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| 1 | One hundred and one over-the-scope-clip applications forsevere gastrointestinal bleeding,leaks and fistulas显示文摘AIM: To investigate the efficacy and clinical outcome of patients treated with an over-the-scope-clip(OTSC) system for severe gastrointestinal hemorrhage, perforations and fistulas.METHODS: From 02-2009 to 10-2012, 84 patients were treated with 101 OTSC clips. 41 patients(48.8%) presented with severe upper-gastrointestinal(GI) bleeding, 3(3.6%) patients with lower-GI bleeding, 7 patients(8.3%) underwent perforation closure, 18 patients(21.4%) had prevention of secondary perforation, 12 patients(14.3%) had control of secondary bleeding after endoscopic mucosal resection or endoscopic submucosal dissection(ESD) and 3 patients(3.6%) had an intervention on a chronic fistula. RESULTS: In 78/84 patients(92.8%), primary treatment with the OTSC was technically successful. Clinical primary success was achieved in 75/84 patients(89.28%). The overall mortality in the study patients was 11/84(13.1%) and was seen in patients with life threatning upper GI hemorrhage. There was no mortality in any other treatment group. In detail OTSC application lead to a clinical success in 35/41(85.36%) patients with upper GI bleeding and in 3/3 patients with lower GI bleeding. Technical success of perforation closure was 100% while clinical success was seen in 4/7 cases(57.14%) due to attendant circumstances unrelated to the OTSC. Technical and clinic success was achieved in 18/18(100%) patients for the prevention of bleeding or perforation after endoscopic mucosal resection and ESD and in 3/3 cases of fistula closure. Two application-related complications were seen(2%).CONCLUSION: This largest single center experience published so far confirms the value of the OTSC for GI emergencies and complications. Further clinical experience will help to identify optimal indications for its targeted and prophylactic use. | Edris Wedi Susana Gonzalez Detlev Menke Elena Kruse Kai Matthes Juergen Hochberger | 2016 | World Journal of Gastroenterology2016，22，5： | 28 |
| 2 | Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases显示文摘AIM: To evaluate and compare the expression profiles of CXCL12 (SDF-1), CCL19 (MIP-3β), CCL20 (MIP-3α) and CCL21 (6Ckine, Exodus2) and their receptors on RNA and protein levels in hepatocellular carcinoma (HCC) versus colorectal liver metastases (CRLM) and to elucidate their impact on the carcinogenesis and progression of malignant liver diseases. METHODS: Chemokine expression was analyzed by RT-PCR and ELISA in 11 cases of HCC specimens and in 23 cases of CRLM and corresponding adjacent non- tumorous liver tissues, respectively. Expressions of their receptors CXCR4, CCR6 and CCR7 were analyzed by RT- PCR and Western blot analysis in the same cases of HCC and CRLM. RESULTS: Significant up-regulation for CCL20/CCR6 was detected in both cancer types. Moreover, CCL20 demonstrated significant overexpression in CRLM in relation to the HCC tissues. Being significantly up- regulated only in CRLM, CXCR4 displayed an aberrant expression pattern with respect to the HCC tissues. CONCLUSION: Correlation of CXCR4 expression with CRLM suggests CXCR4 as a potential predictive factor for CRLM. High level expression of CCL20 and its receptor CCR6 in HCC and CRLM with marked up- regulation of CCL20 in CRLM in relation to HCC tissues indicates involvement of the CCL20/CCR6 ligand-receptor pair in the carcinogenesis and progression of hepatic malignancies. | Claudia Rubie Vilma Oliveira Frick Mathias Wagner Christina Weber Bianca Kruse Katja Kempf Jochen Knig Bettina Rau Martin Schilling | 2006 | World Journal of Gastroenterology2006，12，41： | 24 |
| 3 | 白细胞介素-1受体拮抗剂阿那白滞素用于危重症患儿继发性噬血细胞综合缈脓毒症/多器官功能障碍/巨噬细胞活化综合征治疗研究显示文摘目的 继发性噬血细胞综合征、巨噬细胞活化综合征以及脓毒症炎症表现相同,常可导致多器官功能障碍综合征而需重症监护治疗。本文主要阐述应用重组白细胞介素-1受体拮抗剂,即阿那白滞素(Kineret)减少全身炎症反应的相关经验。 | Rajasekaran S Kruse K Kovey K 方伯梁(译) 钱素云(校) | 2014 | 中国小儿急救医学2014，21，6： | 9 |
