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| 1 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Phase I/II study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma 显示文摘 | Kruit WH van Ojik HH Brichard VG | 2005 | Int J Cancer2005，117，4： | 1 |
| 3 | Migraine as a risk factor for subclinical brain lesions显示文摘 | Kruit MC van Buchem MA Hofman PAM | | 0，，： | 1 |
| 4 | Increased fecal neutral sterol loss upon liver X receptor activation is independent ofbiliary sterol secretion in mice显示文摘 | Kruit JK Plosch T Havinga R | 2005 | Gastroenterology2005，128，1： | 1 |
| 5 | Migraine as a risk factor for subclinical brain lesions显示文摘 | Kruit M C van Buchem M A Hofman P A | 2004 | JAMA2004，291，： | 1 |
| 6 | Reduction of cholesterol absorption by dietary plant sterols and stanols in mice is independent of the Abcg5/8 transporter显示文摘 | Plosch T Kruit JK Bloks VW Huijkman NC Havinga R Duchateau GS Lin Y Kuipers F | | 0，，08： | 1 |
| 7 | A practical protocol for dynamic modelling of activated sludge systems 显示文摘 | Hulsbeek J J W Kruit J Roeleveld P J | 2002 | Water Sci Tech2002，45，6： | 1 |
| 8 | Intestinal ABCA 1 is a significant contributor to plasma HDL-C and apo-B levels in vivo显示文摘 | BRUNHAM L KRUIT JK PAPE TD | 2006 | J Clin Invest2006，116，4： | 1 |
| 9 | The impact of a migraine attack and its after-effects on perceptual organization,attention,and working memory显示文摘 | Koppen H Palm-Meinders I Kruit M | 2011 | Cephalalgia2011，31，14： | 1 |
| 10 | Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice显示文摘 | Kruit J K Plosch T Havinga R | 2005 | Gastroenterology2005，128，1： | 1 |
| 11 | Migraine is associated with an increased risk of deep white matter lesions,subclinical pos-terior circulation infarcts and brain iron accumulation:the popula-tion-based MRI CAMERA study显示文摘 | Kruit MC van Buchem MA Launer LJ | | 0，，： | 1 |
| 12 | Phase 1 study of subcutaneously administered recombinant human interleukin-12 in patients with advanced renal cell cancer 显示文摘 | Portielje JE Kruit WH Schuler M | 1999 | Clin Cancer Res1999，5，12： | 1 |
| 13 | Electron spectra from multiphoton ionization of xenon at 1064, 532, and 355nm 显示文摘 | Kruit P Kimman J Muller H G | 1983 | Phys RevA1983，28，1： | 1 |
| 14 | Beta-cell ABCA1 influences insulin secretion,glucose homeostasis and response to thiazolidinedione treatment显示文摘 | Brunham L R Kruit J K Pape T D | 2007 | Nat Med2007，13，3： | 1 |
| 15 | Repeated administrations of interleukin (IL) -12 are associated with persistently elevated plasma levels of IL-10 and declining IFN-gamma, tumor necrosis factor-alpha, IL- 6, and IL-8 responses显示文摘 | Portielje JE Lamers CH Kruit WH | 2003 | Clin Cancer Res2003，9，1： | 1 |
| 16 | Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice显示文摘 | Kruit JK Ploseh T Havinga R | 2005 | Gastroenterology2005，128，1： | 1 |
| 17 | Reduced cholesterol absorption upon PPARdelta activation coincides with decreasedintestinal expression of NPC 1 L1 显示文摘 | van der Veen JN Kruit JK Havinga R | 2005 | J Lipid Res2005，46，3： | 1 |
| 18 | Reduced cholesterol absorption upon PPARdelta activation coincides with decreased in- testinal expression of NPCILI显示文摘 | van der Veen J N Kruit J K Havinga R | 2005 | J Lipid Res2005，46，3： | 1 |
| 19 | Migraine as a riskfactor for subclinical brain lesion 显示文摘 | Kruit MC van Buchen MA Hofman PA | 2004 | JAMA2004，291，4： | 1 |
| 20 | Cholesterol in islet dysfunction and type 2 diabetes显示文摘 | Brunham LR Kruit JK Verchere CB | | 0，，02： | 1 |
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