯曲比 phototropin response.We 晚发生的运动分析表演断定植物可以使用日光的完整的短波长的光谱到高效地使适应光合的 tissuewith 到来的 light.Key 词: | Filip Vandenbussche Kimberley Tilbrook Ana Carolina Fierro Kathleen Marchal Dirk Poelman Dominique Van Der Straeten Roman UIm | 2014 | Molecular Plant2014，7，6： | 7 |
| 5 | Dynamics of phosphorus in sediments of a naturally acidic lake显示文摘The mechanisms which controls the fixation and/or release of P in sediment of an extremely acidic lake(pH = 2.0 to 3.0) and its response to the influence of eutrophic urban waste water were investigated.The results,in the chemical composition,in the mineralogy of the sediment and in the material as obtained from sediment traps,show that the lake sediments are mainly volcanic material reflecting volcanic features of the basin.The sedimentation rate calculated for the lake(2.5×10^(-2) mg m^(-2) day^(-1)) was higher than that observed in other similar glacial lakes in both Andean Patagonia and also elsewhere in the world.The Total Phosphorus concentration in sediments was higher than figures reported by other authors for mining acid lakes,and the main fraction of P was found associated with organic matter.There was no control by Fe or Al on P,because both are in solution at pH < 3.0.It was concluded that changes in the natural input of nutrients(derivatives of Copahue volcano fluid,the discharge of sewage,or basin run-off) are responsible for a high concentration of SRP and N-NH_4^+ in the lake.Laboratory experiments showed that sediments have no ability to retain phosphorus and a continuous release of P from the sediments into the water column was observed.The assays where the pH was artificially increased showed that the P still remains in solution until at least pH 7.0.It was concluded that changes in the natural input of nutrients due to:1) the volcanic fluids,2) the increase in sewage charges,or 3) surface runoff upstream,maintain a high trophic state with high concentrations of dissolved P and N-NH_4^+,although the threshold of neutral pH in the lake is exceeded.This study will enable a better understanding about of the mechanism of release/fixation of phosphorus in acidic sediments in order to assist in making decisions regarding the conservation and management of this natural environment. | Temporetti PEDRO Snodgrass KIMBERLEY Pedrozo FERNANDO | 2013 | International Journal of Sediment Research2013，28，1： | 6 |
| 6 | 污水灌溉对林地土壤中磷的数量与形态影响显示文摘为避免城市生活污水携带的N、P进入水体,新西兰罗托鲁阿市处理后的污水直接喷灌至Whakarewarewa森林,同时建立污水灌溉林地处理系统长期定位试验地,以评价林地生态系统对污水携带营养物质的同化能力。为了解长期污水灌溉对土壤中P的数量、形态、环境的影响,对该灌溉系统中的土壤进行了剖面采样分析。结果表明:土壤TP(全磷)、Olsen P、M3P(Mehlich-3 P)在所有灌溉区的表层土壤(0~10 cm)均有显著(p<0.05)增加,部分指标的显著增加达深层土壤。随灌溉进入土壤的P大多被保存在上层土壤(0~40 cm)中。土壤中各形态的磷所占比例因长期污水灌溉而改变,灌溉前占优势的NaOH Po(以NaOH浸提得到的有机磷)经长期灌溉后被NaOH Pi(以NaOH浸提得到的无机磷)所取代,上层土壤WSP(水溶性磷,Wa-ter-soluble P)变化明显。以Olsen P 60 mg kg-1和M3P 150 mg kg-1为环境临界值可预测土壤剖面中P的淋失危机,WSP可望成为适用更广的土壤P淋失环境危机预测指标。 | 胡慧蓉 王海龙 Katie Beecroft Mark Kimberley | 2012 | 土壤学报2012，49，3： | 5 |
| 7 | Effects of insulin and pathway inhibitors on the PI3K-Akt- mTOR phosphorylation profile in acute myeloid leukemia cells显示文摘The phosphatidylinositol 3-kinase(PI3K)-Akt-mechanistic target of rapamycin(mTOR)pathway is constitutively activated in human acute myeloid leukemia(AML)cells and is regarded as a possible therapeutic target.Insulin is an agonist of this pathway and a growth factor for AML cells.We characterized the effect of insulin on the phosphorylation of 10 mediators in the main track of the PI3K-Akt-mTOR pathway in AML cells from 76 consecutive patients.The overall results showed that insulin significantly increased the phosphorylation of all investigated mediators.However,insulin effects on the pathway activation profile varied among patients,and increased phosphorylation in all mediators was observed only in a minority of patients;in other patients,insulin had divergent effects.Global gene expression profiling and proteomic/phosphoproteomic comparisons suggested that AML cells from these two patient subsets differed with regard to AML cell differentiation,transcriptional regulation,RNA metabolism,and cellular metabolism.Strong insulin-induced phosphorylation was associated with weakened antiproliferative effects of metabolic inhibitors.PI3K,Akt,and mTOR inhibitors also caused divergent effects on the overall pathway phosphorylation profile in