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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | Switching possibilities of reverse switched-on dynistors and principles of RSD circuitry(review)显示文摘 | Korotkov S V | 2002 | Instruments and Experimental Techniques2002，45，4： | 1 |
| 3 | Quantum nondemolition squeezing of a nanomechanical resonator 显示文摘 | RUSKOV R SCHWAB K KOROTKOV A N | 2005 | IEEE Transactions on Nanotechnology2005，41，1： | 1 |
| 4 | Small-Signal Modeling of Soft-Switched Asymmetrical Half-Bridge DC/DC Converter显示文摘 | Sergey Korotkov Valery Meleshin Alexey Nemchinov Simon Fraidlin | 1995 | IEEE Transaction on Power Electronics1995，，： | 1 |
| 5 | Structural and functional studies of Eps C,a crucial component of the type 2 secretion system from Vibrio cholerae显示文摘 | Korotkov K V Krumm B Bagdasarian M | 2006 | J Mol Biol2006，363，2： | 1 |
| 6 | Distribution and functional consequences of nucleotide polymorphism in the 3′ -untranslated region of the human Sep15 gene显示文摘 | Korotkov KV Mehta R | 2001 | Cancer Res2001，61，5： | 1 |
| 7 | Experimental violation of a Bell’s inequality in time with weak measurement显示文摘 | Palacios-laloy Agustin Mallet Fran?ois Nguyen Fran?ois Bertet Patrice Vion Denis Esteve Daniel Korotkov Alexander N | 2010 | Nature Physics2010，，6： | 1 |
| 8 | Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells显示文摘 | Kumaraswamy E Zhou Y | 2001 | J Biol Chem2001，276，15： | 1 |
| 9 | Acapacitor cell of a capacitive energy storage with a switchbased on reverse switch-on dynistors显示文摘 | Fridman B E Korotkov S V Martynenko V A | 2008 | Instruments and Experimental Techniques2008，51，6： | 1 |
| 10 | Switching possibilities of reverse switched-on dynistors and principles of RSD circuitry: review显示文摘 | Korotkov S V | 2002 | Instru ments and Experimental Techniques2002，45，4： | 1 |
| 11 | Drop-Spark Discharge:an Atomization and Excitation Source for Atomic Emission Sensors显示文摘 | Yagov V V Korotkov A S Zuev B K | 1998 | Mendeleev Communications1998，4，： | 1 |
| 12 | Crystal structure of the N - terminal domain of EccA1 ATPase from the ESX - 1 secretion system of Mycobacterium tuberculosis 显示文摘 | Wagner JM Evans TJ Korotkov KV | 2014 | Proteins2014，82，1： | 1 |
| 13 | Carbon in vegetation of Russian forests: Methods to estimate storage and geographical distribution显示文摘 | V. Alexeyev R. Birdsey V. Stakanov I. Korotkov | | 0，1995，： | 1 |
| 14 | Quantum nondemolition squeezing of a nanomeehanieal resonator显示文摘 | RUSKOV R SCHWAB K KOROTKOV A N | 2005 | IEEE Transactions on Nanotechnology2005，4，1： | 1 |
| 15 | High-voltage RSD switches of submegaampere current pulses of microsecond duration显示文摘 | Grekhov I V Kozlov A K Korotkov S V | 2003 | Instruments and Experimental Techniques2003，46，14： | 1 |
| 16 | Possible performance of capacitively coupled single-electron transistors in digi-tal circuits显示文摘 | KOROTKOV A N CHEN R H LIKHAREV K K | 1995 | J Apple Phys1995，78，： | 1 |
| 17 | Deep aeceptnrs in undoped GaN显示文摘 | Reshchikov M A Shahedipour F Korotkov R Y | 1999 | Physica B1999，，： | 1 |
| 18 | Theoretical analysis of the resistively coupled single-electron transistor显示文摘 | KOROTKOV A N | 1998 | Applied Physics Letters1998，72，24： | 1 |
| 19 | A high-voltage reverse switch-on dynistor switch with a transistor control circuit显示文摘 | Grekhov I V Kozlov A K Korotkov S V | 2002 | Instruments and Experimental Techniques2002，45，5： | 1 |
| 20 | Preferred orientations in polycrystalline SnO2 films grown by atmospheric pressure chemical vapor deposition显示文摘 | Korotkov R Y Ricou P Farran A J E | 2006 | Thin Solid Films2006，502，12： | 1 |
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