| 4 | 管线直接铺设技术显示文摘管线直接铺设技术借助“管道推进器”(Pipe Thruster)的连续推进,单向连续地将预制管线铺设到位。如同顶管法一样,土体挖掘作业仍通过与管线相连的微型隧道掘进机来完成,开挖面通过泥浆维持,通常用膨润土泥浆。由于新方法的成功,已在几个工程中得以应用。管道推进器所产生的推力是直接铺管工程设计时考虑的一个重要M题。本文利用ABAQUS软件包里的有限元法分析了将管线推入钻孔时所需要的力及相关因素。对有限元法计算结果的分析表明这几种因素之间具有强烈的相互影响。而且,根据这些因素和管段受力分析得出了推力计算公式,并将最近几个工程中测量出的推进力与根据这些计算公式的计算值进行了对比。结果袁明,摩擦系数E和￡应分别取为100Pa和0.3,推力设计值应将计算出的推力值乘以1.5倍的安全系数。这个安全系数主要是考虑到在停顿期会有2.5%的概率超过上述计算值后提出的。 | Pruiksma J. D. Pfeff D. Nugroho R.P. Boeije H.M.G. Kruse 张健 万谦 | 2013 | 非开挖技术2013，，2： | 6 |
| 5 | General review of magnetic resonance elastography显示文摘Magnetic resonance elastography(MRE) is an innovative imaging technique for the non-invasive quantification of the biomechanical properties of soft tissues via the direct visualization of propagating shear waves in vivo using a modified phase-contrast magnetic resonance imaging(MRI) sequence. Fundamentally,MRE employs the same physical property that physicians utilize when performing manual palpation- that healthy and diseased tissues can be differentiated on the basis of widely differing mechanical stiffness. By performing 'virtual palpation ',MRE is able to provide information that is beyond the capabilities of conventional morphologic imaging modalities. In an era of increasing adoption of multi-parametric imaging approaches for solving complex problems,MRE can be seamlessly incorporated into a standard MRI examination to provide a rapid,reliable and comprehensive imaging evaluation at a single patient appointment. Originally described by the Mayo Clinic in 1995,the technique represents the most accurate non-invasive method for the detection and staging of liver fibrosis and is currently performed in more than 100 centers worldwide. In this general review,the mechanical properties of soft tissues,principles of MRE,clinical applications of MRE in the liver and beyond,and limitations and future directions of this discipline-are discussed. Selected diagrams and images are provided for illustration. | Gavin Low Scott A Kruse David J Lomas | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 6 | Bone marrow-derived pancreatic stellate cells in rats显示文摘胰腺的星形的房间(PSC ) 在前,在期间并且在胰腺的损害以后的起源和命运是争论的一件事。在胰腺的纤维变性的致病的 PSC 的关键角色通常被接受。然而,房间的周转仍然保持阴暗。现在的学习处理了潜在的骨头髓(BM ) 的问题 PSC 的起源。我们由 grafting 使用了稳定的造血的 chimerism 的一个模型在领受人老鼠的照耀以后表示 BM 房间的提高的绿荧光蛋白质(eGFP ) 。Chimerism 被 eGFP 积极的房间的 FACS 分析在外部血检测。Dibutyltin 二氯化物(DBTC ) 被用来超过 4 个星期与随后的恢复导致尖锐胰腺的发炎。调查集中于孤立的房间检测休息 PSC 人口。从妄想的老鼠的胰获得的 eGFP 积极的 PSC 的发生在健康胰腺的织物是约 7% 并且 4 个星期在导致 DBTC 的尖锐发炎以后在恢复的胰显著地增加了到 18% 的一个平均数。我们的结果建议导出 BM 的祖先房间在胰代表可更新的星形的房间的来源。在新生以后放松 PSC 的增加的数字在导致发炎的激活以后向导出 BM 的房间的提高的招募指向一个静止状态的胰或重新获得。 | Gisela Sparmann Marie-Luise Kruse Nicole Hofmeister-Mielke Dirk Koczan Robert Jaster Stefan Liebe Daniel Wolff Joerg Emmrich | 2010 | Cell Research2010，20，3： | 4 |
| 7 | Cobalt–copper based catalysts for higher terminal alcohols synthesis via Fischer–Tropsch reaction显示文摘The production of higher terminal alcohols through CO hydrogenation according to the Fischer–Tropsch(F–T) process has been a topic of interest since the Institut Fran?ais du Pétrole(IFP) demonstrated shortchain C_1–C_6mixed alcohols production over cobalt–copper based catalysts. A number of catalyst formulations were screened for their suitability at that time. In particular, the addition of Cr, Zn, Al, Mn and V to Co Cu was investigated. In a number of patents, it was shown that catalyst preparation is crucial in these catalyst formulations and that high alcohols selectivity can only be achieved by carefully respecting the procedures and recipes. This short critical review highlights recent developments in Co Cu-based catalysts for higher terminal alcohols synthesis via F–T synthesis. Special attention will be given to catalyst preparation which according to developments in our group is based on oxalate precipitation. This way we show that the close association of Co and Cu on the one hand and promoter/dispersant on the other are of utmost importance to ensure high performance of the catalysts. We shall concentrate on 'Co Cu Mn','Co Cu Mo' and 'Co Cu Nb' catalyst formulations, all prepared via oxalate precipitation and combined with'entrainment techniques' if necessary, and show high total alcohols selectivity can be obtained with tunable Anderson-Schulz-Flory chain-lengthening probability. Either long-chain C_8–C_(14)terminal alcohols as feedstock for plasticizers, lubricants and detergents, or short-chain C_2–C_5alcohols as 'alkanol' fuels or fuel additives can be formed this way. | Yizhi Xiang Norbert Kruse | 2016 | Journal of Energy Chemistry2016，25，6： | 4 |
