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| 1 | Managementofearlyasymptomaticgastrointestinalstromaltumorsofthe stomach显示文摘Gastrointestinal stromal tumors(GIST) are the most common mesenchymal tumors of the digestive tract. Approximately two thirds of clinically manifest tumors occur in the stomach, nearly one third in the small bowel, and the rest in the colorectal region with a few cas-es in the esophagus. GIST originate within the smooth muscle layer in the wall of the tubular gastrointestinal tract and grow mostly toward the serosa, far less often toward the mucosa. In the latter case, ulceration may develop and can cause gastrointestinal bleeding as the cardinal symptom. However, most GIST of the stomach are asymptomatic. They are increasingly detected incidentally as small intramural or submucosal tumors during endoscopy and particularly during endoscopic ultra-sound. Epidemiological and molecular genetic findings suggest that early asymptomatic GIST of the stomach(< 1 cm) show self-limiting tumorigenesis. Thus, early(< 1 cm) asymptomatic gastric GIST(synonym: micro-GIST) are found in 20%-30% of the elderly. The mostlyelderly people with early gastric GIST have an excellent GIST-specific prognosis. Patients with early GIST of the stomach can therefore be managed by endoscopic sur-veillance. | Scherübl H Faiss S Knoefel WT Wardelmann E | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 23 |
| 2 | Surgical strategies in the therapy of non-small cell lung cancer显示文摘Lung cancer represents the leading cause of cancer mortality worldwide. Despite improvements in preoperative staging, surgical techniques, neoadjuvant/adjuvant options and postoperative care, there are still major difficulties in significantly improving survival, especially in locally advanced non-small cell lung cancer(NSCLC). To date, surgical resection is the primary mode of treatment for stage?Ⅰ?and Ⅱ NSCLC and has become an important component of the multimodality therapy of even more advanced disease with a curative intention. In fact, in NSCLC patients with solitary distant metastases, surgical interventions have been discussed in the last years. Accordingly, this review displays the recent surgical strategies implemented in the therapy of NSCLC patients. | Feras Al-Shahrabani Daniel Vallbhmer Sebastian Angenendt Wolfram T Knoefel | 2014 | World Journal of Clinical Oncology2014，5，4： | 10 |
| 3 | Metastasized pancreatic carcinoma with neoadjuvant FOLFIRINOX therapy and R0 resection显示文摘Patients with metastasized carcinoma of the pancreas have a very poor prognosis, and long-term survival cannot be expected. This case report describes two patients with an initial diagnosis of metastatic pancreatic cancer, both with hepatic metastases and one with an additional peritoneal carcinomatosis. Initially, both patients were treated intravenously with the FOLFIRINOX chemotherapy regimen, consisting of 5-FU, folinic acid, irinotecan and oxaliplatin. Surprisingly, the FOLFIRINOX treatment resulted in complete resolution of the hepatic metastases in both patients, with no lesions detectable by computed tomography scan. Furthermore, treatment response included decreased diameter of the primary tumor in the tail of the pancreas and disappearance of the additional peritoneal carcinomatosis. Both patients were discussed by our multidisciplinary tumor board, which recommended surgical resections of the carcinoma. The R0 resection of the primary tumor was successful in both cases and, interestingly, the resected tissues showed no evidence of the hepatic metastases intraoperatively. In the first case, the patient received a postoperative 6-mo course of adjuvant chemotherapy with gemcitabine. In the second case, the patient continued to receive the FOLFIRINOX regimen for an additional 6 mo postoperatively. At 12 mo after the operation, a nonresectable retroperitoneal lymph node metastasis was detected in the first patient, whereas the second patient remained in complete remission at the time of this report(5 mo after the adjuvant therapy was discontinued). This case report is the first of its kind to describe two cases of hepatic metastatic pancreatic carcinoma that were resectable following treatment with FOLFIRINOX. Further studies are required to examine the role of FOLFIRINOX as a neoadjuvant treatment option in subgroups of patients with initially metastasized pancreatic carcinoma. | Sophie Schneitler Patric Krpil Jasmin Riemer Gerald Antoch Wolfram Trudo Knoefel Dieter Hussinger Dirk Graf | 2015 | World Journal of Gastroenterology2015，21，20： | 9 |
| 4 | Intrahepatic endometriosis as differential diagnosis: Case report and literature review显示文摘Intrahepatic endometriosis is one of the rarest forms of atypical endometriosis; only eighteen cases have been reported in the English literature. We describe the case of a 32-year-old woman, who presented with persistent, non-cyclical upper right quadrant abdominal pain, a central liver cyst, and no history of endometriosis. Three years previous, she was diagnosed with an intrahepatic cyst. The lesion progressed and two laparoscopic deroofing-operations were performed, yet the diagnosis of intrahepatic endometriosis was never reached. She presented in our clinic with further progress of the cyst as well as obstruction of the intrahepatic biliary system. The magnetic resonance imaging showed a 9.5 cm × 12 cm, lobulated intrahepatic cyst. We performed an ultrasonic pericystectomy. Immunostaining confirmed intrahepatic endometriosis. Only one of the previously described eighteen patients with intrahepatic endometriosis presented with cyclical pain in the upper right abdominal quadrant accompanying menstruation. This lack of a 'typical' clinic makes it challenging to diagnose extragonadal endometriosis