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94篇 您的检索式：作者名="Kircheis R"

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	题名	作者	年代	出处	被引量
1	Voxel-based analyses of magnetization transfer imaging of the brain in hepatic encephalopathy显示文摘AIM: To evaluate the spatial distribution of cerebral abnormalities in cirrhotic subjects with and without hepatic encephalopathy (HE) found with magnetization transfer imaging (MTI).METHODS: Nineteen cirrhotic patients graded from neurologically normal to HE grade 2 and 18 healthy control subjects underwent magnetic resonance imaging. They gave institutional-review-board-approved written consent. Magnetization transfer ratio (MTR) maps were generated from MTI. We tested for significant differences compared to the control group using statistical non-parametric mapping (SnPM) for a voxelbased evaluation.RESULTS: The MTR of grey and white matter was lower in subjects with more severe HE. Changes were found in patients with cirrhosis without neurological defi cits in the basal ganglia and bilateral white matter. The loss in magnetization transfer increased in severity and spatial extent in patients with overt HE. Patients with HE grade 2 showed an MTR decrease in white and grey matter: the maximum loss of magnetization transfer effect was located in the basal ganglia [SnPM (pseudo-)t = 17.98, P = 0.0001].CONCLUSION: The distribution of MTR changes in HE points to an early involvement of basal ganglia and white matter in HE.	Falk R Miese Hans-Jrg Wittsack Gerald Kircheis Arne Holstein Christian Mathys Ulrich Mdder Mathias Cohnen	2009	World Journal of Gastroenterology2009，15，41：	2
2	Ernst Wagner Design and gene delivery activity of modified polyethylenimines显示文摘	Wightman L	2001	Adv Drug Deliv Rev2001，53，3：	1
3	Design and gene delivery activity of modified polyethylenimines 显示文摘	KIRCHEIS R WIGHTMAN L WAGNER E	2001	Adv Drug Deliv Rev2001，53，3：	1
4	polycation-based DNA complexes for tumor-targeted gene delivery in vivo 显示文摘	Kircheis R Schuller S Brunner S	1999	J Gene Med1999，1，2：	1
5	Therapeutic efficacy of L-ornithine- L-aspartate infusions in patients with cirrhosis and hepatic encephalopathy: results of a placebo-conltolled, double blind study 显示文摘	Kircheis G Nilins R Held C	1997	Hepatology1997，25，6：	1
6	Design and gene delivery activity of modified polyethylenimines 显示文摘	KIRCHEIS R WIGHTMAN L WAGNER E	2001	Ad- vanced Drug Delivery Reviews2001，53，：	1
7	Design and gene delivery activity of modified polyethylenimines显示文摘	WIGHTMAN L WAGNER E	2001	Adv Drug Deliv Rev2001，53，3：	1
8	Hepatic Encephalopathy in Chronic Liver Disease:a Clinical Manifestation of Astrocyte Swelling and Low grade Cerebral Edema显示文摘	Haussinger D Kircheis G Fischer R	2000	J Hepatol2000，32，6：	1
9	Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo 显示文摘	Kircheis R Rssler V	2001	J Gene Med2001，3，4：	1
10	Design and gene delivery activity of modified polyethylenimines显示文摘	Kircheis R Wightman L Wagner E	2001	Adv Drug Deliv Rev2001，53，3：	1
11	Tumor targeting with surfaceshielded ligand-polycation DNA complexes显示文摘	Kircheis R Blessing T Brunner S	2001	J Control Release2001，72，13：	1
12	Nonviral gene transfer into fetal mouse livers( a comparison between the cationic polymer PEI and naked DNA) 显示文摘	Gharwan H Wightman L Kircheis R	2003	Gene Ther2003，10，：	1
13	Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo显示文摘	Wightman L Kircheis R Rossler V	2001	J Gene Med2001，3，4：	1
14	Tumor-targeted gene delivery: an attractive strategy to use highly active effector molecules in cancer treatment 显示文摘	Kircheis R Wightman L Kursa M	2002	Gene Ther2002，9，：	1
15	Design and gene delivery activity of modified polyethylenimines 显示文摘	Kircheis R Wightman L Wagner E	2001	Advanced Drug Delivery Reviews2001，53，：	1
16	polyethylenimine /DNA complexes shielder by transperrin target gene expression to tumors after system application显示文摘	Kircheis R Wightman L Schreiber	2001	Gene Ther2001，8，1：	1
17	Immunogenicity of thera-peutics: a matter of efficacy and safety 显示文摘	NECHANSKY A KIRCHEIS R	2010	Expert Opin Drug Discov2010，5，11：	1
18	Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application 显示文摘	Kircheis R Wightman L Schreiber A	2001	Gene Ther2001，8，：	1
19	Nonviral gene transfer into fetal mouse livers (a comparison between the cationic polymer PEI and naked DNA)显示文摘	Gharwan H Wightman L Kircheis R	2003	Gene Ther2003，10，：	1
20	Design and gene delivery activlty of modified polyethylenimines 显示文摘	Kircheis R Wighwnan L Wagner E	2001	Adv Drug Deliv Rev2001，53，3：	1

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