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| 1 | Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights显示文摘AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157,L-NAME,L-arginine(alone/combined),saline] was bath at the blood deprived colon segment. During reperfusion,medication was BPC 157 or saline. We recorded(USB microscope camera) vessel presentation through next 15 min of ischemic colitis(ICrats) or reperfusion(removed ligations)(IC + RL-rats);oxidative stress as MDA(increased(IC-and IC + RLrats)) and NO levels(decreased(IC-rats);increased(IC + RL-rats)) in colon tissue. IC + OB-rats [IC-rats had additional colon obstruction(OB)] for 3 d(IC + OBrats),then received BPC 157 bath. RESULTS Commonly,in colon segment(25 mm,2 ligations on left colic artery and vein,3 arcade vessels within ligated segment),in IC-,IC + RL-,IC + OB-rats,BPC 157(10 μg/kg) bath(1 m L/rat) increased vessel presentation,inside/outside arcade interconnections quickly reappeared,mucosal folds were preserved and the pale areas were small and markedly reduced. BPC 157 counteracted worsening effects induced by L-NAME(5 mg) and L-arginine(100 mg). MDA-and NO-levels were normal in BPC 157 treated IC-rats and IC + RLrats. In addition,on day 10,BPC 157-treated IC + OBrats presented almost completely spared mucosa with very small pale areas and no gross mucosal defects;the treated colon segment was of normal diameter,and only small adhesions were present.CONCLUSION BPC 157 is a fundamental treatment that quickly restores blood supply to the ischemically injured area and rapidly activates collaterals. This effect involves the NO system. | Antonija Duzel Josipa Vlainic Marko Antunovic Dominik Malekinusic Borna Vrdoljak Mariam Samara Slaven Gojkovic Ivan Krezic Tinka Vidovic Zdenko Bilic Mario Knezevic Marko Sever Nermin Lojo Antonio Kokot Marijan Kolovrat Domagoj Drmic Jaksa Vukojevic Tamara Kralj Katarina Kasnik Marko Siroglavic Sven Seiwerth Predrag Sikiric | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 2 | Determination of the Composition of Calcite-vaterite Mixtures by Infrared Spectrophotometry 显示文摘 | Andersen F A Kralj D | 1991 | Applied Spectroscopy1991，45，10： | 1 |
| 3 | Absorption and elimination of imatinib through the rat intestine in vitro 显示文摘 | Kralj E Zakelj S Trontelj J | 2014 | Int J Pharma- eeut2014，460，12： | 1 |
| 4 | Novel cyano-and amidino-substituted derivatives of styryl-2-benzimidazoles and benzimidazo quinolines,synthesis,photochemical synthesis,DNA binding,and antitumor evaluation显示文摘 | Hranjec M Kralj M Piantanida I | 2007 | J Med Chem2007，50，： | 1 |
| 5 | Producing Ultra-thin Silica Coatings on Iron-oxide Nanoparticles to Improve Their Surface Reactivity显示文摘 | Kralj S Makovec D Campelj S | 2010 | The Journal of Magnetism and Magnetic Materials2010，322，： | 1 |
| 6 | Numerical investigation of fixed orthodontic brackets 显示文摘 | Middleton J Hubsch P Kralj B | 2000 | Proc Instn Mech Engrs2000，214，3： | 1 |
| 7 | Analysis of standingup and sitting down in humans:de? nitions and normative da-ta presentation 显示文摘 | KRALJ A JAEGER R J MUNIH M | 1990 | J Biomech1990，23，1： | 1 |
| 8 | Novel cyano-and amidinobenzothiazole derivatives:synthesis,antitumor evaluation,and X-ray and quantitative structure activity relationship(QSAR)analysis显示文摘 | CALETA I KRALJ M MARJANOVIC M | 2009 | J Med Chem2009，52，6： | 1 |
| 9 | Needlestick injuries in heahhcare - frequency, causes, and preventive strategies 显示文摘 | Hofmann F Kralj N Beie M | 2002 | Gesundheitswesen2002，64，5： | 1 |
| 10 | Improved standard FPA method-resolving problems with upper boundaries in the rating complexity proeess显示文摘 | Kralj T Rozman I Hericko M | 2005 | Journal of Systems and Software2005，77，： | 1 |
| 11 | The influence of some naturally occurring minerals on the precipitation of calcium car- bonate polymorphs 显示文摘 | Kralj D Vdovi N | 2000 | Water Research2000，34，1： | 1 |
| 12 | Metals in particle-size fractions of the soils of five European cities 显示文摘 | MARSAN A F BIASIOLI M KRALJ T | 2008 | Environmental Pollution2008，152，： | 1 |
| 13 | Growth,structure and properties of ultra-thin copper films on a V(110)surface显示文摘 | Pervan P Milun M | 1999 | Surf Sci1999，423，： | 1 |
| 14 | Conservative treatment of female stress urinary incontinence with functional electrical stimulation 显示文摘 | Bozo Kralj | 1999 | European J Obstet Gynecol1999，85，： | 1 |
| 15 | Metals in particle-size fractions of the soils of five European cities显示文摘 | Ajmone-Marsan F Biasioli M Kralj T | 2008 | Environmental pollution2008，152，： | 1 |
| 16 | 查看详情显示文摘 | Maloj(c)i(c) G Piantanida I Marini(c) M (Z)ini(c) M Marjanovi(c) M Kralj M Paveli(c) K Schneider H | | 0，，： | 1 |
| 17 | Effect of Divalent Cations on the Formation and Structure of Calcium Carbonate Polymorphs显示文摘 | BreeviL Nthig-Laslo V Kralj D | 1996 | Journal of the Chemical Society Faraday Transactions1996，92，6： | 1 |
| 18 | Effect of the nonsteroidal anti inflammatory drug indomethacin on proliferation and apoptosis of colon carcinoma cells 显示文摘 | Kapitanovic S Kovacevic D | 2001 | J Cancer Res Clin Oncol2001，127，3： | 1 |
| 19 | Multiresidue method for determination of 90 pesticides in freshfruits and vegetables using solid-phase extraction and gas chromatography-mass spectrometry显示文摘 | Darinka stajnbaher Lucija Zupancic Kralj | 2003 | Journal of Chromatography A2003，1015，： | 1 |
| 20 | Electrokinetic properties of spontaneously precipitated calcium carbonate polymorphs:the influence of organic substances显示文摘 | Neda Vdovic Damir Kralj | 2000 | Colloids and Surfaces A:physicochemical and Engineering Aspects2000，，161： | 1 |
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