|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sphingosine kinase 1 is upregulated with lysophosphatidic acid receptor 2 in human colorectal cancer显示文摘AIM: To examine the expression of Sph K1, an oncogenic kinase that produces sphingosine 1-phosphate(S1P), and its correlation with the expression of LPAR2, a major lysophosphatidic acid(LPA) receptor overexpressed in various cancers, in human colorectal cancer.METHODS: Real-time reverse-transcription polymerase chain reaction was used to measure the m RNA expression of Sph K1, LPAR2, and the three major S1 P receptors in 27 colorectal cancer samples and corresponding normal tissue samples. We also examined the correlation between the expression of Sph K1 and LPAR2.RESULTS: C o l o r e c t a l c a n c e r t i s s u e i n 2 2 o f 2 7 patients had higher levels of Sph K1 m RNA than in normal tissue. In two-thirds of the samples, Sph K1 m RNA expression was more than two-fold higher than in normal tissue. Consistent with previous reports, LPAR2 m RNA expression in 20 of 27 colorectal cancer tissue samples was higher compared to normal tissue samples. Expression profiles of all three major S1 P receptors, S1PR1, S1PR2, and S1PR3, varied without any trend, with no significant difference in expression between cancer and normal tissues. A highly significant positive correlation was found between Sph K1 and LPAR2 expression [Pearson's correlation coefficient(r) = 0.784 and P < 0.01]. The m RNA levels of Sph K1 and LPAR2 did not correlate with TNM stage.CONCLUSION: Our findings suggest that S1 P andLPA may play important roles in the development ofcolorectal cancer via the upregulation of Sph K1 andLPAR2, both of which could serve as new therapeutictargets in the treatment of colorectal cancer. | Dai Shida Satoru Inoue Yuki Yoshida Atsushi Kodaka Tsutomu Tsuji Makoto Tsuiji | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | 碰撞缓解制动系统在中国交通环境下的性能评估(英文)显示文摘先进驾驶辅助系统,如本田的碰撞缓解制动系统(CMBS),有助于保障交通安全。本文采用自然驾驶数据分析与仿真结合的方法,能更好地评估CMBS在中国交通环境中的性能。首先,由于中国交通环境中安全危急情况的多样性,本文根据过去17年的交通事故统计数据,分析了中国交通事故的特点;其次,筛选出占我国交通事故80%以上的10种交通事故情景,并从北京市交通管理部门收集了353个具有代表性的真实事故案例。所有的真实事故案例都基于事故现场图,通过交通事故重建软件PC-Crash实现了事故场景重建。最终通过搭建PC-Crash和rateEFFECT联合仿真平台并进行了总计176组仿真,对CMBS的避撞有效性进行了系统性的分析和评估。结果显示,其总体避碰效果达到82.4%,说明该系统具有良好的避碰性能,能够提高交通安,改善交通管理。 | 赵志国 郑讯佳 王建强 许庆 KODAKA Kenji | 2019 | Journal of Central South University2019，26，10： | 3 |
| 3 | Etiology and clinical study of community-acquired pneumonia in 157 hospitalized children显示文摘 | Takeshi Tajima Eiichi Nakayama Yasuo Kondo Fumie Hirai Hiroaki Ito Taketoshi Iitsuka Mei Momomura Hirokazu Kutsuma Yuri Kodaka Naomi Funaki Yukishige Yanagawa Kimiko Ubukata | 2006 | Journal of Infection and Chemotherapy2006，，6： | 2 |
| 4 | Selective enrichment with a resuscitation step for isolation of freeze-injured Escherichia coli O157∶H7 from foods显示文摘 | Hara KY Ikedo M Kodaka H | 2000 | Appl Environ Microbiol2000，66，7： | 1 |
| 5 | Propofol concentration re- quirement for laryngeal mask airway insertion was highest with the ProSeal, next highest with the Fastrach, and lowest with the Clas- sic type, with target -controlled infusion 显示文摘 | HANDA TSUTSUI F KODAKA M | 2005 | J Clin Anesth2005，17，5： | 1 |
