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| 1 | Novel understanding of ABC transporters ABCB1/MDR/P-glycoprotein, ABCC2/MRP2, and ABCG2/BCRP in colorectal pathophysiology显示文摘AIM: To evaluate ATP-binding cassette(ABC) transporters in colonic pathophysiology as they had recently been related to colorectal cancer(CRC) development. METHODS: Literature search was conducted on Pub Med using combinations of the following terms: ABC transporters, ATP binding cassette transporter proteins, inflammatory bowel disease, ulcerative, colitis, Crohns disease, colorectal cancer, colitis, intestinal inflammation, intestinal carcinogenesis, ABCB1/P-glycoprotein(P-gp/CD243/MDR1), ABCC2/multidrug resistance protein 2(MRP2) and ABCG2/breast cancer resistance protein(BCRP), Abcb1/Mdr1 a, abcc2/Mrp2, abcg2/Bcrp, knock-out mice, tight junction, membrane lipid function. RESULTS: Recently, human studies reported thatchanges in the levels of ABC transporters were early events in the adenoma-carcinoma sequence leading to CRC. A link between ABCB1, high fat diet and gut microbes in relation to colitis was suggested by the animal studies. The finding that colitis was preceded by altered gut bacterial composition suggests that deletion of Abcb1 leads to fundamental changes of hostmicrobiota interaction. Also, high fat diet increases the frequency and severity of colitis in specific pathogenfree Abcb1 KO mice. The Abcb1 KO mice might thus serve as a model in which diet/environmental factors and microbes may be controlled and investigated in relation to intestinal inflammation. Potential molecular mechanisms include defective transport of inflammatory mediators and/or phospholipid translocation from one side to the other of the cell membrane lipid bilayer by ABC transporters affecting inflammatory response and/or function of tight junctions, phagocytosis and vesicle trafficking. Also, diet and microbes give rise to molecules which are potential substrates for the ABC transporters and which may additionally affect ABC transporter function through nuclear receptors and transcriptional regulation. Another critical role of ABCB1 was suggested by the finding that ABCB1 expression identifies a subpopulation of pro-inflammatory Th17 cells which were resistant to treatment with glucocorticoids. The evidence for the involvement of ABCC2 and ABCG2 in colonic pathophysiology was weak. CONCLUSION: ABCB1, diet, and gut microbes mutually interact in colonic inflammation, a well-known risk factor for CRC. Further insight may be translated into preventive and treatment strategies. | Vibeke Andersen Katrine Svenningsen Lina Almind Knudsen Axel Kornerup Hansen Uffe Holmskov Allan Stensballe Ulla Vogel | 2015 | World Journal of Gastroenterology2015，21，41： | 10 |
| 2 | Impact of the gut microbiota on rodent models of human disease显示文摘Traditionally bacteria have been considered as either pathogens,commensals or symbionts.The mammal gut harbors 1014 organisms dispersed on approximately1000 different species.Today,diagnostics,in contrast to previous cultivation techniques,allow the identification of close to 100%of bacterial species.This has revealed that a range of animal models within different research areas,such as diabetes,obesity,cancer,allergy,behavior and colitis,are affected by their gut microbiota.Correlation studies may for some diseases show correlation between gut microbiota composition and disease parameters higher than 70%.Some disease phenotypes may be transferred when recolonizing germ free mice.The mechanistic aspects are not clear,but some examples on how gut bacteria stimulate receptors,metabolism,and immune responses are discussed.A more deeper understanding of the impact of microbiota has its origin in the overall composition of the microbiota and in some newly recognized species,such as Akkermansia muciniphila,Segmented filamentous bacteria and Faecalibacterium prausnitzii,which seem to have an impact on more or less severe disease in specific models.Thus,the impact of the microbiota on animal models is of a magnitude that cannot be ignored in future research.Therefore,either models with specific microbiota must be developed,or the microbiota must be characterized in individual studies and incorporated into data evaluation. | Axel Kornerup Hansen Camilla Hartmann Friis Hansen Lukasz Krych Dennis Sandris Nielsen | 2014 | World Journal of Gastroenterology2014，20，47： | 4 |
| 3 | The role of platelets in the pathophysiology of asthma显示文摘 | K. N. Kornerup C. P. Page | 2007 | Platelets2007，，5： | 1 |
