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| 1 | Recent trends in liver transplantation for alcoholic liver disease in the United States显示文摘AIM To examine temporal changes in the indications for liver transplantation(LT) and characteristics of patients transplanted for alcoholic liver disease(ALD).METHODS We performed a retrospective cohort analysis of trends in the indication for LT using the United Network for Organ Sharing(UNOS) database between 2002 and 2015. Patients were grouped by etiology of the liver disease and characteristics were compared using χ~2 and t-tests. Time series analysis was used identifying any year with a significant change in the number of transplants per year for ALD, and before and after eras were modeled using a general linear model. Subgroup analysis of recipients with ALD was performed by age group, gender, UNOS region and etiology(alcoholic cirrhosis, alcoholic hepatitis and hepatitis C-alcoholic cirrhosis dual listing).RESULTS Of 74216 liver transplant recipients, ALD(n = 9400, 12.7%) was the third leading indication for transplant after hepatitis C and hepatocellular carcinoma. Transplants for ALD, increased from 12.8%(553) in 2002 to 16.5%(1020) in 2015. Time series analysis indicated a significant increase in the number of transplants per year for ALD in 2013(P = 0.03). There were a stable number of transplants per year between 2002 and 2012(linear coefficient 3, 95%CI:-4.6, 11.2) an increase of 177 per year between 2013 and 2015(95%CI: 119, 234). This increase was significant for all age groups except those 71-83 years old, was observed for both genders, and was incompletely explained by a decrease in transplants for hepatitis C and ALD dual listing. All UNOS regions except region 9 saw an increase in the mean number of transplants per year when comparing eras, and this increase was significant in regions 2, 3, 4, 5, 6, 8, 10 and 11.CONCLUSION There has been a dramatic increase in the number of transplants for ALD starting in 2013. | Catherine E Kling James D Perkins Robert L Carithers Dennis M Donovan Lena Sibulesky | 2017 | World Journal of Hepatology2017，9，36： | 6 |
| 2 | Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma显示文摘 | BELINSKY S A KLINGE D M LIECHTY K C | 2004 | Carcinogenesis2004，25，6： | 1 |
| 3 | Adaptive Changes in the Self-Concept During A Life Transition显示文摘 | Kling K C Ryff C D Essex M J | 1997 | Personality and Social Psy- chology Bulletin1997，23，9： | 1 |
| 4 | Radiolarian vertical distribution patterns across the southern California current显示文摘 | KLING S A BOLTOVSKOY D | 1995 | Deep Sea Res Ⅰ1995，，： | 1 |
| 5 | Resection of a heart tumor using autotransplantation显示文摘 | Nestle HW Kling D | 1988 | Thorac Cardiovasc Surg1988，36，1： | 1 |
| 6 | A universal pricing framework for guaranteed minimum benefits in variable annuities显示文摘 | BAUER D KLING A RUSS J | 2008 | Astin Bulletin2008，38，62： | 1 |
| 7 | GMWB for life an analysis of lifelong withdrawal guarantees显示文摘 | HOLZ D KLING A RUSS J | 2012 | Springer-Verlag2012，101，3： | 1 |
| 8 | Toxic effects of sublethal concentrations of Lebaycid upon the ovaries were examined in Sarother- odon leucostictus 显示文摘 | Kling D B | 1986 | Z Angew Zool1986，73，1： | 1 |
| 9 | Antioxidant protection of phospholipid bilayers by alpha - tocopherol 显示文摘 | Liebler D C Kling D S Reed D J | 1986 | Journal of Biological Chemistry1986，261，12： | 1 |
| 10 | Periodontal indices around natural and titanium abutments: A longitudihal muhicentre study 显示文摘 | van Steenberghe D Klinge B Linden U | 1993 | J Periodontol1993，64，6： | 1 |
| 11 | Periodontalindices around natural and titaniam abutmenu:A longitudi2 nalmulticentre stuay显示文摘 | van Steenberghe D Klinge B Lindén U | 1993 | J Periodontol1993，64，6： | 1 |
| 12 | p16INK4a and beta- catenin alterations in rat liver tumors induced by NNK 显示文摘 | Pulling L C Klinge D M Belinsky S A | 2001 | Carcinogenesis2001，22，3： | 1 |
| 13 | Novel developments in o- mega-3 fatty acid-based strategies显示文摘 | Davidson MH Kling D Maki KC | 2011 | Current Opinion inLipid- ology2011，22，6： | 1 |
| 14 | Promoter hypermethylation of the O^6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression 显示文摘 | PULLING L C DIVINE K K KLINGE D M | 2003 | Cancer Res2003，63，16： | 1 |
| 15 | Mars Dust Counter 显示文摘 | Igenbergs E Klinge D Miyamoto H | 1998 | Earth Planets Space1998，，50： | 1 |
| 16 | Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model 显示文摘 | Lyon C M Klinge D M Do K C | 2009 | Carcinogenesis2009，30，12： | 1 |
| 17 | Correlates of local cerebral blood flow(CBF) in normal pressure hydrocephalus patients before and after shunting A retrospective analysis of H20 PET CBF studies in 65 patients 显示文摘 | Kling PM Brooks D J Samii A | 2008 | Clin Neurol Neurosurg2008，110，4： | 1 |
| 18 | Re- expression of CXCL14, a common target for epigenetic si- lencing in lung cancer, induces tumor necrosis显示文摘 | TESSEMA M KLINGE D M Y1NGLING C M | 2010 | Onco- gene2010，29，37： | 1 |
| 19 | Combining Revealed and StatedPreferences:Consistency Tests and Their Interpretations显示文摘 | AzevedoC D J A Herriges C L Kling | 2003 | AmericanAgricultural Economics Association2003，85，3： | 1 |
| 20 | Antioxidant protection of phospholipid bilayers by α-tocopherol,control of α- tocopherol status by ascorbic acid and glutathione显示文摘 | LIEBLER D C KLING D S REED D J | 1986 | Journal of Biological Chemistry1986，261，12： | 1 |
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