| 6 | The effects of premedication on induction dose of propofol and hemodynamic responses during induction 显示文摘 | Okamoto Y Kakoi H | 1997 | Musui1997，46，： | 1 |
| 7 | The effects of premeditation on induction doses of propofol and hemodynamic responses during induction显示文摘 | Kodaka M Okamoto Y Kakoi H | 1997 | Masui1997，46，10： | 1 |
| 8 | The influence for gender on loss of consciousness with sevoflurane or propofol显示文摘 | Kodaka M Johansen JW Sebel PS | 2005 | Anesth Analg2005，101，2： | 1 |
| 9 | Practical procedure for demonstrating bacterial flagella显示文摘 | Kodaka H Armfield AY Lombard GL | 1982 | J Clin Microbiol1982，16，5： | 1 |
| 10 | Scanning electron microscopy and electron probe microanalysis studies of human pineal concre- tions 显示文摘 | Kodaka T Mori R Debari K | 1994 | J Electron Microse1994，43，5： | 1 |
| 11 | Synthesis of Hemispherical Poly (2-hydroxylethyl methacrylate-co-methyl methacrylate)/Poly (styreneco-glycidyl methacrylate) Composite Particles with Heterobifunetional Groups by Soap-Free Seeded Emulsion Polymerization显示文摘 | Yong-Zhong Du Takenori Tomohiro Masato Kodaka | 2004 | Macromolecules2004，37，3： | 1 |
| 12 | Superconducting Properties of Neutron Irradiated Nb3Al Muhifilamentary Wires Fabricated by the Nb-tube Process 显示文摘 | Kuroda T Katgiri K Kodaka H | 1996 | Physiea B: Condensed Matter (Amsterdam)1996，216，： | 1 |
| 13 | Gender differences between predicted and measured propofol C (P50) for loss of consciousness 显示文摘 | Kodaka M Suzuki T Maeyama A | 2006 | J Clin Anesth2006，18，7： | 1 |
| 14 | Selective ertdchmentwith a resus-citation step for isolation of freeze-injured Escherichia coli O157:H7 from foods显示文摘 | HARA K Y IKEDO M KODAKA H | 2000 | Appl Environ Microbio2000，66，7： | 1 |
| 15 | Synthesis of hemispherical poly(2-hydroxylethyl-methacrylate-co-methylmethacrylate)/poly (styrene-co-glycidylmethacrylate)with hetero-bifunctional groups on either side by soap free seeded emulsion polmacromolecules显示文摘 | Yong-ZhongDu Takenori Tomohiro Masato Kodaka | 2004 | Macromolecules2004，37，： | 1 |
| 16 | Depressive effects of propofol on apoptotic injury and delayed neuronal death after forebrain ischemia in the rat-comparison with nitrous oxide-oxygen-isoflurane 显示文摘 | Kodaka M Mori T Tanaka K | 2000 | Masui2000，49，2： | 1 |
| 17 | The effect of premedieation on induction doses of propofot and hemodynamic responses during induction显示文摘 | Kodaka M Okamoto Y Kakoi H | 1997 | Masui1997，46，10： | 1 |
| 18 | A transcranial doppler ultrasonography study of cerebrovascular CO2 reactivity in mitochondrial encephalomyopathy显示文摘 | Kodaka R Itagaki Y Matsumoto M | | 0，，： | 1 |
| 19 | Gender differences between predicted and measured propofol C(P50) for loss of consciousness显示文摘 | Kodaka M Suzuki T Maeyama A | 2006 | J Clin Anesth2006，18，7： | 1 |
| 20 | The effects of premedication on induction doses of propofol and hemodynamic responses during induction 显示文摘 | Kodaka M Okamoto Y Kakoi H | 1997 | Masul1997，46，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员