| 8 | Effect of process parameters on additive-free electrospinning of regenerated silk fibroin nonwovens显示文摘Silk fibroin is a biomaterial with multiple beneficial properties for use in regenerative medicine and tissue engineering.When dissolving and processing the reconstituted silk fibroin solution by electrospinning,the arrangement and size of fibers can be manifold varied and according fiber diameters reduced to the nanometer range.Such nonwovens show high porosity as well as potential biocompatibility.Usually,electrospinning of most biomaterials demands for the application of additives,which enable stable electrospinning by adjusting viscosity,and are intended to evaporate during processing or to be washed out afterwards.However,the use of such additives increases costs and has to be taken into account in terms of biological risks when used for biomedical applications.In this study,we explored the possibilities of additive-free electrospinning of pure fibroin nonwovens and tried to optimize process parameters to enable stable processing.We used natural silk derived from the mulberry silkworm Bombyx mori.After degumming,the silk fibroin was dissolved and the viscosity of the spinning solution was controlled by partial evaporation of the initial solving agent.This way,we were able to completely avoid the use of additives and manufacture nonwovens,which potentially offer higher biocompatibility and reduced immunogenicity.Temperature and relative humidity during electrospinning were systematically varied(25–35°C,25–30%RH).In a second step,the nonwovens optionally underwent methanol treatment to initiate beta-sheet formation in order to increase structural integrity and strength.Comprehensive surface analysis on the different nonwovens was performed using scanning electron microscopy and supplemented by additional mechanical testing.Cytotoxicity was evaluated using BrdU-assay,XTT-assay,LDH-assay and live-dead staining.Our findings were,that an increase of temperature and relative humidity led to unequal fiber diameters and defective nonwovens.Resistance to penetration decreased accordingly.The most uniform fiber diameters of 998±63 nm were obtained at 30°C and 25%relative humidity,also showing the highest value for resistance to penetration(0.20 N).The according pure fibroin nonwoven also showed no signs of cytotoxicity.However,while the biological response showed statistical evidence,the material characteristics showed no statistically significant correlation to changes of the ambient conditions within the investigated ranges.We suggest that further experiments should explore additional ranges for temperature and humidity and further focus on the repeatability of material properties in dependency of suitable process windows. | Alexander Kopp Ralf Smeets Martin Gosau Nadja Kröger Sandra Fuest Marius Köpf Magnus Kruse Judith Krieger Rico Rutkowski Anders Henningsen Simon Burg | 2020 | Bioactive Materials2020，5，2： | 3 |
| 9 | 通过设计确保安全和隐私:保障无人机的未来显示文摘2015年10月,在交通委员会的倡议下,欧盟议员通过了一项决议,即《无人机:商业及娱乐用途与安全性规则指引》。该决议旨在对无人飞行器(UAV)或“无人机”进行规范,确保它们不会对公共安全或个人隐私造成威胁。 | Eva Schulz-Kamm Jacques Kruse Brandao | 2016 | 中国集成电路2016，0，6： | 2 |
| 10 | Bevacizumab (Avastin) eye drops inhibit corneal neovascularization显示文摘 | Felix Bock Yanyan K?nig Friedrich Kruse Martin Baier Claus Cursiefen | 2008 | Graefe’s Archive for Clinical and Experimental Ophthalmology2008，，2： | 2 |