| 4 | Quality of reporting masficatory muscle electromyography in 2004 : a systematic review显示文摘 | Armijo-olivo S Gadotti I Kornerup M | 2007 | Journal of Oral Rehabilitation2007，34，5： | 1 |
| 5 | Systolic linear-array multiplier for a class of right-shift algorithms显示文摘 | Kornerup P A | 1994 | IEEE Trans Comput1994，43，8： | 1 |
| 6 | The role of platelets in the pathophyslology of asthma显示文摘 | Kornerup KN Page CP | 2007 | Th Med J2007，100，7： | 1 |
| 7 | An RNS Montgomery modular multiplication algorithm显示文摘 | Bajard J Didier L Kornerup P | 1998 | IEEE Transactions on Computers1998，47，7： | 1 |
| 8 | Reviewing high-radix signed-digit adders显示文摘 | KORNERUP P | 2015 | IEEE Transactions on Computers2015，64，5： | 1 |
| 9 | Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration显示文摘 | Kornerup KN Salmon GP Pitchford SC | 2010 | J Appl Physiol2010，109，3： | 1 |
| 10 | Reviewing 4-to-2 Adders for Multi-operand Addition显示文摘 | Kornerup P | 2005 | Journal of VLSI Signal Processing Systems2005，40，1： | 1 |
| 11 | Digit Selection for SRT Division and Square Root 显示文摘 | KORNERUP P | 2005 | IEEE Transactions on computer2005，54，3： | 1 |
| 12 | Quality of reporting masticatory muscle electromyography in 2004:a systematic review显示文摘 | Armijo-Olivo S Gadotti I Kornerup M | 2007 | Journal of Oral Rehabilitation2007，34，6： | 1 |
| 13 | The role of platelets in the patho- physiology of asthma 显示文摘 | Kornerup KN Page CP | 2007 | Platelets2007，18，： | 1 |
| 14 | The role of platelets in thepathophysiology of asthma 显示文摘 | Kornerup KN Page CP | 2007 | Platelets2007，18，5： | 1 |
| 15 | An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis显示文摘 | Sinéad M. Ryan Jason McMorrow Anita Umerska Hetal B. Patel Kristin N. Kornerup Lidia Tajber Evelyn P. Murphy Mauro Perretti Owen I. Corrigan David J. Brayden | 2013 | Journal of Controlled Release2013，，2： | 1 |
| 16 | The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis 显示文摘 | Patel HB Kornerup KN Sampaio AL | 2012 | Ann Rheum Dis2012，71，11： | 1 |
| 17 | Transvascular low-density lipoprotein transport in patients with diabetes mellitus(type 2):a noninvasive in vivo isotope technique显示文摘 | Kornerup K Nordestgaard BG Feldt-Raussen B | 2002 | Arterioscler Thromb Vasc Bio12002，22，7： | 1 |
| 18 | 谷蛋白对NOD小鼠糖尿病的发生及其肠道菌群影响的研究显示文摘 | 凌凤俊 Axel Kornerup Hansen 林德贵 | 2006 | 中国兽医杂志2006，42，5： | 0 |
| 19 | Initial joint bleed volume in a delayed on-demand treatment setup correlates with subsequent synovial changes in hemophilic mice显示文摘Background: Hemophilic arthropathy is a debilitating morbidity of hemophilia caused by recurrent joint bleeds. We investigated if the joint bleed volume, before initiation of treatment, was linked to the subsequent degree of histopathological changes and the development of bone pathology in a mouse model of hemophilic arthropathy.Methods: FVIII knock-out(F8-KO) mice were dosed with a micro-CT blood pool agent prior to induction of hemarthrosis. Eight hours after induction, the bleed volume was quantified with micro computed tomography(micro-CT) and recombinant FVIII treatment initiated. On Day 8, inflammation in the knees was characterized by fluorescence molecular tomography. On Day 14, knee pathology was characterized by micro-CT and histopathology. In a second study, contrast agent was injected into the knee of wild-type(WT) mice, followed by histopathological evaluation on Day 14.Results: The average joint bleed volume before treatment was 3.9 mm3. The inflammation-related fluorescent intensities in the injured knees were significantly increased on Day 8. The injured knees had significantly increased synovitis scores, vessel counts, and areas of hemosiderin compared to un-injured knees. However, no cartilage-or bone pathology was observed. The bleed volume before initiation of treatment correlated with the degree of synovitis and was associated with high fluorescent intensity on Day 8. In F8-KO and WT mice, persistence of contrast agent in the joint elicited morphological changes.Conclusion: When applying a delayed on-demand treatment regimen to hemophilic mice subjected to an induced knee hemarthrosis, the degree of histopathological changes on Day 14 reflected the bleed volume prior to initiation of treatment. | Kare Kryger Vols Mads Kjelgaard-Hansen Carsten Dan Ley Axel Kornerup Hansen Maj Petersen | 2020 | Animal Models and Experimental Medicine2020，3，2： | 0 |
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