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| 1 | Probiotic Lactobacillus rhamnosus downregulates FCER1 and HRH4 expression in human mast cells显示文摘AIM:To investigate the effects of four probiotic bacteria and their combination on human mast cell gene expression using microarray analysis.METHODS:Human peripheral-blood-derived mast cells were stimulated with Lactobacillus rhamnosus (L.rhamnosus) GG (LGG),L.rhamnosus Lc705 (Lc705),Propionibacterium freudenreichii ssp.shermanii JS (PJS) and Bifidobacterium animalis ssp.lactis Bb12 (Bb12) and their combination for 3 or 24 h,and were subjected to global microarray analysis using an Affymetrix GeneChip Human Genome U133 Plus 2.0 Array.The gene expression differences between unstimulated and bacteria-stimulated samples were further analyzed with GOrilla Gene Enrichment Analysis and Visualization Tool and MeV Multiexperiment Viewer-tool.RESULTS:LGG and Lc705 were observed to suppress genes that encoded allergy-related high-affinity IgE receptor subunits α and γ (FCER1A and FCER1G,respectively) and histamine H4 receptor.LGG,Lc705 and the combination of four probiotics had the strongest effect on the expression of genes involved in mast cell immune system regulation,and on several genes that encoded proteins with a pro-inflammatory impact,such as interleukin (IL)-8 and tumour necrosis factor alpha.Also genes that encoded proteins with anti-inflammatory functions,such as IL-10,were upregulated.CONCLUSION:Certain probiotic bacteria might diminish mast cell allergy-related activation by downregulation of the expression of high-affinity IgE and histamine receptor genes,and by inducing a pro-inflammatory response. | Anna Oksaharju Matti Kankainen Riina A Kekkonen Ken A Lindstedtt Petri T Kovanen Riitta Korpela Minja Miettinen | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 2 | Apolipoprotein composition and particle size affect HDL degradation by chymase:effect on cellular cholesterol efflux显示文摘 | Lee M Kovanen PT Tedeschi G | 2003 | J Lipid Res2003，44，： | 1 |
| 3 | Role of complement activation in atherosclerosis显示文摘 | Oksjoki R Kovanen PT Pentikainen MO | 2003 | Curr Opin Lipidol2003，14，5： | 1 |
| 4 | Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation 显示文摘 | Oksjoki R Jarva H Kovanen PT | 2003 | Arterioscler Thromb Vasc Biol2003，23，4： | 1 |
| 5 | TNF-α and IL-10 selectively induce expression of 92-kDa gelatinase by human macrophages显示文摘 | Saren P Welgus HG Kovanen PT | 1996 | J Immunol1996，157，： | 1 |
| 6 | Mast cells and degradation of pericellular and extracellular matrices: potential contributions to erosion, rupture and intraplaque haemorrhage of atherosclerotic plaques 显示文摘 | Kovanen PT | 2007 | Biochem Soc Trans2007，35，5： | 1 |
| 7 | Volumetric changes of articular cartilage during stress relaxation in unconfined compression 显示文摘 | WONG M PONTICIELLO M KOVANEN V | 2000 | Journal of biomechanics2000，33，9： | 1 |
| 8 | Mast ceils and degradation of pericellu larand extracellu larm atrices:potential contributions to erosion,rupture and intraplaque haemorrhage of a therosc leroticplaques显示文摘 | Kovanen PT | 2007 | B iochem Soc Trans2007，35，5： | 1 |
| 9 | Increased binding of LDL to liver membranes from rats treated with 17a-ethinylestradiol显示文摘 | Brown MS Goldstein JL | 1979 | J Biol Chem1979，254，11： | 1 |
| 10 | Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction显示文摘 | Kovanen PT Kaartinen M Paavonen T | 1995 | Circulation1995，92，5： | 1 |
| 11 | Increased circulating concentrations and augmented myocardial extraction of osteoprotegerin in heart failure due to left ventricular pressure overload显示文摘 | Helske S Kovanen PT Lindstedt KA | 2007 | Eur J Heart Fail2007，9，5： | 1 |
| 12 | JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling 显示文摘 | Sporri B Kovanen PE Sasaki A | 2001 | Blood2001，97，1： | 1 |
| 13 | A role for cardiac mast cells in the pathogenesis of hypertensive heart disease 显示文摘 | Shiota N Rysa J Kovanen PT | 2003 | J Hypertens2003，21，10： | 1 |
| 14 | Myeloperoxidase and hypochlorite,but not copper ions,oxidize heparin-bound LDL particles and release them from heparin 显示文摘 | PENTIKAINEN M O OORNI K KOVANEN P T | 2001 | Arterioscler Thromb Vasc Biol2001，21，12： | 1 |
| 15 | Mast cells:multipotent local effector cells in athero-thrombosis显示文摘 | Kovanen PT | | 0，，： | 1 |
| 16 | Mast cells: muhipotent local effector cells in athero- thrombosis显示文摘 | Kovanen PT | 2007 | Immunol Rev2007，217，： | 1 |
| 17 | TNF-αand IL-β se- lectively induce expression of 92-kD agelatinase by human macrophages 显示文摘 | Saren P Welgus HG Kovanen PT | 1996 | Immunol1996，157，9： | 1 |
| 18 | Aggregati bacter actinomyeetemcomitans induces MMP-9 expression and proatherogenic lipoprotein profile in apoE-deficient mice显示文摘 | Tuomainen AM Jauhiainen M Kovanen PT et aI | 2008 | Mi erob Pathog2008，44，2： | 1 |
| 19 | TNF-alpha and IL-1 beta selectively induce expression of 92-kDa gelatinase by human macrophages 显示文摘 | Saren P Welgus H G Kovanen P T | 1996 | J Immunol1996，157，9： | 1 |
| 20 | Relation of PvuⅡsite polymorphism in the COL1A2 gene to the risk of fractures in prepubertal Finnish girls显示文摘 | Suuriniemi M Mahonen A Kovanen V | 2003 | Physiol Genomics2003，14，7： | 1 |
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