|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | COSMO: A new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient 显示文摘 | Klamt A SchiiiLrmann G | 1993 | Chem Soc Perkin Trans1993，2，2： | 1 |
| 3 | Hemodynamic effects of the combination of exmedetomidine fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass 显示文摘 | Klamt JG Vicente WV Garcia LV | 2010 | Rev Bras Anestesiol2010，60，4： | 1 |
| 4 | Structural and functional analysis of cellular networks with CellNetAna- lyzer 显示文摘 | Klamt S Saez-Rodriguez J Gilles ED | 2007 | BMC Syst Biol2007，1，1： | 1 |
| 5 | COSMO: A new approach to dielectric screening in solvents with explicit expressions for the screening energy and its gradient显示文摘 | Klamt A Schuurmann G | 1993 | J Chem Soc Perkin Trans1993，2，5： | 1 |
| 6 | CASOP: A computational ap- proach for strain optimization aiming at high productivity 显示文摘 | Hidicke O Klamt S | 2010 | J Biotechnol2010，147，： | 1 |
| 7 | “Conductor-like screening model for real solvents:A new approach to the quantitative calculation of solvation phenomena”显示文摘 | Klamt A | | 0，，7： | 1 |
| 8 | Incorporation of solvent effects into the density functional calculations of molecular energies and geometries 显示文摘 | Andzelm J Klamt A | 1995 | Chem Phys1995，103，5： | 1 |
| 9 | Effects of intrathecal sufentanil on plasma oxytocin and cortisol concentrations in women during the first stage of labor显示文摘 | STOCCHE R M KLAMT J G ANTUNES-RODRIGUES J | 2001 | Reg Anesth Pain Med2001，26，6： | 1 |
| 10 | CASOP:A computational approach for strain ptimization aiming at high productivity 显示文摘 | Hadicke O Klamt S | 2010 | J Biotech2010，147，2： | 1 |
| 11 | Effects of dexmedetomide fentanyl infusion on blood pressure and heart rate during cardiac surgery in children显示文摘 | KLAMT J G ANDRADE VICENTE W V GARCIA L V | | 0，，08： | 1 |
| 12 | Intravenous regional block is similar to sympathetic ganglion block for pain man agement in patients with complex regional pain syndrome type I显示文摘 | Nascimento MS Klamt JG Prado WA | 2010 | Braz J Med Biol Res2010，43，12： | 1 |
| 13 | Use of network analysis of metabolic systems in bioengineering 显示文摘 | Schuster S Klamt S Weckwerth W | 2002 | Bioprocess Biosys Eng2002，24，： | 1 |
| 14 | Analgesic and adverse effects of a low dose of intrathecally administered hyperbaric neostigmine alone or combined with morphine in patients submitted to spinal anaesthesia: pilot studies显示文摘 | Klamt JG Garcia LV Prado WA | 1999 | Anaesthesia1999，54，1： | 1 |
| 15 | Room temperature ionic liquids as replacements for conventional solvents – A review显示文摘 | Kenneth N. Marsh Alex Deev Alex C-T. Wu Emma Tran A. Klamt | 2002 | Korean Journal of Chemical Engineering2002，，3： | 1 |
| 16 | Hemodynamic effects of the combination of dexmedetomidine-fentanyl versus midazolam-fentanyl in children undergoing cardiac surgery with cardiopulmonary bypass显示文摘 | Klamt J G Vicente W V Garcia L V | 2010 | Rev BrasAnestesiol2010，60，1： | 1 |
| 17 | Metabolic network struc- ture determines key aspects of functionality and regulation显示文摘 | Stelling J Klamt S Bettenbrock K | 2002 | Na- ture2002，420，6912： | 1 |
| 18 | Effects of 2 mg ·kg-1 of intavenoua lidocaine on the latency of two different doses of rocurunium and on the hemodynamic response to orotracheal intubation显示文摘 | Vivancos GG Klamt JG Garcia LV | | 0，，01： | 1 |
| 19 | Structural and functional a- nalysis of cellular networks with CellNetAnalyzer显示文摘 | Klamt S Saez-Rodriguez J Gilles E D | 2007 | BMC Syst Bi- ol2007，1，： | 1 |
| 20 | Effects of dexmedetomidine fentanyl infusion on blood pressure and heart rate during cardiac surgery in children 显示文摘 | Klamt JG de Andrade Vicente WV Garcia LV | 2010 | Anesthesiol Res Pract2010，2010，86： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员