without histopathology. A previous history of endometriosis was described in only twelve cases, thus the diagnosis of this condition should not be limited to patients with a known history of endometriosis. Six of 18 patients were postmenopausal, demonstrating this condition is not limited to women of reproductive age. A preoperative diagnosis was only reached in seven of the previously described cases, highlighting the importance of preoperative biopsies. Yet due to the potential adverse effects, a transhepatic biopsy must be discussed individually. Although rare, intrahepatic endometriosis should always be considered as a differential diagnosis in women with recurrent hepatic cysts, regardless of age or previous medical history. In such cases, histology is essential and a pericystectomy should be performed as standard of care. | Georg Fluegen Frank Jankowiak Luisa Zacarias Foehrding Feride Kroepil Wolfram T Knoefel Stefan A Topp | 2013 | World Journal of Gastroenterology2013，19，29： | 9 |
| 5 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 6 | Small intestine bleeding due to multifocal angiosarcoma显示文摘We report a case of an 84-year-old male patient with primary small intestinal angiosarcoma.The patient initially presented with anemia and melena.Consecutive endoscopy revealed no signs of upper or lower active gastrointestinal bleeding.The patient had been diagnosed 3 years previously with an aortic dilation,which was treated with a stent.Computed tomography suggested an aorto-intestinal fistula as the cause of the intestinal bleeding,leading to operative stent explantation and aortic replacement.However,an aorto-intestinal fistula was not found,and the intestinal bleeding did not arrest postoperatively.The constant need for blood transfusions made an exploratory laparotomy imperative,which showed multiple bleeding sites,predominately in the jejunal wall.A distal loop jejunostomy was conducted to contain the small intestinal bleeding and a segmental resection for histological evaluation was performed.The histological analysis revealed a lessdifferentiated tumor with characteristic CD31,cytokeratin,and vimentin expression,which led to the diagnosis of small intestinal angiosarcoma.Consequently,the infiltrated part of the jejunum was successfully resected in a subsequent operation,and adjuvant chemotherapy with paclitaxel was planned.Angiosarcoma of the small intestine is an extremely rare malignant neoplasm that presents with bleeding and high mortality.Early diagnosis and treatment are essential to improve outcome.A small intestinal angiosarcoma is a challenging diagnosis to make because of its rarity,nonspecific symptoms of altered intestinal function,nonspecific abdominal pain,severe melena,and acute abdominal signs.Therefore,a quick clinical and histological diagnosis and decisive measures including surgery and adjuvant chemotherapy should be the aim. | Luisa Zacarias Fhrding Arne Macher Stefan Braunstein Wolfram Trudo Knoefel Stefan Andreas Topp | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 7 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 8 | Complications and treatment of migrated biliary endoprostheses:A review of the literature显示文摘内视镜的胆汁的斯滕特氏印模膏插入是一个生长得很好的过程。它在对待手术后的胆汁的漏缝是特别成功的,并且可以阻止外科的干预。在 3 瞬间以后的 endoprostheses 的一个平淡的变化是一个普通惯例,但是这能被延长到 6 瞬间。我们向书籍的右页 sigmoid 冒号由于胆汁的斯滕特氏印模膏脱臼和移植汇报了一个结肠的穿孔,并且考察了文学。 | Thomas Namdar Andreas Martin Raffel Stefan Andreas Topp Lisa Namdar Ingo Alldinger Marcus Schmitt Wolfram Trudo Knoefel Claus Ferdinand Eisenberger | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 9 | In situ liver transection with portal vein ligation for rapid growth of the future liver remnant in two‐stage liver resection显示文摘 | W. T. Knoefel I. Gabor A. Rehders A. Alexander M. Krausch J. Schulte am Esch G. Fürst S. A. Topp | 2012 | Br J Surg2012，，3： | 2 |
| 10 | Influence of zerobalanced hemofiltration on the course of severe experimental pancreatitis in pigs显示文摘 | Yekebas E F Treede H Knoefel W T | 1999 | Ann Surg1999，229，： | 1 |
| 11 | Portal application of autologous CD133+ bone marrow cells to the liver: a novel concept to support hepatic regeneration显示文摘 | Am Esch JS Knoefel WT Klein M | 2005 | Stem Cells2005，23，4： | 1 |
| 12 | Pancreatic microcir ciculatory changes in experimental panereatitis of graded severity in the rat显示文摘 | Knoefel WT KolliasN Warshaw AL | 1994 | Surg1994，，： | 1 |
| 13 | Pancreatic microcirculatory changes in experimental pancreatitis of graded severity in the rat 显示文摘 | Knoefel TW Kollias N Warshaw AL | | Surgery0，116，： | 1 |
| 14 | Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis:a prospective,randomized trial显示文摘 | Izbicki JR Bloechle C Knoefel WT | 1995 | Ann Surg1995，221，4： | 1 |
| 15 | Drainage versus resection in surpcal therapy of chronic pancreatitis of the bead of the pancreas:a randomized study显示文摘 | Izbicki JR Bloechle C Knoefel WT | 1997 | Chirurg1997，68，4： | 1 |
| 16 | Optimizing surgical therapy for chronic pancreatitis显示文摘 | Knoefel WT Eisenberger CF Strate T | 2002 | Pancreatology2002，2，38： | 1 |
| 17 | Chronic pancreatitis:etiology,pathogenesis,diagnosis and treatment显示文摘 | Strate T Knoefel WT Yekebas E | 2009 | Int Colorectal Dis2009，18，1： | 1 |
| 18 | Quality of life in chronic pancreatitis--results after duodenum-preserving resection of the head of the pancreas显示文摘 | Bloechle C Izbicki JR Knoefel WT | | 0，，01： | 1 |
| 19 | Influence of zero-balanced hemofiltration on the course of severe experimental pancreatitis in pigs显示文摘 | Yekebas EF Treede H Knoefel WT et a1 | 1999 | Ann Surg1999，229，5： | 1 |
| 20 | Prevalence of dementia and probable senile dementia of the Alzheimer type in the Framingham Study显示文摘 | Bachman DL Wolf PA Linn R Knoefel JE Cobb J Belanger A | | 0，，： | 1 |
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