the presence of insulin,although PI3K and Akt inhibition caused a general reduction in Akt pT308 and 4EBP1 pT36/pT45 phosphorylation.For Akt inhibition,the phosphorylation of upstream mediators was generally increased or unaltered.In contrast,mTOR inhibition reduced mTOR pS2448 and S6 pS244 phosphorylation but increased Akt pT308 phosphorylation.In conclusion,the effects of both insulin and PI3K-Akt-mTOR inhibitors differ between AML patient subsets,and differences in insulin responsiveness are associated with differential susceptibility to metabolic targeting. | Ina Nepstad Kimberley Joanne Hatfield Ida Sofie Grønningsæter Elise Aasebø Maria Hernandez-Valladares Karen Marie Hagen Kristin Paulsen Rye Frode SBerven Frode Selheim Håkon Reikvam Øystein Bruserud | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 8 | The effect of acute aerobic exercise on central arterial stiffness,wave reflections,and hemodynamics in adults with diabetes:A randomized cross-over design显示文摘Background:Individuals with diabetes have greater central arterial stiffness,wave reflections,and hemodynamics,all of which promote the accelerated cardiovascular pathology seen in this population.Acute aerobic exercise has been shown to be an effective strategy for reducing central arterial stiffness,wave reflections,and hemodynamics in healthy individuals;however,the effects of acute aerobic exercise in reducing these outcomes is not well established in people with diabetes.Recently,implementation of high-intensity interval exercise(HIIE)has shown superior improvements in cardiovascular health outcomes when compared to traditional aerobic exercise.Yet,the effect of HIIE on the aforementioned outcomes in people with diabetes is not known.The purpose of this study was to(i)describe the central arterial stiffness,wave reflections,and hemodynamic responses to a bout of HIIE and moderate-intensity continuous exercise(MICE)in adults with diabetes;and(ii)compare the effects of HIIE and MICE on the aforementioned outcomes.Methods:A total of 24 adult men and women(aged 29-59 years old)with type 1(n=12)and type 2(n=12)diabetes participated in a randomized cross-over study.All participants completed the following protocols:(i)HIIE:cycling for 4×4 min at 85%-95%of heart rate peak(HR_(peak)),interspersed with 3 min of active recovery at 60%-70%HR_(peak);(ii)MICE:33 min of continuous cycling at 60%-70%HR_(peak);and(iii)control(CON):lying quietly in a supine position for 30 min.Results:A significant group￡time effect was found for changes in central systolic blood pressure(F=3.20,p=0.01)with a transient reduction for the HIIE group but not for the MICE or CON groups.There was a significant group￡time effect for changes in augmentation index at a heart rate of 75 beats/min(F=2.32,p=0.04)with a decrease following for HIIE and MICE but not for CON.For all other measures of central arterial stiffness and hemodynamics,no significant changes were observed(p>0.05).Conclusion:A bout of HIIE appears to lead to a greater transient reduction in central systolic blood pressure than the reduction observed following MICE;however,both HIIE and MICE improved augmentation index at a heart rate of 75 beats/min in people with diabetes.There was no significant difference in response to HIIE and MICE in all outcomes.This provides preliminary evidence on the role of HIIE on such outcomes in people with diabetes. | Kimberley L.Way Angela S.Lee Stephen M.Twigg Nathan A.Johnson | 2021 | Journal of Sport and Health Science2021，10，4： | 4 |
| 9 | Functional relationship between ammonia-oxidizing bacteria and ammonia-oxidizing archaea populations in the secondary treatment system of a full-scale municipal wastewater treatment plant显示文摘The abundance of ammonia-oxidizing bacteria and archaea and their amo A genes from the aerobic activated sludge tanks,recycled sludge and anaerobic digesters of a full-scale wastewater treatment plant(WWTP)was determined.Polymerase chain reaction and denaturing gradient gel electrophoresis were used to generate diversity profiles,which showed that each population had a consistent profile although the abundance of individual members varied.In the aerobic tanks,the ammonia-oxidizing bacterial(AOB)population was more than 350 times more abundant than the ammonia-oxidizing archaeal(AOA)population,however in