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58篇 您的检索式:作者名="Klonisch"
    题名 作者 年代 出处 被引量
1S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los 2010Cell Research2010,20,3:13
2Cancer stem cell markers in common cancers-therapeutic im- plications显示文摘KLONISCH T WIECHEC E HOMBACH-KLONISCH S 2008Trends Mol Med2008,14,10:1
3The changing face of thyroid cancer in a population-based cohort 显示文摘Pathak KA Leslie WD Klonisch TC 2013Cancer Med2013,2,4:1
4Cancer stem cell markers in common cancers therapeutic implications显示文摘Klonisch T Wiechec E Hombach Klonisch S 2008Trends Mol Med2008,14,10:1
5Molecular and genetic regulation of testis descent and external geni- talia development显示文摘Klonisch T Fowler PA Hombach-Klonisch S 2004Dev Biol2004,270,1:1
6Adult stem cells and their trans - differentiation potential - per- spectives and therapeutic applications 显示文摘HOMBACH KLONISCH S PANIGRAHI S RASHEDI I 2008J Mol Med2008,86,12:1
7Arylhydrocarbon eceptor expression in the human endometrium显示文摘Chenhoff A Seliger G Klonisch T 1999Fetil Steril1999,71,2:1
8Expression of protamine-1 and-2 mRNA during human spermiogenesis显示文摘Steger K Pauls K Klonisch T Franke F E Bergmann M 0,,03:1
9An additive interaction between the NFB and estrogen receptor signalling pathways in human endometrial epithelial cells 显示文摘King A E Collins F Klonisch T 2010Hum Reprod2010,25,:1
10Expression of CD97 and CD55 in human medullary thyroid carcinomas 显示文摘Mustafa T Klonisch T Hombach-Klonisch S 2004Int J Oncol2004,24,2:1
11Interconneetions be- tween apoptotie, autophagic and necrotic pathways: implieations for eaneer therapy development显示文摘Jain M V Paczulla A M Klonisch T 2013J Cell Mol Med2013,17,1:1
12Cancer stem cell markers in common cancers-therapeutic implications显示文摘Klonisch T Wiechec E Hombach-Klonisch S 0,,10:1
13Relaxin enhances the oncogenic ctential of human thyroid carcinoma cells显示文摘Hombach Klonisch S Bjalek J Trojanowicz B 2006Am ] Pathol2006,169,2:1
14Interconneetions between apoptotic, autophagic and necrotic pathways : implications for cancer therapy development显示文摘Jain MV Paczulla AM Klonisch T 2013J Cell Mol Med2013,17,1:1
15Thyroid stem cells and cancer显示文摘Klonisch T Hoang-Vu C Hombach-Klonisch S 2009Thyroid2009,19,12:1
16Interconnections between apoptotic,autophagic and necrotic pathways:implications for cancer therapy development显示文摘Jain MV Paczulla AM Klonisch T 2013J Cell Mol Med2013,17,1:1
17Arylhydroearbon receptor expression in the human endometrium 显示文摘KUCHENHOFF A SELIGER G KLONISCH T 1999Fertil Steril1999,71,2:1
18Cancer stem cell markers in common cancers--therapeutic implications显示文摘Klonisch T Wiechec E Hombach-Klonisch S 2008Trends Mol Med2008,14,10:1
19Expression of CD97 and CD55 in human medullary thyroid carcinomas 显示文摘Murgan J Klonisch T Hombaclr S 2004Int J Oncol2004,24,2:1
20Molecular and genetic regulation of testis descent and extemal genitalia development显示文摘Klonisch T Fowler PA Hombach-Klonich S 0,,01:1
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