| 11 | PDCA-Zyklus und Morbidit?ts- und Mortalit?tskonferenz als Basis der Wundinfektionsreduktion in der Kolorektalchirurgie?显示文摘 | P. Vogel G. Vassilev B. Kruse Y. Cankaja | 2010 | Zentralbl Chir2010，，04： | 2 |
| 12 | Serum tumor markers and PET/CT imaging for tumor recurrence detection显示文摘 | Vibeke Kruse Veronique Cocquyt Marleen Borms Alex Maes Christophe Wiele | 2013 | Annals of Nuclear Medicine2013，，2： | 2 |
| 13 | Dynamic simulation and experimental validation of a two-phase closed thermosyphon for geothermal application显示文摘The heat transfer perfonmance of a vertical two-phase closed thermosyphon(TPCT)used in a geothermal heat pump was experimentally investigated.The TPCT is a verticalplain steel pipe with inner diameter of 114 mm and bored 368 m deep underground.Carbon dioxide(CO_(2))is used as working fluid.In the TPCT there is no condensation section.CO_(2)is condensed by the evaporator pf the heat pump,flows into the head of the TPCT and nuns down as a falling film along the inner wall of the pipe.For the heat transfer simulation in the TPCT,a quasi-dynamic model in which the mass transfer between the liquid and vapor phases as well as the conduction heat transfer from the surrounding soil towards the pipe is treated dynamically.However the film flow modeling is based on the Nusselt theory of frilm condenssation.The compauison of the experimental data with the numerical simulation is presented and discussed. | Johann-Christoph Ebeling Xing Luo Stephan Kabelac Sebastian Luckmann Horst Kruse | 2017 | Propulsion and Power Research2017，6，2： | 2 |
| 14 | Irritable bowel syndrome and chronic pelvic pain: A singular or two different clinical syndrome?显示文摘Irritable bowel syndrome (IBS) and chronic pelvic pain (CPP) are both somatoform disorders with a high prevalence within the population in general. The objective was to compare both entities, to fi nd the differences and the similarities related to epidemiology and psychosocial aspects like stressful life events, physical and sexual abuse, illness behaviour and comorbidity. The technical literature was reviewed systematically from 1971 to 2006 and compared. According to literature, IBS and CPP seem to be one rather than two different entities with the same localisation of pain. Both syndromes also are similar concerning prevalence, the coexistence of mental and somatoform disorders, the common history of sexual and physical abuse in the past and their health care utilization. It could be shown that there were many similarities between IBS and CPP. Nevertheless both are traded as different clinical pictures as far. Therefore it seems to be reasonable and necessary to generate a common diagnosis algorithm and to bring gynaecologists and gastroenterologists into dialogue. | Anna Matheis Ute Martens Johannes Kruse Paul Enck | 2007 | World Journal of Gastroenterology2007，13，25： | 2 |
| 15 | Putting teachers at the center of reform:Learning schools and professional communities显示文摘 | Louis Karen Seashore Kruse Sharon Ray-id Mary Anne | 1996 | NASSP BuUetin (National Association of Secondary School Principals)1996，9，： | 1 |
| 16 | A polymorphic mink ( Mustela vison ) dinucleotide repeat显示文摘 | Brusgaard Malchenko Christensen Kruse | 1998 | Animal - Genetics ( United Kingdom)1998，29，6： | 1 |
| 17 | Comparison of Airborne Hyperspeetral Data and EO-1 Hyperion for Mineral Mapping显示文摘 | Boardman J W Huntington J F | 2003 | IEEE Transactions on Geoseience and Remote Sensing2003，41，6： | 1 |
| 18 | Ki-67 immunoquantitation in cervical intraepithelial neoplasia(CIN):a sensitive marker for grading显示文摘 | Kruse A J Baak J P De Bruin P C | 2001 | J Pathol2001，193，1： | 1 |
| 19 | Capture efficiency and size selectivity of two types of pots for pred king crabs in the Bering Sea显示文摘 | Zhou S J Kruse G H | 2000 | Alaska Fishery Research Bulletin2000，6，2： | 1 |
| 20 | Quality control of Kryptofix or tetrabutyammonium ion in FDG sample by quantitative HPLC analysis proceeding of 47th annual meeting 显示文摘 | Kruse MA Rees SE Watkins GL | 2000 | Nucl Med2000，27，2： | 1 |
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