the digesters,the AOA population was more than 10 times more abundant.Measuring the activity of the amo A gene expression of the two populations using RT-PCR also showed that the AOA amo A gene was more active in the digesters than in the activated sludge tanks.Using batch reactors and dd PCR,amo A activity could be measured and it was found that when the AOB amo A activity was inhibited in the anoxic reactors,the expression of the AOA amo A gene increased fourfold.This suggests that these two populations may have a cooperative relationship for the oxidation of ammonia. | Golam MIslam Peter Vi Kimberley Ann Gilbride | 2019 | Journal of Environmental Sciences2019，31，12： | 4 |
| 10 | Effect of dietary fiber and threonine content on intestinal barrier function in pigs challenged with either systemic E.coli lipopolysaccharide or enteric Salmonella Typhimurium显示文摘Background:The independent and interactive effects of dietary fiber(DF)and threonine(Thr)were investigated in growing pigs challenged with either systemic E.coli lipopolysaccharide(LPS)or enteric Salmonella Typhimurium(ST)to characterise their effect on intestinal barrier function.Results:In experiment 1,intestinal barrier function was assessed via oral lactulose and mannitol(L:M)gavage and fecal mucin analysis in pigs challenged with E.coli LPS and fed low fiber(LF)or high fiber(HF)diets with graded dietary Thr.Urinary lactulose recovery and L:M ratio increased(P<0.05)during the LPS inoculation period in LF fed pigs but not in HF fed pigs.Fecal mucin output was increased(P<0.05)in pigs fed HF compared to LF fed pigs.In experiment 2,RT-qPCR,ileal morphology,digesta volatile fatty acid(VFA)content,and fecal mucin output were measured in Salmonella Typhimurium challenged pigs,fed LF or HF diets with standard or supplemented dietary Thr.Salmonella inoculation increased(P<0.05)fecal mucin output compared to the unchallenged period.Supplemental Thr increased fecal mucin output in the HF-fed pigs(Fib×Thr;P<0.05).Feeding HF increased(P<0.05)VFA concentration in cecum and colon.No effect of either Thr or fiber on expression of gene markers was observed except a tendency(P=0.06)for increased MUC2 expression with the HF diet.Feeding HF increased goblet cell numbers(P<0.05).Conclusion:Dietary fiber appears to improve barrier function through increased mucin production capacity(i.e.,goblet cell numbers,MUC2 gene expression)and secretion(i.e.,fecal mucin output).The lack of effect of dietary Thr in Salmonella-challenged pigs provides further evidence that mucin secretion in the gut is conserved and,therefore,Thr may be limiting for growth under conditions of increased mucin production. | Michael O.Wellington Kimberley Hamonic Jack E.C.Krone John K.Htoo Andrew G.Van Kessel Daniel A.Columbus | 2020 | Journal of Animal Science and Biotechnology2020，11，3： | 3 |
| 11 | 长期污水灌溉后林地土壤中磷的含量与移动显示文摘为尽可能地削减污水携带的N、P进入湖泊,处理后的城市生活污水被直接喷灌到新西兰罗托鲁阿市的Whakarewarewa森林,并建立了污水灌溉林地处理系统的长期定位试验地以评价生态系统对污水携带营养物质的同化能力.为查清长期污水灌溉土壤中P的数量、迁移淋失及其环境危机,对11a污水灌溉后火山灰土壤中磷的积累、再分布进行剖面分层采样测定.结果表明,土壤pH、TP、Olsen P、M3P、M3Ca和M3Mg在所有灌溉处理区的表层土壤(0~10 cm)均有显著(p<0.05)增加,部分增加的显著性达到20~40 cm土层或更深层次土壤.大多数随灌溉而进入土壤的P被保存在上层土壤(0~40 cm)中.土壤Olsen P和M3P的浓度在中、高水平处理区的20 cm以上土层中超过了环境临界值(Olsen P为60 mg.kg-1;M3P为150mg.kg-1),磷饱和率(M3PSR)数值同时显示表层土壤对P的吸持已近饱和,预示土壤磷素有随下渗水向下移动的潜在可能.常规土壤采样以60 mg.kg-1 Olsen P测定值为环境临界值,可解决土壤剖面中磷的下移监测难题.以M3P与M3Al、M3Fe的摩尔比计算的磷饱和率(M3PSR)作为长期污水灌溉林地处理系统中土壤磷向下移动的环境危机临界值参数指标已不是很理想,对新的磷饱和参数的研究是今后的主要工作之一. | 胡慧蓉 王海龙 Mark Kimberley | 2010 | 环境科学2010，31，8： | 3 |
| 12 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 13 | Hepatic stellate cells in liver development, regeneration, and cancer显示文摘 | Yin Chunyue Evason Kimberley J Asahina Kinji Stainier Didier Y R | 2013 | Journal of Clinical Investigation2013，，5： | 3 |
