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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Neural origins of the P300 显示文摘 | Soltani M Knight R T | 2000 | Crit Rev Neurobiol2000，14，： | 1 |
| 3 | Protection against heat stress-inducedoxidative damage in Arabidopsis involves calcium,abscisic acid,ethylene,and salicylic acid显示文摘 | Larkindale J Knight M R | 2002 | Plant Physiol2002，128，2： | 1 |
| 4 | Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex 显示文摘 | Hamady M Walker JJ Harris JK Gold NJ Knight R | 2008 | Nat Methods2008，5，3： | 1 |
| 5 | Variation in pituitary ex-pression of mRNAs encoding the putative inhibin co-receptor(be-taglycan)and type-I and type-II activin receptors during the chickenovulatory cycle显示文摘 | T M Lovell P G Knight and R T Gladwell | 2005 | Journal of Endocrinology2005，186，3： | 1 |
| 6 | Transgenic plant aequorin reports the effects of touch and cold-shock and elicitors on cytophasmic calcium显示文摘 | KNIGHT M R CAMPBELL A K SMITH S M | 1991 | Nature1991，352，： | 1 |
| 7 | Performance assessment of a nuclear waste repository: Upscaling coupled hydro-mechanical properties for far-field transport analysis 显示文摘 | Blum P Mackay R Riley M S Knight J L | 2005 | International Journal of Rock Mechanics and Mining Sciences2005，42，56： | 1 |
| 8 | Calcium sig- nalling in Arabidopsis thaliana responding to drought and salinity显示文摘 | Knight H Trewavas A J Knight M R | 1997 | The Plant1997，12，： | 1 |
| 9 | Rapid transcriptome changes induced by cytosolic Ca2+ transients reveal ABRErelated sequences as Ca2+-responsive cis elements in Arabidopsis显示文摘 | Kaplan B Davydov O Knight H Galon Y Knight M R Fluhr R Frommc H | | 0，，： | 1 |
| 10 | Sigal transduction leading to low-temperature tolerance in Arabidopsis thaliana显示文摘 | Knight M R | | 0，，： | 1 |
| 11 | Herbicidal activity of cineole derivatives显示文摘 | BARTON A F M DELL B KNIGHT A R | 2010 | Journal of Agricultural and Food Chemistry2010，58，10： | 1 |
| 12 | Movement and habitat use by radio - tagged paddlefish in the upper Mississippi River and tributaries 显示文摘 | ZIGLER S J DEWEY M R KNIGHTS B C | 2003 | North American Journal of Fisheries Management2003，23，1： | 1 |
| 13 | Transgenic Plant aequorin reports the effects of touch and eold-shock and elicitors on cytoplasmic calcium 显示文摘 | Knight M R Campbell A K Smith S M el al | 1991 | Nature1991，352，524： | 1 |
| 14 | Innovativeness: Its antecedents and impact on business performance显示文摘 | Huh G T M Hurley R F Knight G A | 2004 | Industrial Marketing Management2004，33，5： | 1 |
| 15 | Transgenic plant aequorin reports the effects of touch and cold-shock and elicitors on cytoplasmic calcium 显示文摘 | Knight M R Campbell A K Smith S M | 1991 | Nature1991，352，： | 1 |
| 16 | Dynamic shift - share analysis 显示文摘 | BARFF R A KNIGHT M PL | 1988 | Growth and Change1988，19，： | 1 |
| 17 | Microbial community profiling for human microbiome projects:Tools,techniques,and challenges显示文摘 | Hamady M Knight R | 2009 | Genome Research2009，19，7： | 1 |
| 18 | The role of oxidantivestress and reactive oxygen species in acetaminophen hepato-toxichy显示文摘 | Jaeschke H Knight T R Bajt M L | 2003 | Toxicol Lett2003，144，27： | 1 |
| 19 | The study of interg- ranular corrosion in aircraft aluminum alloys using X- ray tomography 显示文摘 | Knight S P Salagaras M Trueman A R | 2011 | Corrosion Science2011，53，2： | 1 |
| 20 | Innovativeness: its antecedents and impact on business performance显示文摘 | HULT G T M HURLEY R F KNIGHT G A | 2004 | Industrial Marketing Management2004，，5： | 1 |
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