| 14 | Distal triceps injuries(including snapping triceps):A systematic review of the literature显示文摘AIM To review current literature on types of distal triceps injuryand determine diagnosis and appropriate management.METHODS We performed a systematic review in PubM ed, Cochrane and EMBASE using the terms distal triceps tears and snapping triceps on the 10 th January 2017. We excluded all animal, review, foreign language and repeat papers. We reviewed all papers for relevance and of the papers left we were able to establish the types of distal triceps injury, how these injuries are diagnosed and investigated and the types of management of these injuries including surgical. The results are then presented in a review paper format.RESULTS Three hundred and seventy-nine papers were identified of which 65 were relevant to distal triceps injuries. After exclusion we had 47 appropriate papers. The papers highlighted 2 main distal triceps injuries: Distal triceps tears and snapping triceps. Triceps tear are more common in males than females occurring in the 4th-5th decade of life and often due to a direct trauma but are also strongly associated with weightlifting and American football. The tears are diagnosed by history and clinically with a palpable gap. Diagnosis can be confirmed with the use of ultrasound(US) and magnetic resonance imaging. Treatment depends on type of tear. Partial tears can be treated conservatively with bracing and physio whereas acute tears need repair either open or arthroscopic using suture anchor or bone tunnel techniques with similar success. Chronic tears often need augmenting with tendon allograft or autograft. Snapping triceps are also seen more in men than women but at a mean age of 32 years. They are characterized by a snapping sensation mostly medially and can be associated with ulna nerve subluxation and ulna nerve symptoms. US is the diagnostic modality of choice due to its dynamic nature and to differentiate between snapping triceps tendon or ulna nerve. Treatment is conservative initially with activity avoidance and if that fails surgical management includes resection of triceps edge or transposition of the tendon plus or minusulna nerve transposition.CONCLUSION Distal triceps injuries are uncommon. This systematic review examines the evidence base behind diagnosis, imaging and treatment options of distal triceps injuries including tears and snapping triceps. | Kimberley Shuttlewood James Beazley Christopher D Smith | 2017 | World Journal of Orthopedics2017，8，6： | 2 |
| 15 | Assessing the longitudinal associations and stability of smoking and depression syndrome over a 4‐year period in a community sample with type 2 diabetes 在一个社区2型糖尿病样本中进行的为期4年的吸烟与抑郁综合征之间的纵向相关性以及稳定性的评估显示文摘 | Matthew Clyde Kimberley J. Smith Geneviève Gariépy Norbert Schmitz | 2015 | Journal of Diabetes2015，，： | 2 |
| 16 | Impact and risk factors of post-stroke bone fracture显示文摘Bone fracture occurs in stroke patients at different times during the recovery phase, prolonging recovery time and increasing medical costs. In this review, we discuss the potential risk factors for post-stroke bone fracture and preventive methods. Most post-stroke bone fractures occur in the lower extremities, indicating fragile bones are a risk factor. Motor changes, including posture, mobility, and balance post-stroke contribute to bone loss and thus increase risk of bone fracture. Bone mineral density is a useful indicator for bone resorption, useful to identify patients at risk of post-stroke bone fracture. Calcium supplementation was previously regarded as a useful treatment during physical rehabilitation. However, recent data suggests calcium supplementation has a negative impact on atherosclerotic conditions. Vitamin D intake may prevent osteoporosis and fractures in patients with stroke. Although drugs such as teriparatide show some benefits in preventing osteoporosis, additional clinical trials are needed to determine the most effective conditions for post-stroke applications. | Kang Huo Syed I Hashim Kimberley LY Yong Hua Su Qiu-Min Qu | 2016 | World Journal of Experimental Medicine2016，6，1： | 2 |
| 17 | Primary renal carcinoid tumor with liver metastases detected with somatostatin receptor imaging显示文摘 | Patrick Mufarrij Ioannis M. Varkarakis Kimberley D. Studeman Thomas W. Jarrett | 2005 | Urology2005，，： | 2 |
| 18 | Analysis of f-MRI and finger tracking training in subjects with chronic stroke显示文摘 | Kimberley TJ Lewis SM Auerbach EJ | 2002 | Brain2002，125，4： | 1 |
| 19 | APRIL in B-cellmalignancies and autoimmunity 显示文摘 | Kimberley FC Medema JP Hahne M | 2009 | Results Probl CellDiffer2009，49，： | 1 |
| 20 | Citizen Involvement and Performance Management in Special-Purpose Governments显示文摘 | Tanya Heikkila&Kimberley Roussin Lsett | 2007 | Public Administration Review2007，，2： | 1 |
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